YIL052C / RPL34B

Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL052C / RPL34B

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:6.50|P-value:2.19E-8 ID:SGTC_8|Compound:0354-0001|FD-Score:9.63|P-value:2.75E-16 ID:SGTC_18|Compound:0111-0177|FD-Score:12.90|P-value:6.60E-28 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.83|P-value:2.63E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.63|P-value:5.15E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:9.36|P-value:1.75E-15 ID:SGTC_59|Compound:0330-0160|FD-Score:7.35|P-value:3.05E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:10.20|P-value:4.72E-18 ID:SGTC_103|Compound:0844-0104|FD-Score:7.63|P-value:6.67E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:6.92|P-value:2.90E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:8.93|P-value:2.96E-14 ID:SGTC_201|Compound:4262-0159|FD-Score:7.86|P-value:1.88E-11 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.67|P-value:9.79E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.20|P-value:2.00E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.57|P-value:9.47E-11 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.13|P-value:8.39E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.95|P-value:1.32E-11 ID:SGTC_312|Compound:4092-0653|FD-Score:10.20|P-value:5.73E-18 ID:SGTC_320|Compound:4092-0846|FD-Score:6.78|P-value:5.86E-9 ID:SGTC_393|Compound:acivicin|FD-Score:-5.54|P-value:1.71E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.26|P-value:5.24E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.46|P-value:8.45E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:6.02|P-value:2.00E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:9.92|P-value:3.54E-17 ID:SGTC_528|Compound:3492-0019|FD-Score:8.01|P-value:8.14E-12 ID:SGTC_564|Compound:3555-0129|FD-Score:3.70|P-value:9.11E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:10.10|P-value:8.08E-18 ID:SGTC_690|Compound:glyoxal|FD-Score:8.71|P-value:1.16E-13 ID:SGTC_710|Compound:3448-4187|FD-Score:7.27|P-value:4.81E-10 ID:SGTC_852|Compound:0418-0143|FD-Score:4.50|P-value:7.39E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.67|P-value:9.76E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.52|P-value:1.70E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:4.40|P-value:1.03E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.29|P-value:6.04E-8 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.43|P-value:3.10E-8 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.15|P-value:2.38E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.36|P-value:3.22E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.89|P-value:3.34E-9 ID:SGTC_1226|Compound:3909-7979|FD-Score:9.96|P-value:2.70E-17 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.99|P-value:3.83E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:13.70|P-value:8.17E-31 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.94|P-value:4.50E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.25|P-value:1.73E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-4.09|P-value:3.02E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.30|P-value:1.45E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.12|P-value:2.61E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.15|P-value:2.37E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.24|P-value:7.54E-8 ID:SGTC_1646|Compound:st011709|FD-Score:3.87|P-value:5.59E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.67|P-value:9.84E-9 ID:SGTC_1750|Compound:st081859|FD-Score:13.40|P-value:6.33E-30 ID:SGTC_1752|Compound:st044819|FD-Score:6.14|P-value:1.18E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.20|P-value:2.19E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.47|P-value:2.30E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:5.43E-25 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.85|P-value:5.95E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.27|P-value:1.68E-12 ID:SGTC_1895|Compound:st058434|FD-Score:3.80|P-value:6.82E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-4.34|P-value:1.40E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.69|P-value:9.24E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.85|P-value:5.83E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.95|P-value:1.51E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.20|P-value:1.99E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.80|P-value:2.63E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.98|P-value:4.01E-4 ID:SGTC_2221|Compound:6807166|FD-Score:4.09|P-value:2.81E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.86|P-value:5.72E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:21.20|P-value:1.25E-71 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.88|P-value:5.39E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.95|P-value:1.65E-5 ID:SGTC_2267|Compound:7931562|FD-Score:-3.71|P-value:9.39E-4 ID:SGTC_2278|Compound:7948257|FD-Score:6.10|P-value:1.42E-7 ID:SGTC_2300|Compound:7976697|FD-Score:-3.70|P-value:9.66E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.52|P-value:1.67E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.07|P-value:5.76E-12 ID:SGTC_2430|Compound:5571206|FD-Score:6.92|P-value:2.92E-9 ID:SGTC_2495|Compound:cafestol|FD-Score:4.85|P-value:2.18E-5 ID:SGTC_2505|Compound:galangin|FD-Score:6.11|P-value:1.33E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.96|P-value:4.50E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.23|P-value:1.97E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.00|P-value:3.80E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.32|P-value:1.35E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.03|P-value:1.13E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.66|P-value:4.29E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:7.60|P-value:7.84E-11 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.19|P-value:2.04E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:15.00|P-value:1.24E-36 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.13|P-value:3.98E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.10|P-value:8.02E-18 ID:SGTC_2690|Compound:usnic acid|FD-Score:-5.01|P-value:1.35E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.28|P-value:1.69E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.56|P-value:1.43E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.88|P-value:5.39E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.95|P-value:4.31E-4 ID:SGTC_2912|Compound:7964298|FD-Score:8.87|P-value:4.36E-14 ID:SGTC_2976|Compound:9009005|FD-Score:5.19|P-value:6.18E-6 ID:SGTC_3027|Compound:9089541|FD-Score:4.96|P-value:1.46E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-5.91|P-value:3.61E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.13|P-value:7.66E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.78|P-value:7.22E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.72|P-value:9.24E-4 ID:SGTC_3107|Compound:9121808|FD-Score:5.21|P-value:5.65E-6 ID:SGTC_3114|Compound:9122766|FD-Score:4.42|P-value:9.84E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.25|P-value:1.87E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.67|P-value:9.87E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.01|P-value:1.80E-9 ID:SGTC_3321|Compound:9137793|FD-Score:6.41|P-value:3.46E-8 ID:SGTC_7|Compound:0192-1582|FD-Score:6.50|P-value:2.19E-8 ID:SGTC_8|Compound:0354-0001|FD-Score:9.63|P-value:2.75E-16 ID:SGTC_18|Compound:0111-0177|FD-Score:12.90|P-value:6.60E-28 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.83|P-value:2.63E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.63|P-value:5.15E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:9.36|P-value:1.75E-15 ID:SGTC_59|Compound:0330-0160|FD-Score:7.35|P-value:3.05E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:10.20|P-value:4.72E-18 ID:SGTC_103|Compound:0844-0104|FD-Score:7.63|P-value:6.67E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:6.92|P-value:2.90E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:8.93|P-value:2.96E-14 ID:SGTC_201|Compound:4262-0159|FD-Score:7.86|P-value:1.88E-11 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.67|P-value:9.79E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.20|P-value:2.00E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:7.57|P-value:9.47E-11 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.13|P-value:8.39E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.95|P-value:1.32E-11 ID:SGTC_312|Compound:4092-0653|FD-Score:10.20|P-value:5.73E-18 ID:SGTC_320|Compound:4092-0846|FD-Score:6.78|P-value:5.86E-9 ID:SGTC_393|Compound:acivicin|FD-Score:-5.54|P-value:1.71E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.26|P-value:5.24E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.46|P-value:8.45E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:6.02|P-value:2.00E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:9.92|P-value:3.54E-17 ID:SGTC_528|Compound:3492-0019|FD-Score:8.01|P-value:8.14E-12 ID:SGTC_564|Compound:3555-0129|FD-Score:3.70|P-value:9.11E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:10.10|P-value:8.08E-18 ID:SGTC_690|Compound:glyoxal|FD-Score:8.71|P-value:1.16E-13 ID:SGTC_710|Compound:3448-4187|FD-Score:7.27|P-value:4.81E-10 ID:SGTC_852|Compound:0418-0143|FD-Score:4.50|P-value:7.39E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.67|P-value:9.76E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.52|P-value:1.70E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:4.40|P-value:1.03E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.29|P-value:6.04E-8 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.43|P-value:3.10E-8 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.15|P-value:2.38E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.36|P-value:3.22E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.89|P-value:3.34E-9 ID:SGTC_1226|Compound:3909-7979|FD-Score:9.96|P-value:2.70E-17 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.99|P-value:3.83E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:13.70|P-value:8.17E-31 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.94|P-value:4.50E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.25|P-value:1.73E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-4.09|P-value:3.02E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.30|P-value:1.45E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.12|P-value:2.61E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.15|P-value:2.37E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.24|P-value:7.54E-8 ID:SGTC_1646|Compound:st011709|FD-Score:3.87|P-value:5.59E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.67|P-value:9.84E-9 ID:SGTC_1750|Compound:st081859|FD-Score:13.40|P-value:6.33E-30 ID:SGTC_1752|Compound:st044819|FD-Score:6.14|P-value:1.18E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.20|P-value:2.19E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.47|P-value:2.30E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:5.43E-25 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.85|P-value:5.95E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.27|P-value:1.68E-12 ID:SGTC_1895|Compound:st058434|FD-Score:3.80|P-value:6.82E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-4.34|P-value:1.40E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.69|P-value:9.24E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.85|P-value:5.83E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.95|P-value:1.51E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.20|P-value:1.99E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.80|P-value:2.63E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.98|P-value:4.01E-4 ID:SGTC_2221|Compound:6807166|FD-Score:4.09|P-value:2.81E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.86|P-value:5.72E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:21.20|P-value:1.25E-71 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.88|P-value:5.39E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.95|P-value:1.65E-5 ID:SGTC_2267|Compound:7931562|FD-Score:-3.71|P-value:9.39E-4 ID:SGTC_2278|Compound:7948257|FD-Score:6.10|P-value:1.42E-7 ID:SGTC_2300|Compound:7976697|FD-Score:-3.70|P-value:9.66E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.52|P-value:1.67E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.07|P-value:5.76E-12 ID:SGTC_2430|Compound:5571206|FD-Score:6.92|P-value:2.92E-9 ID:SGTC_2495|Compound:cafestol|FD-Score:4.85|P-value:2.18E-5 ID:SGTC_2505|Compound:galangin|FD-Score:6.11|P-value:1.33E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.96|P-value:4.50E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.23|P-value:1.97E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.00|P-value:3.80E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.32|P-value:1.35E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.03|P-value:1.13E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.66|P-value:4.29E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:7.60|P-value:7.84E-11 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.19|P-value:2.04E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:15.00|P-value:1.24E-36 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.13|P-value:3.98E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.10|P-value:8.02E-18 ID:SGTC_2690|Compound:usnic acid|FD-Score:-5.01|P-value:1.35E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.28|P-value:1.69E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.56|P-value:1.43E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.88|P-value:5.39E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.95|P-value:4.31E-4 ID:SGTC_2912|Compound:7964298|FD-Score:8.87|P-value:4.36E-14 ID:SGTC_2976|Compound:9009005|FD-Score:5.19|P-value:6.18E-6 ID:SGTC_3027|Compound:9089541|FD-Score:4.96|P-value:1.46E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-5.91|P-value:3.61E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.13|P-value:7.66E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.78|P-value:7.22E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.72|P-value:9.24E-4 ID:SGTC_3107|Compound:9121808|FD-Score:5.21|P-value:5.65E-6 ID:SGTC_3114|Compound:9122766|FD-Score:4.42|P-value:9.84E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.25|P-value:1.87E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.67|P-value:9.87E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.01|P-value:1.80E-9 ID:SGTC_3321|Compound:9137793|FD-Score:6.41|P-value:3.46E-8

Top fitness defect scores for YIL052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2233 sulbentine 21.20 40.4 µM 1.25E-71 2 1.86E-100
2 SGTC_2651 1327-0036 15.00 5.0 µM 1.24E-36 6 5.73E-51
3 SGTC_1304 1165-0502 13.70 251.0 µM 8.17E-31 2 9.54E-43
4 SGTC_1750 st081859 13.40 2.4 µM 6.33E-30 endomembrane recycling 27 1.72E-41
5 SGTC_18 0111-0177 12.90 500.0 nM 6.60E-28 3 1.22E-38
6 SGTC_1844 rapamycin 12.20 4.0 nM 5.43E-25 23 1.59E-34
7 SGTC_87 0100-0052 10.20 35.5 µM 4.72E-18 5 9.80E-25
8 SGTC_312 4092-0653 10.20 6.8 µM 5.73E-18 ergosterol depletion effects on membrane 12 1.29E-24
9 SGTC_2688 kanamycin b 10.10 96.7 µM 8.02E-18 calcium & mitochondrial duress 24 2.07E-24
10 SGTC_568 1193-0097 10.10 7.5 µM 8.08E-18 ERAD & cell cycle 24 2.09E-24
11 SGTC_1226 3909-7979 9.96 35.4 µM 2.70E-17 6 1.15E-23
12 SGTC_514 4466-0038 9.92 2.6 nM 3.54E-17 cell wall 22 1.67E-23
13 SGTC_8 0354-0001 9.63 70.0 µM 2.75E-16 4 3.02E-22
14 SGTC_46 0329-0187a 9.36 2.2 µM 1.75E-15 9 4.09E-21
15 SGTC_163 1327-0036 8.93 7.5 µM 2.96E-14 16 2.19E-19
16 SGTC_2912 7964298 8.87 10.9 µM 4.36E-14 cell wall 21 3.78E-19
17 SGTC_690 glyoxal 8.71 20.3 µM 1.16E-13 22 1.51E-18
18 SGTC_1877 wortmannin 8.27 25.0 µM 1.68E-12 22 6.43E-17
19 SGTC_2679 rapamycin 8.13 1.0 nM 3.98E-12 41 2.18E-16
20 SGTC_2408 sulbentine 8.07 18.4 µM 5.76E-12 12 3.66E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.452 6.87E-169 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.420 1.31E-143 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.372 1.00E-110 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.355 1.50E-100 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.353 3.40E-99 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.345 2.27E-94 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.290 4.43E-66 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.273 1.42E-58 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.267 4.56E-56 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.264 1.05E-54 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.264 1.06E-54 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.261 1.81E-53 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.254 2.12E-50 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.253 5.18E-50 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.248 3.89E-48 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies