HIPHOP chemogenomics database

YIL062C / ARC15

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity

Zygosity: Heterozygous strain

fixedexpanded
Profile for YIL062C / ARC15

Click on Significant Values for Screen Details

Top fitness defect scores for YIL062C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2986	9022445	5.85	71.4 µM	1.36E-10		2	2.41E-9	1.43
2	SGTC_1636	st007707	5.71	68.9 µM	3.74E-10		3	5.79E-9	1.01
3	SGTC_1630	st005209	5.38	31.3 µM	3.13E-9		1	3.63E-8	0.72
4	SGTC_69	0096-0274	5.29	206.7 µM	5.55E-9	mitochondrial processes	27	5.96E-8	0.01
5	SGTC_1047	2043-3044	5.10	82.0 µM	1.82E-8		3	1.66E-7	0.97
6	SGTC_3222	9128301	4.90	49.5 µM	6.03E-8	60S ribosome export	5	4.68E-7	0.64
7	SGTC_1057	3448-5381	4.60	134.0 µM	3.46E-7	calcium & mitochondrial duress	12	2.12E-6	0.17
8	SGTC_3316	9136639	4.52	10.6 µM	5.43E-7		3	3.13E-6	0.66
9	SGTC_937	3122-0005	4.26	46.7 µM	2.09E-6		5	1.01E-5	0.56
10	SGTC_2307	7538926	4.02	6.3 µM	6.96E-6		21	2.85E-5	0.04
11	SGTC_2611	pyromycin	3.87	23.9 µM	1.48E-5		5	5.48E-5	0.04
12	SGTC_1860	st056228	3.85	74.6 µM	1.59E-5		6	5.82E-5	0.11
13	SGTC_355	1311-2252	3.76	105.0 µM	2.41E-5		3	8.36E-5	0.21
14	SGTC_679	0422-0091	3.68	41.4 µM	3.56E-5	Golgi	14	1.17E-4	0.02
15	SGTC_2241	6772625	3.66	37.8 µM	3.90E-5		11	1.27E-4	5.65E-4
16	SGTC_1760	st045453	3.63	10.4 µM	4.37E-5	NEO1-PIK1	4	1.40E-4	0.02
17	SGTC_625	k213-0058	3.54	121.0 µM	6.72E-5	translation	23	2.03E-4	0.01
18	SGTC_961	1252-1571	3.53	372.0 µM	7.00E-5		7	2.11E-4	0.01
19	SGTC_1647	st011722	3.52	22.4 µM	7.16E-5		13	2.15E-4	0.33
20	SGTC_1051	3253-3903	3.51	78.0 µM	7.36E-5		10	2.20E-4	0.31

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.108	3.64E-10	YAL017W	PSK1	hom	PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.105	1.19E-9	YML097C	VPS9	hom	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.097	1.71E-8	YOR351C	MEK1	hom	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
0.087	4.01E-7	YMR253C_p	YMR253C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.084	1.19E-6	YMR326C_d	YMR326C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.079	4.65E-6	YMR316C-B_d	YMR316C-B_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078	5.85E-6	YDL017W	CDC7	het	DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p
0.077	8.54E-6	YKL017C	HCS1	hom	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.074	1.69E-5	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.074	1.74E-5	YHR046C	INM1	hom	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.074	1.82E-5	YOR225W_d	YOR225W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073	2.07E-5	YJR023C_d	YJR023C_d	het	Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.073	2.23E-5	YBL030C	PET9	het	Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.073	2.42E-5	YNL152W	INN1	het	Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.073	2.47E-5	YIL152W_p	YIL152W_p	hom	Putative protein of unknown function