YIL046W / MET30

F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL046W / MET30

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:7.13|P-value:4.81E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:5.41|P-value:3.14E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:6.15|P-value:3.86E-10 ID:SGTC_108|Compound:0509-0257|FD-Score:3.37|P-value:3.70E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.25|P-value:5.81E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.14|P-value:8.41E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.89|P-value:5.02E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:10.80|P-value:1.70E-27 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.15|P-value:8.12E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.76|P-value:4.18E-9 ID:SGTC_299|Compound:1273-0059|FD-Score:4.78|P-value:8.61E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:8.64|P-value:2.71E-18 ID:SGTC_341|Compound:1486-1430|FD-Score:3.44|P-value:2.87E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-4.87|P-value:5.54E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:-4.02|P-value:2.94E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.11|P-value:1.95E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.37|P-value:3.72E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:7.91|P-value:1.25E-15 ID:SGTC_435|Compound:c-PAF|FD-Score:7.99|P-value:6.54E-16 ID:SGTC_455|Compound:paf C-16|FD-Score:3.18|P-value:7.32E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.89|P-value:3.04E-19 ID:SGTC_514|Compound:4466-0038|FD-Score:3.79|P-value:7.56E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:3.48|P-value:2.45E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.24|P-value:5.91E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.20|P-value:6.74E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:5.31|P-value:5.50E-8 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.59|P-value:1.62E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.24|P-value:5.91E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.88|P-value:5.19E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.57|P-value:1.76E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.73|P-value:9.52E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-9.41|P-value:2.43E-21 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.75|P-value:8.86E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.20|P-value:6.75E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.20|P-value:6.80E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.24|P-value:6.01E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-4.14|P-value:1.69E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.93|P-value:4.16E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.13|P-value:8.73E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.95|P-value:1.30E-9 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.22|P-value:6.46E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.10|P-value:9.50E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.02|P-value:2.61E-7 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.09|P-value:2.11E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.29|P-value:4.95E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.39|P-value:3.45E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.41|P-value:3.19E-8 ID:SGTC_1732|Compound:st034308|FD-Score:-3.84|P-value:6.01E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.16|P-value:7.80E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.16|P-value:7.82E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.86|P-value:5.96E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-9.95|P-value:1.25E-23 ID:SGTC_2057|Compound:5236571|FD-Score:-4.36|P-value:6.37E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.64|P-value:1.70E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-4.54|P-value:2.81E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-5.82|P-value:2.93E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:-6.45|P-value:5.47E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.81|P-value:6.84E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.81|P-value:6.87E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.76|P-value:8.44E-5 ID:SGTC_2299|Compound:7976368|FD-Score:4.86|P-value:5.81E-7 ID:SGTC_2321|Compound:7390090|FD-Score:-3.39|P-value:3.44E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.72|P-value:1.00E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.40|P-value:5.36E-6 ID:SGTC_2348|Compound:9022543|FD-Score:4.42|P-value:4.92E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.97|P-value:3.64E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.25|P-value:5.70E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.18|P-value:7.37E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.17|P-value:7.70E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.28|P-value:5.08E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.42|P-value:3.14E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-4.43|P-value:4.78E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.61|P-value:9.90E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:3.91|P-value:4.58E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.60|P-value:2.27E-26 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.83|P-value:6.87E-7 ID:SGTC_3285|Compound:9112818|FD-Score:-3.53|P-value:2.05E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:7.13|P-value:4.81E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:5.41|P-value:3.14E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:6.15|P-value:3.86E-10 ID:SGTC_108|Compound:0509-0257|FD-Score:3.37|P-value:3.70E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.25|P-value:5.81E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.14|P-value:8.41E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.89|P-value:5.02E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:10.80|P-value:1.70E-27 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.15|P-value:8.12E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.76|P-value:4.18E-9 ID:SGTC_299|Compound:1273-0059|FD-Score:4.78|P-value:8.61E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:8.64|P-value:2.71E-18 ID:SGTC_341|Compound:1486-1430|FD-Score:3.44|P-value:2.87E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-4.87|P-value:5.54E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:-4.02|P-value:2.94E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.11|P-value:1.95E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.37|P-value:3.72E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:7.91|P-value:1.25E-15 ID:SGTC_435|Compound:c-PAF|FD-Score:7.99|P-value:6.54E-16 ID:SGTC_455|Compound:paf C-16|FD-Score:3.18|P-value:7.32E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.89|P-value:3.04E-19 ID:SGTC_514|Compound:4466-0038|FD-Score:3.79|P-value:7.56E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:3.48|P-value:2.45E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.24|P-value:5.91E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.20|P-value:6.74E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:5.31|P-value:5.50E-8 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.59|P-value:1.62E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.24|P-value:5.91E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.88|P-value:5.19E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.57|P-value:1.76E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.73|P-value:9.52E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-9.41|P-value:2.43E-21 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.75|P-value:8.86E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.20|P-value:6.75E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.20|P-value:6.80E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.24|P-value:6.01E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-4.14|P-value:1.69E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.93|P-value:4.16E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.13|P-value:8.73E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.95|P-value:1.30E-9 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.22|P-value:6.46E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.10|P-value:9.50E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.02|P-value:2.61E-7 ID:SGTC_1578|Compound:josamycin|FD-Score:-4.09|P-value:2.11E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.29|P-value:4.95E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.39|P-value:3.45E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.41|P-value:3.19E-8 ID:SGTC_1732|Compound:st034308|FD-Score:-3.84|P-value:6.01E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.16|P-value:7.80E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.16|P-value:7.82E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.86|P-value:5.96E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-9.95|P-value:1.25E-23 ID:SGTC_2057|Compound:5236571|FD-Score:-4.36|P-value:6.37E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.64|P-value:1.70E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-4.54|P-value:2.81E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-5.82|P-value:2.93E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:-6.45|P-value:5.47E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.81|P-value:6.84E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.81|P-value:6.87E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.76|P-value:8.44E-5 ID:SGTC_2299|Compound:7976368|FD-Score:4.86|P-value:5.81E-7 ID:SGTC_2321|Compound:7390090|FD-Score:-3.39|P-value:3.44E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.72|P-value:1.00E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.40|P-value:5.36E-6 ID:SGTC_2348|Compound:9022543|FD-Score:4.42|P-value:4.92E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.97|P-value:3.64E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.25|P-value:5.70E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.18|P-value:7.37E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.17|P-value:7.70E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.28|P-value:5.08E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.42|P-value:3.14E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-4.43|P-value:4.78E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.61|P-value:9.90E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:3.91|P-value:4.58E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.60|P-value:2.27E-26 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.83|P-value:6.87E-7 ID:SGTC_3285|Compound:9112818|FD-Score:-3.53|P-value:2.05E-4

Top fitness defect scores for YIL046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 10.80 7.5 µM 1.70E-27 14 1.75E-27 0.72
2 SGTC_2651 1327-0036 10.60 5.0 µM 2.27E-26 15 2.33E-26 0.56
3 SGTC_513 4245-1575 8.89 41.7 µM 3.04E-19 unfolded protein response 2 3.10E-19 0.35
4 SGTC_309 k408-0051 8.64 1.5 µM 2.71E-18 3 2.76E-18 0.78
5 SGTC_435 c-PAF 7.99 6.7 µM 6.54E-16 4 6.65E-16 1.37
6 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 7.91 8.0 µM 1.25E-15 3 1.28E-15 0.86
7 SGTC_20 0481-0013 7.13 4.9 µM 4.81E-13 1 4.87E-13 1.21
8 SGTC_81 0411-0046 6.15 10.0 µM 3.86E-10 19 3.90E-10 0.32
9 SGTC_1469 k284-2957 5.95 126.0 µM 1.30E-9 4 1.31E-9 0.46
10 SGTC_266 formosanin C 5.76 406.0 nM 4.18E-9 sphingolipid biosynthesis & PDR1 8 4.21E-9 0.02
11 SGTC_2582 agaric acid 5.61 100.0 µM 9.90E-9 redox potentiating 17 9.97E-9 0.13
12 SGTC_58 0957-0393 5.41 9.0 µM 3.14E-8 cell wall 33 3.17E-8 0.01
13 SGTC_1725 st036284 5.41 20.6 µM 3.19E-8 3 3.21E-8 0.91
14 SGTC_730 1436-0052 5.31 41.2 µM 5.50E-8 mitochondrial processes 10 5.53E-8 0.15
15 SGTC_1568 digitonin 5.02 820.0 nM 2.61E-7 sphingolipid biosynthesis & PDR1 8 2.63E-7 0.22
16 SGTC_2299 7976368 4.86 114.9 µM 5.81E-7 3 5.84E-7 0.13
17 SGTC_1982 st072467 4.86 71.9 µM 5.96E-7 3 5.99E-7 0.11
18 SGTC_2688 kanamycin b 4.83 96.7 µM 6.87E-7 calcium & mitochondrial duress 6 6.91E-7 0.07
19 SGTC_299 1273-0059 4.78 1.4 µM 8.61E-7 5 8.66E-7 0.17
20 SGTC_2115 tiliquinol 4.64 12.8 µM 1.70E-6 1 1.70E-6 0.60

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.396 3.32E-126 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.388 5.40E-121 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.369 1.38E-108 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.363 4.86E-105 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.361 5.79E-104 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.329 3.11E-85 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.325 3.32E-83 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.296 1.29E-68 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.267 8.45E-56 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.264 1.15E-54 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.236 1.12E-43 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.220 6.57E-38 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.217 5.01E-37 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.205 3.11E-33 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.189 2.27E-28 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis