YIL086C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL086C / YIL086C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-4.77|P-value:1.19E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.16|P-value:3.06E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.56|P-value:5.76E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:2.88|P-value:9.51E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-2.97|P-value:6.57E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-2.87|P-value:9.44E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:2.89|P-value:9.26E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.05|P-value:5.77E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:3.12|P-value:3.85E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.07|P-value:4.70E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.89|P-value:1.35E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.88|P-value:8.92E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.36|P-value:1.25E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:2.95|P-value:7.22E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.19|P-value:2.85E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.82|P-value:9.33E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:2.93|P-value:7.73E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-2.86|P-value:9.67E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.84|P-value:1.69E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.12|P-value:3.80E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:2.91|P-value:8.52E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.28|P-value:2.04E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.52|P-value:7.13E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:2.87|P-value:9.75E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.40|P-value:1.20E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.56|P-value:6.18E-5 ID:SGTC_1741|Compound:st038134|FD-Score:4.32|P-value:1.56E-6 ID:SGTC_1744|Compound:st037937|FD-Score:5.98|P-value:5.13E-11 ID:SGTC_1750|Compound:st081859|FD-Score:-3.56|P-value:5.70E-5 ID:SGTC_1893|Compound:st059353|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.95|P-value:7.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.29|P-value:1.86E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.42|P-value:1.10E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.59|P-value:5.36E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:6.69|P-value:2.51E-13 ID:SGTC_2296|Compound:7971656|FD-Score:-3.46|P-value:9.14E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-2.86|P-value:9.58E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.13|P-value:3.52E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.90|P-value:8.91E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.01|P-value:5.48E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.58|P-value:5.33E-5 ID:SGTC_3258|Compound:9138477|FD-Score:3.13|P-value:3.61E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.54|P-value:6.40E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.30|P-value:1.82E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.77|P-value:1.19E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.16|P-value:3.06E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.56|P-value:5.76E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:2.88|P-value:9.51E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-2.97|P-value:6.57E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-2.87|P-value:9.44E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:2.89|P-value:9.26E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.05|P-value:5.77E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:3.12|P-value:3.85E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.07|P-value:4.70E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.89|P-value:1.35E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.88|P-value:8.92E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.36|P-value:1.25E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:2.95|P-value:7.22E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.19|P-value:2.85E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.82|P-value:9.33E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:2.93|P-value:7.73E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-2.86|P-value:9.67E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.84|P-value:1.69E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.12|P-value:3.80E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:2.91|P-value:8.52E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.28|P-value:2.04E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.52|P-value:7.13E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:2.87|P-value:9.75E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.40|P-value:1.20E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.56|P-value:6.18E-5 ID:SGTC_1741|Compound:st038134|FD-Score:4.32|P-value:1.56E-6 ID:SGTC_1744|Compound:st037937|FD-Score:5.98|P-value:5.13E-11 ID:SGTC_1750|Compound:st081859|FD-Score:-3.56|P-value:5.70E-5 ID:SGTC_1893|Compound:st059353|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.95|P-value:7.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.29|P-value:1.86E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.42|P-value:1.10E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.59|P-value:5.36E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:6.69|P-value:2.51E-13 ID:SGTC_2296|Compound:7971656|FD-Score:-3.46|P-value:9.14E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-2.86|P-value:9.58E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.13|P-value:3.52E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.90|P-value:8.91E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.01|P-value:5.48E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.58|P-value:5.33E-5 ID:SGTC_3258|Compound:9138477|FD-Score:3.13|P-value:3.61E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.54|P-value:6.40E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.30|P-value:1.82E-4

Top fitness defect scores for YIL086C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2251 lansoprazole 6.69 556.0 µM 2.51E-13 4 1.12E-11
2 SGTC_1744 st037937 5.98 38.9 µM 5.13E-11 3 1.08E-9
3 SGTC_725 1497-0963 4.36 19.0 µM 1.25E-6 copper-dependent oxidative stress 14 6.49E-6
4 SGTC_1741 st038134 4.32 10.2 µM 1.56E-6 23 7.84E-6
5 SGTC_1951 sophoraflavanone G 4.29 9.2 µM 1.86E-6 RNA processing & uracil transport 15 9.13E-6
6 SGTC_705 1124-0212 3.89 310.0 µM 1.35E-5 16 5.04E-5
7 SGTC_962 1254-0300 3.84 21.5 µM 1.69E-5 26 6.11E-5
8 SGTC_2163 5671233 3.59 125.0 µM 5.36E-5 35 1.66E-4
9 SGTC_1476 4112-3294 3.56 3.3 µM 6.18E-5 60S ribosome export 29 1.88E-4
10 SGTC_1239 0337-0584 3.52 35.4 µM 7.13E-5 unfolded protein response 74 2.12E-4
11 SGTC_1893 st059353 3.44 36.1 µM 1.03E-4 43 2.91E-4
12 SGTC_2110 5483698 3.42 200.0 µM 1.10E-4 TSC3-RPN4 38 3.10E-4
13 SGTC_1417 3966-0327 3.40 90.4 µM 1.20E-4 31 3.33E-4
14 SGTC_3276 9139060 3.30 49.5 µM 1.82E-4 60S ribosome export 16 4.78E-4
15 SGTC_1204 4049-0315 3.28 18.3 µM 2.04E-4 59 5.28E-4
16 SGTC_3102 9121669 3.20 49.5 µM 2.82E-4 23 6.97E-4
17 SGTC_845 0330-0138 3.19 4.5 µM 2.85E-4 43 7.03E-4
18 SGTC_3258 9138477 3.13 49.5 µM 3.61E-4 25 8.64E-4
19 SGTC_966 1300-0360 3.12 30.2 µM 3.80E-4 heme requiring 60 9.03E-4
20 SGTC_548 1436-0017 3.12 110.0 µM 3.85E-4 TSC3-RPN4 72 9.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 2.02E-14 YKR048C NAP1 hom Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
0.125 3.94E-13 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.118 6.91E-12 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.118 7.08E-12 YDR445C_d YDR445C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.49E-11 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.110 1.98E-10 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.102 2.62E-9 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.097 2.03E-8 YER184C_p YER184C_p hom Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
0.096 2.24E-8 YCR036W RBK1 hom Putative ribokinase
0.095 3.00E-8 YDR179W-A_p YDR179W-A_p hom Putative protein of unknown function
0.091 1.37E-7 YDL114W_p YDL114W_p hom Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene
0.090 1.93E-7 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.089 2.38E-7 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.086 6.56E-7 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.085 9.04E-7 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation