YIL069C / RPS24B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL069C / RPS24B

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:2.87|P-value:8.29E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.24|P-value:1.65E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.73|P-value:2.20E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.01|P-value:4.82E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.64|P-value:3.43E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:2.91|P-value:7.13E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:2.98|P-value:5.46E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.18|P-value:2.45E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.56|P-value:4.70E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.35|P-value:1.24E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.68|P-value:1.50E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:3.97E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.05|P-value:4.69E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:2.90|P-value:7.29E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.38|P-value:1.09E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.98|P-value:5.33E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.24|P-value:1.90E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.18|P-value:7.02E-9 ID:SGTC_718|Compound:1130-0073|FD-Score:3.48|P-value:6.83E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.27|P-value:1.66E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.86|P-value:8.89E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.72|P-value:1.26E-7 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:6.71|P-value:1.00E-13 ID:SGTC_1476|Compound:4112-3294|FD-Score:-2.85|P-value:9.30E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:2.94|P-value:6.38E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.74|P-value:2.04E-5 ID:SGTC_1774|Compound:st048371|FD-Score:-3.15|P-value:2.93E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-2.98|P-value:5.70E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.73|P-value:2.32E-5 ID:SGTC_1816|Compound:st051957|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.13|P-value:2.96E-4 ID:SGTC_1923|Compound:st058458|FD-Score:7.19|P-value:1.69E-15 ID:SGTC_1935|Compound:st074532|FD-Score:3.81|P-value:1.45E-5 ID:SGTC_1936|Compound:st074407|FD-Score:-4.37|P-value:8.90E-7 ID:SGTC_2040|Compound:5100729|FD-Score:3.01|P-value:4.84E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-2.87|P-value:8.52E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.22|P-value:2.08E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.92|P-value:8.83E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-3.10|P-value:3.56E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.21|P-value:2.24E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.52|P-value:5.88E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.95|P-value:6.19E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.03|P-value:4.69E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.88|P-value:5.79E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.39|P-value:1.28E-12 ID:SGTC_2817|Compound:7995342|FD-Score:3.36|P-value:1.16E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.21|P-value:2.15E-4 ID:SGTC_2874|Compound:9043904|FD-Score:2.85|P-value:8.85E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.55|P-value:5.07E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.78|P-value:1.80E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.03|P-value:4.44E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:2.87|P-value:8.29E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.24|P-value:1.65E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.73|P-value:2.20E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.01|P-value:4.82E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.64|P-value:3.43E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:2.91|P-value:7.13E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:2.98|P-value:5.46E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.18|P-value:2.45E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.56|P-value:4.70E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.35|P-value:1.24E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.68|P-value:1.50E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.52|P-value:3.97E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.05|P-value:4.69E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:2.90|P-value:7.29E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.38|P-value:1.09E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:2.98|P-value:5.33E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.24|P-value:1.90E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.18|P-value:7.02E-9 ID:SGTC_718|Compound:1130-0073|FD-Score:3.48|P-value:6.83E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.27|P-value:1.66E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-2.86|P-value:8.89E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.72|P-value:1.26E-7 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:6.71|P-value:1.00E-13 ID:SGTC_1476|Compound:4112-3294|FD-Score:-2.85|P-value:9.30E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:2.94|P-value:6.38E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.74|P-value:2.04E-5 ID:SGTC_1774|Compound:st048371|FD-Score:-3.15|P-value:2.93E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-2.98|P-value:5.70E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.73|P-value:2.32E-5 ID:SGTC_1816|Compound:st051957|FD-Score:2.96|P-value:5.90E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.13|P-value:2.96E-4 ID:SGTC_1923|Compound:st058458|FD-Score:7.19|P-value:1.69E-15 ID:SGTC_1935|Compound:st074532|FD-Score:3.81|P-value:1.45E-5 ID:SGTC_1936|Compound:st074407|FD-Score:-4.37|P-value:8.90E-7 ID:SGTC_2040|Compound:5100729|FD-Score:3.01|P-value:4.84E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-2.87|P-value:8.52E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.22|P-value:2.08E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.92|P-value:8.83E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-3.10|P-value:3.56E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.21|P-value:2.24E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.52|P-value:5.88E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.95|P-value:6.19E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.03|P-value:4.69E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.88|P-value:5.79E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.39|P-value:1.28E-12 ID:SGTC_2817|Compound:7995342|FD-Score:3.36|P-value:1.16E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.21|P-value:2.15E-4 ID:SGTC_2874|Compound:9043904|FD-Score:2.85|P-value:8.85E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.55|P-value:5.07E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.78|P-value:1.80E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.03|P-value:4.44E-4

Top fitness defect scores for YIL069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1923 st058458 7.19 19.1 µM 1.69E-15 5 3.26E-13
2 SGTC_1309 pyrazolanthrone 6.71 13.4 µM 1.00E-13 6 9.93E-12
3 SGTC_2688 kanamycin b 6.39 96.7 µM 1.28E-12 calcium & mitochondrial duress 136 8.38E-11
4 SGTC_2651 1327-0036 5.88 5.0 µM 5.79E-11 77 2.03E-9
5 SGTC_710 3448-4187 5.18 58.0 µM 7.02E-9 fatty acid desaturase (OLE1) 24 1.13E-7
6 SGTC_309 k408-0051 4.68 1.5 µM 1.50E-7 34 1.47E-6
7 SGTC_65 0798-0905 4.24 35.0 µM 1.65E-6 calcium & mitochondrial duress 78 1.10E-5
8 SGTC_2358 9037157 3.92 4.0 µM 8.83E-6 32 4.51E-5
9 SGTC_1935 st074532 3.81 41.6 µM 1.45E-5 37 6.83E-5
10 SGTC_1734 st037168 3.74 69.4 µM 2.04E-5 33 9.10E-5
11 SGTC_150 3970-0969 3.73 77.2 µM 2.20E-5 73 9.70E-5
12 SGTC_246 cycloheximide 3.56 667.0 µM 4.70E-5 24 1.84E-4
13 SGTC_2941 9056145 3.55 11.2 µM 5.07E-5 27 1.96E-4
14 SGTC_718 1130-0073 3.48 349.0 µM 6.83E-5 30 2.52E-4
15 SGTC_2817 7995342 3.36 71.4 µM 1.16E-4 42 3.93E-4
16 SGTC_791 1348-1292 3.31 225.0 µM 1.40E-4 71 4.62E-4
17 SGTC_817 1391-0715 3.27 46.0 µM 1.66E-4 38 5.32E-4
18 SGTC_699 0375-0592 3.24 111.0 µM 1.90E-4 iron homeostasis 50 5.95E-4
19 SGTC_2331 7980721 3.22 200.0 µM 2.08E-4 60 6.43E-4
20 SGTC_2856 9022925 3.21 19.5 µM 2.15E-4 55 6.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 1.67E-69 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.248 4.28E-48 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.197 9.68E-31 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.194 1.10E-29 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.184 4.64E-27 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.171 1.65E-23 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.164 9.83E-22 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.163 1.88E-21 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.162 3.13E-21 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.157 7.69E-20 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.155 1.30E-19 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.154 3.29E-19 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.152 7.90E-19 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.152 9.47E-19 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.150 2.66E-18 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria