HIPHOP chemogenomics database

YIL073C / SPO22

Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL073C / SPO22

Click on Significant Values for Screen Details

Top fitness defect scores for YIL073C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_802	4112-3352	5.40	742.0 µM	8.66E-9		5	3.27E-8
2	SGTC_3144	9087057	5.05	49.5 µM	6.82E-8		6	2.25E-7
3	SGTC_931	2812-0076	4.78	566.0 µM	2.99E-7		9	8.94E-7
4	SGTC_535	2293-4129	4.70	48.2 µM	4.43E-7	NEO1	46	1.29E-6
5	SGTC_2185	6113692	4.37	200.0 µM	2.42E-6	ergosterol biosynthesis	11	6.30E-6
6	SGTC_523	1934-0222	4.19	13.7 µM	5.64E-6		28	1.39E-5
7	SGTC_806	3966-4455	4.19	5.9 µM	5.68E-6		16	1.40E-5
8	SGTC_2001	4023502	4.12	57.7 µM	7.87E-6	mitochondrial processes	13	1.89E-5
9	SGTC_1771	st048882	4.03	4.2 µM	1.17E-5	RPP1 & pyrimidine depletion	17	2.75E-5
10	SGTC_906	1165-0455	4.03	526.0 µM	1.19E-5		10	2.78E-5
11	SGTC_378	3970-0959	4.01	8.3 µM	1.30E-5		15	3.03E-5
12	SGTC_2732	terfenadine	3.90	20.0 µM	2.18E-5	ERG2	4	4.89E-5
13	SGTC_2532	xanthone	3.89	78.9 µM	2.24E-5		33	5.02E-5
14	SGTC_3207	9114163	3.78	49.5 µM	3.67E-5		35	7.96E-5
15	SGTC_344	k064-0035	3.70	6.4 µM	5.14E-5	60S ribosome export	26	1.09E-4
16	SGTC_2127	5253358	3.60	187.9 µM	7.78E-5		33	1.60E-4
17	SGTC_3179	9107801	3.52	49.5 µM	1.07E-4		19	2.16E-4
18	SGTC_886	0866-0150	3.48	153.0 µM	1.27E-4		35	2.53E-4
19	SGTC_1440	4100-1550	3.46	40.0 µM	1.35E-4		6	2.67E-4
20	SGTC_2463	5473429	3.41	200.0 µM	1.67E-4	ERG2	30	3.26E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.125	3.35E-13	YGR169C	PUS6	hom	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.094	5.50E-8	YAL002W	VPS8	hom	Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.092	8.50E-8	YLR114C	AVL9	hom	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.089	2.28E-7	YOR004W	UTP23	het	Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.082	2.06E-6	YNL067W-B_p	YNL067W-B_p	hom	Putative protein of unknown function
0.081	2.41E-6	YER137C_p	YER137C_p	hom	Putative protein of unknown function
0.080	3.25E-6	YML121W	GTR1	hom	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.080	3.57E-6	YKR035W-A	DID2	hom	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
0.080	4.01E-6	YJR041C	URB2	het	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.079	4.24E-6	YHR004C	NEM1	hom	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.077	8.32E-6	YGR213C	RTA1	hom	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.074	1.70E-5	YJR066W	TOR1	hom	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.073	2.08E-5	YNR006W	VPS27	hom	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.073	2.20E-5	YIL095W	PRK1	hom	Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication
0.073	2.57E-5	YLR384C	IKI3	hom	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)