HIPHOP chemogenomics database

YIL084C / SDS3

Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL084C / SDS3

Click on Significant Values for Screen Details

Top fitness defect scores for YIL084C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2591	skatole	6.91	100.0 µM	1.68E-11		4	2.43E-12
2	SGTC_1958	st076513	6.15	41.9 µM	1.87E-9	60S ribosome export	10	3.99E-10
3	SGTC_2424	5537928	6.07	59.2 µM	2.84E-9		6	6.25E-10
4	SGTC_2423	st077119	5.75	87.2 µM	1.76E-8		3	4.50E-9
5	SGTC_2934	9036370	5.58	36.9 µM	4.38E-8		12	1.21E-8
6	SGTC_153	4077-0274	4.82	519.7 µM	1.93E-6		7	7.24E-7
7	SGTC_3055	9094636	4.81	49.5 µM	2.00E-6		4	7.54E-7
8	SGTC_1514	1189-1591	4.73	158.0 µM	2.90E-6		24	1.13E-6
9	SGTC_24	0417-1663	4.62	219.0 µM	4.80E-6		11	1.94E-6
10	SGTC_3003	9075612	4.61	71.4 µM	5.05E-6		12	2.05E-6
11	SGTC_3307	9126885	4.56	69.3 µM	6.23E-6		21	2.57E-6
12	SGTC_1316	1272-0050	4.36	65.9 µM	1.49E-5		4	6.59E-6
13	SGTC_1930	st074634	4.26	34.3 µM	2.23E-5	RNA pol III & RNase P/MRP	29	1.02E-5
14	SGTC_1186	1319-0216	4.10	26.0 µM	4.27E-5		17	2.06E-5
15	SGTC_2824	7998404	4.07	52.0 µM	4.88E-5		34	2.39E-5
16	SGTC_2442	5158906	4.01	48.5 µM	6.04E-5		21	3.00E-5
17	SGTC_2687	chenodiol	3.98	100.0 µM	6.76E-5		22	3.39E-5
18	SGTC_734	2023-0417	3.91	80.0 µM	9.14E-5	ergosterol biosynthesis	17	4.70E-5
19	SGTC_2274	7947094	3.88	46.1 µM	9.90E-5		38	5.12E-5
20	SGTC_2936	9038235	3.81	15.6 µM	1.32E-4		22	6.98E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.114	3.10E-11	YER181C_d	YER181C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
0.112	7.39E-11	YMR058W	FET3	hom	Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.111	1.09E-10	YIL117C	PRM5	hom	Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.110	1.57E-10	YDR270W	CCC2	hom	Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.100	5.78E-9	YFL010W-A	AUA1	hom	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
0.100	6.10E-9	YCR091W	KIN82	hom	Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
0.097	2.07E-8	YDR269C_d	YDR269C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095	3.55E-8	YNL259C	ATX1	hom	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.094	4.95E-8	YOR220W	RCN2	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.091	1.19E-7	YDL132W	CDC53	het	Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
0.080	3.08E-6	YLR209C	PNP1	hom	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.079	4.13E-6	YCL051W	LRE1	hom	Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication
0.077	7.76E-6	YLR459W	GAB1	het	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
0.077	9.20E-6	YDR341C	YDR341C	het	Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.076	1.02E-5	YLR224W_p	YLR224W_p	hom	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene