YIL057C / RGI2

Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL057C / RGI2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.40|P-value:9.01E-13 ID:SGTC_60|Compound:0986-0278|FD-Score:3.92|P-value:1.00E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.47|P-value:1.09E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:-4.37|P-value:1.35E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.79|P-value:2.59E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.79|P-value:2.70E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:5.35|P-value:1.77E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.89|P-value:1.12E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.07|P-value:5.50E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.77|P-value:1.76E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.71|P-value:2.17E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.42|P-value:1.37E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.56|P-value:3.16E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.47|P-value:4.95E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.10|P-value:4.93E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.96|P-value:8.65E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.08|P-value:5.37E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.25|P-value:8.73E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.32|P-value:8.11E-4 ID:SGTC_2040|Compound:5100729|FD-Score:7.43|P-value:7.30E-13 ID:SGTC_2165|Compound:5727197|FD-Score:-3.44|P-value:4.73E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.26|P-value:9.97E-4 ID:SGTC_2308|Compound:7584454|FD-Score:6.11|P-value:3.15E-9 ID:SGTC_2557|Compound:derrustone|FD-Score:4.13|P-value:4.41E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:1.22E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.37|P-value:5.99E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.79|P-value:1.85E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.93|P-value:2.21E-14 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.97|P-value:6.76E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.50|P-value:4.49E-4 ID:SGTC_2968|Compound:9090663|FD-Score:6.75|P-value:6.76E-11 ID:SGTC_3047|Compound:9092122|FD-Score:4.32|P-value:1.99E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.75|P-value:1.85E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.40|P-value:6.34E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.38|P-value:5.78E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.40|P-value:9.01E-13 ID:SGTC_60|Compound:0986-0278|FD-Score:3.92|P-value:1.00E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.47|P-value:1.09E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:-4.37|P-value:1.35E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.79|P-value:2.59E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:4.79|P-value:2.70E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:5.35|P-value:1.77E-7 ID:SGTC_753|Compound:1322-0200|FD-Score:3.89|P-value:1.12E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.07|P-value:5.50E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.77|P-value:1.76E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.71|P-value:2.17E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.42|P-value:1.37E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.56|P-value:3.16E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.47|P-value:4.95E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.10|P-value:4.93E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.96|P-value:8.65E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.08|P-value:5.37E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.25|P-value:8.73E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.32|P-value:8.11E-4 ID:SGTC_2040|Compound:5100729|FD-Score:7.43|P-value:7.30E-13 ID:SGTC_2165|Compound:5727197|FD-Score:-3.44|P-value:4.73E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.26|P-value:9.97E-4 ID:SGTC_2308|Compound:7584454|FD-Score:6.11|P-value:3.15E-9 ID:SGTC_2557|Compound:derrustone|FD-Score:4.13|P-value:4.41E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:1.22E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.37|P-value:5.99E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.79|P-value:1.85E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.93|P-value:2.21E-14 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.97|P-value:6.76E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.50|P-value:4.49E-4 ID:SGTC_2968|Compound:9090663|FD-Score:6.75|P-value:6.76E-11 ID:SGTC_3047|Compound:9092122|FD-Score:4.32|P-value:1.99E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.75|P-value:1.85E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.40|P-value:6.34E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.38|P-value:5.78E-4

Top fitness defect scores for YIL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 7.93 96.7 µM 2.21E-14 calcium & mitochondrial duress 67 1.13E-15
2 SGTC_2040 5100729 7.43 123.0 µM 7.30E-13 6 5.25E-14
3 SGTC_58 0957-0393 7.40 9.0 µM 9.01E-13 cell wall 147 6.62E-14
4 SGTC_2968 9090663 6.75 33.4 µM 6.76E-11 4 7.58E-12
5 SGTC_2308 7584454 6.11 197.6 µM 3.15E-9 3 5.13E-10
6 SGTC_2651 1327-0036 5.79 5.0 µM 1.85E-8 80 3.59E-9
7 SGTC_704 1310-0270 5.35 142.0 µM 1.77E-7 10 4.28E-8
8 SGTC_454 lyso-paf C-16 4.79 6.7 µM 2.59E-6 6 8.15E-7
9 SGTC_514 4466-0038 4.79 2.6 nM 2.70E-6 cell wall 116 8.52E-7
10 SGTC_378 3970-0959 4.47 8.3 µM 1.09E-5 11 3.93E-6
11 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.42 90.6 µM 1.37E-5 20 5.05E-6
12 SGTC_3047 9092122 4.32 49.5 µM 1.99E-5 13 7.63E-6
13 SGTC_2557 derrustone 4.13 83.8 µM 4.41E-5 27 1.83E-5
14 SGTC_1932 st074806 4.10 40.9 µM 4.93E-5 22 2.06E-5
15 SGTC_1941 st076221 4.08 61.8 µM 5.37E-5 sphingolipid biosynthesis & PDR1 74 2.27E-5
16 SGTC_825 1988-2224 4.07 89.6 µM 5.50E-5 cell wall signaling 31 2.33E-5
17 SGTC_1935 st074532 3.96 41.6 µM 8.65E-5 31 3.82E-5
18 SGTC_60 0986-0278 3.92 202.0 µM 1.00E-4 16 4.50E-5
19 SGTC_753 1322-0200 3.89 289.0 µM 1.12E-4 24 5.10E-5
20 SGTC_2582 agaric acid 3.86 100.0 µM 1.22E-4 redox potentiating 325 5.55E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 7.91E-103 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.281 5.24E-62 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.234 6.42E-43 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.233 1.43E-42 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.231 1.08E-41 YIL124W AYR1 hom NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
0.219 1.03E-37 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.205 3.30E-33 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.200 1.03E-31 YKL053W_d YKL053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
0.190 1.04E-28 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.190 9.89E-29 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.187 6.52E-28 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.185 3.41E-27 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.180 1.01E-25 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.179 1.53E-25 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.172 9.42E-24 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes