YIL070C / MAM33

Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL070C / MAM33

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:3.84|P-value:2.37E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.67|P-value:1.12E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.59|P-value:5.37E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.64|P-value:2.38E-12 ID:SGTC_195|Compound:4234-0266|FD-Score:3.54|P-value:6.23E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.25|P-value:5.53E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:14.60|P-value:4.17E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.73|P-value:1.03E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:6.82|P-value:3.25E-10 ID:SGTC_470|Compound:aa-861|FD-Score:-3.53|P-value:8.55E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.81|P-value:3.45E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.41|P-value:9.45E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.59|P-value:5.42E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.56|P-value:5.88E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.71|P-value:9.46E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:4.49|P-value:2.24E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.14|P-value:8.37E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.87|P-value:2.13E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.75|P-value:3.25E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.53|P-value:6.49E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.98|P-value:3.10E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.49|P-value:7.40E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.46|P-value:7.99E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.60|P-value:6.72E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.40|P-value:1.80E-11 ID:SGTC_1731|Compound:st035964|FD-Score:-3.94|P-value:2.23E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.43|P-value:6.09E-7 ID:SGTC_2005|Compound:4024620|FD-Score:3.45|P-value:8.32E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.70|P-value:9.88E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.75|P-value:3.18E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.42|P-value:9.09E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.72|P-value:9.17E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.59|P-value:5.37E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.92|P-value:4.02E-6 ID:SGTC_2276|Compound:7947513|FD-Score:5.50|P-value:3.04E-7 ID:SGTC_2294|Compound:7971431|FD-Score:3.41|P-value:9.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.22|P-value:6.23E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.56|P-value:1.72E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.67|P-value:4.20E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.23|P-value:5.91E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.17|P-value:9.95E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.91|P-value:1.89E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.54|P-value:6.41E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.84|P-value:2.37E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.67|P-value:1.12E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.59|P-value:5.37E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.64|P-value:2.38E-12 ID:SGTC_195|Compound:4234-0266|FD-Score:3.54|P-value:6.23E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.25|P-value:5.53E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:14.60|P-value:4.17E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.73|P-value:1.03E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:6.82|P-value:3.25E-10 ID:SGTC_470|Compound:aa-861|FD-Score:-3.53|P-value:8.55E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.81|P-value:3.45E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.41|P-value:9.45E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.59|P-value:5.42E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.56|P-value:5.88E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.71|P-value:9.46E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:4.49|P-value:2.24E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.14|P-value:8.37E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.87|P-value:2.13E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.75|P-value:3.25E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.53|P-value:6.49E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.98|P-value:3.10E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.49|P-value:7.40E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.46|P-value:7.99E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.60|P-value:6.72E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.40|P-value:1.80E-11 ID:SGTC_1731|Compound:st035964|FD-Score:-3.94|P-value:2.23E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.43|P-value:6.09E-7 ID:SGTC_2005|Compound:4024620|FD-Score:3.45|P-value:8.32E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.70|P-value:9.88E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.75|P-value:3.18E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.42|P-value:9.09E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.72|P-value:9.17E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.59|P-value:5.37E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.92|P-value:4.02E-6 ID:SGTC_2276|Compound:7947513|FD-Score:5.50|P-value:3.04E-7 ID:SGTC_2294|Compound:7971431|FD-Score:3.41|P-value:9.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.22|P-value:6.23E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.56|P-value:1.72E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.67|P-value:4.20E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.23|P-value:5.91E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.17|P-value:9.95E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.91|P-value:1.89E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.54|P-value:6.41E-4

Top fitness defect scores for YIL070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.60 5.3 µM 4.17E-40 105 9.52E-49
2 SGTC_173 1273-0061 7.64 2.7 µM 2.38E-12 mitochondrial stress 76 1.11E-14
3 SGTC_310 1273-0058 6.82 1.1 µM 3.25E-10 mitochondrial stress 123 4.52E-12
4 SGTC_275 trichlorophene 5.73 5.7 µM 1.03E-7 mitochondrial stress 129 5.08E-9
5 SGTC_2276 7947513 5.50 42.1 µM 3.04E-7 7 1.90E-8
6 SGTC_1017 4239-0030 4.98 168.0 µM 3.10E-6 9 3.20E-7
7 SGTC_2267 7931562 4.92 200.0 µM 4.02E-6 5 4.38E-7
8 SGTC_2232 chlorophetanol 4.72 41.5 µM 9.17E-6 TRP & mitochondrial translation 91 1.19E-6
9 SGTC_767 0929-0023 4.71 86.0 µM 9.46E-6 TRP & mitochondrial translation 45 1.24E-6
10 SGTC_2018 5133068 4.70 143.0 µM 9.88E-6 8 1.31E-6
11 SGTC_70 0141-0289 4.67 43.3 µM 1.12E-5 mitochondrial stress 128 1.52E-6
12 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.56 3.7 µM 1.72E-5 45 2.57E-6
13 SGTC_820 1582-0060 4.49 59.9 µM 2.24E-5 22 3.52E-6
14 SGTC_214 4373-3496 4.25 70.0 µM 5.53E-5 49 1.05E-5
15 SGTC_2565 isoliquiritigenin 4.23 100.0 µM 5.91E-5 30 1.14E-5
16 SGTC_2403 6032726 4.22 181.2 µM 6.23E-5 35 1.22E-5
17 SGTC_832 4083-0019 4.14 164.0 µM 8.37E-5 translation 83 1.74E-5
18 SGTC_2785 7756463 3.91 72.7 µM 1.89E-4 29 4.66E-5
19 SGTC_889 0919-1524 3.87 82.7 µM 2.13E-4 15 5.39E-5
20 SGTC_63 0099-0242 3.84 26.7 µM 2.37E-4 mitochondrial stress 92 6.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.472 9.36E-185 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.445 8.37E-163 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.445 1.24E-162 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.432 1.84E-152 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.431 2.73E-151 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.410 4.05E-136 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.410 9.53E-136 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.408 1.59E-134 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.406 2.54E-133 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.405 8.61E-133 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.399 8.80E-129 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.398 9.03E-128 YOR200W_d YOR200W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c
0.398 2.02E-127 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.397 3.16E-127 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.397 6.91E-127 YGR101W PCP1 hom Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases