YIL058W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL058W / YIL058W

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-4.41|P-value:8.73E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.21|P-value:8.85E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-5.69|P-value:1.48E-8 ID:SGTC_319|Compound:1348-1596|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.19|P-value:9.07E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.45|P-value:3.95E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.61|P-value:2.12E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.24|P-value:7.82E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.22|P-value:8.42E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.86|P-value:8.07E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.54|P-value:2.72E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.90|P-value:8.82E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.20|P-value:8.98E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.46|P-value:3.61E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-6.34|P-value:3.16E-10 ID:SGTC_1730|Compound:st033808|FD-Score:-3.62|P-value:2.10E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.21|P-value:8.66E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.22|P-value:8.42E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.83|P-value:9.08E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.17|P-value:9.87E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.18|P-value:9.51E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.07|P-value:3.68E-5 ID:SGTC_2333|Compound:9017922|FD-Score:8.03|P-value:2.32E-15 ID:SGTC_2334|Compound:9017922|FD-Score:4.06|P-value:3.74E-5 ID:SGTC_2338|Compound:7999974|FD-Score:6.79|P-value:1.67E-11 ID:SGTC_2339|Compound:9000433|FD-Score:-3.84|P-value:9.12E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.22|P-value:8.45E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.15|P-value:2.54E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.32|P-value:5.99E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.55|P-value:4.76E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.36|P-value:5.32E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.34|P-value:1.16E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.41|P-value:4.41E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.28|P-value:6.83E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.18|P-value:9.82E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.52|P-value:3.00E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.96|P-value:5.56E-5 ID:SGTC_3313|Compound:9133968|FD-Score:7.47|P-value:1.54E-13 ID:SGTC_3335|Compound:9143315|FD-Score:3.91|P-value:6.70E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.41|P-value:8.73E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.21|P-value:8.85E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-5.69|P-value:1.48E-8 ID:SGTC_319|Compound:1348-1596|FD-Score:3.63|P-value:1.97E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.19|P-value:9.07E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.45|P-value:3.95E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.61|P-value:2.12E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.24|P-value:7.82E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.22|P-value:8.42E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.86|P-value:8.07E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.54|P-value:2.72E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.90|P-value:8.82E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.20|P-value:8.98E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.46|P-value:3.61E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-6.34|P-value:3.16E-10 ID:SGTC_1730|Compound:st033808|FD-Score:-3.62|P-value:2.10E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.21|P-value:8.66E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.22|P-value:8.42E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.83|P-value:9.08E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.17|P-value:9.87E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.18|P-value:9.51E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.07|P-value:3.68E-5 ID:SGTC_2333|Compound:9017922|FD-Score:8.03|P-value:2.32E-15 ID:SGTC_2334|Compound:9017922|FD-Score:4.06|P-value:3.74E-5 ID:SGTC_2338|Compound:7999974|FD-Score:6.79|P-value:1.67E-11 ID:SGTC_2339|Compound:9000433|FD-Score:-3.84|P-value:9.12E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.22|P-value:8.45E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.15|P-value:2.54E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.32|P-value:5.99E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.55|P-value:4.76E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.36|P-value:5.32E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.34|P-value:1.16E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.41|P-value:4.41E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.28|P-value:6.83E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.18|P-value:9.82E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.52|P-value:3.00E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.96|P-value:5.56E-5 ID:SGTC_3313|Compound:9133968|FD-Score:7.47|P-value:1.54E-13 ID:SGTC_3335|Compound:9143315|FD-Score:3.91|P-value:6.70E-5

Top fitness defect scores for YIL058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2333 9017922 8.03 200.0 µM 2.32E-15 2 4.85E-16
2 SGTC_3313 9133968 7.47 57.0 µM 1.54E-13 1 3.96E-14
3 SGTC_2338 7999974 6.79 200.0 µM 1.67E-11 2 5.44E-12
4 SGTC_1061 3448-9325 4.90 110.0 µM 8.82E-7 12 4.91E-7
5 SGTC_2571 chrysanthemic acid 4.15 100.0 µM 2.54E-5 12 1.66E-5
6 SGTC_2334 9017922 4.06 200.0 µM 3.74E-5 21 2.49E-5
7 SGTC_3219 9131112 3.96 49.5 µM 5.56E-5 Golgi 34 3.78E-5
8 SGTC_3335 9143315 3.91 29.6 µM 6.70E-5 fatty acid desaturase (OLE1) 14 4.59E-5
9 SGTC_996 3970-0799 3.86 1.8 µM 8.07E-5 86 5.58E-5
10 SGTC_1971 st069429 3.83 63.5 µM 9.08E-5 60S ribosome export 17 6.31E-5
11 SGTC_319 1348-1596 3.63 45.5 µM 1.97E-4 RSC & ERG11 24 1.42E-4
12 SGTC_916 4466-0038 3.61 42.0 nM 2.12E-4 cell wall 85 1.53E-4
13 SGTC_998 3996-0085 3.54 177.0 µM 2.72E-4 35 1.99E-4
14 SGTC_1160 4092-0570 3.46 10.5 µM 3.61E-4 plasma membrane duress 57 2.68E-4
15 SGTC_2629 bisabolol 3.41 100.0 µM 4.41E-4 38 3.30E-4
16 SGTC_2592 piperlongumine 3.32 83.3 µM 5.99E-4 TSC3-RPN4 66 4.55E-4
17 SGTC_2843 9000894 3.28 45.5 µM 6.83E-4 17 5.22E-4
18 SGTC_930 2810-3379 3.24 265.0 µM 7.82E-4 30 6.01E-4
19 SGTC_939 1165-0479 3.22 45.3 µM 8.42E-4 71 6.50E-4
20 SGTC_1798 st045719 3.22 61.0 µM 8.42E-4 22 6.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.07E-17 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.143 7.53E-17 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.137 1.60E-15 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.135 4.77E-15 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.132 1.76E-14 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.129 6.67E-14 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.128 8.69E-14 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.122 1.11E-12 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.116 1.41E-11 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.114 3.39E-11 YGL034C_d YGL034C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 3.57E-11 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
0.113 6.02E-11 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.111 1.34E-10 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
0.109 2.42E-10 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.107 5.66E-10 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci