YIL089W

Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL089W / YIL089W

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:6.30|P-value:1.25E-13 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.68|P-value:9.53E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.03|P-value:2.11E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-2.74|P-value:7.03E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.23|P-value:8.73E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-2.70|P-value:8.40E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.03|P-value:2.03E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.34|P-value:5.21E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-6.45|P-value:2.90E-14 ID:SGTC_604|Compound:1000-0114|FD-Score:3.45|P-value:3.14E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-2.66|P-value:9.84E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.66|P-value:9.99E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.61|P-value:1.34E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.23|P-value:8.54E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.78|P-value:6.22E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.89|P-value:3.87E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.96|P-value:2.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.74|P-value:6.64E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.78|P-value:6.10E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.17|P-value:1.15E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.42|P-value:3.37E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.46|P-value:2.90E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.73|P-value:1.78E-8 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.83|P-value:5.10E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.16|P-value:1.21E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.01|P-value:2.23E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.70|P-value:8.27E-4 ID:SGTC_1685|Compound:st024049|FD-Score:2.69|P-value:9.08E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.31|P-value:6.18E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.32|P-value:5.83E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.24|P-value:8.05E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.03|P-value:2.16E-4 ID:SGTC_2025|Compound:5147754|FD-Score:2.78|P-value:6.30E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-4.59|P-value:4.64E-8 ID:SGTC_2028|Compound:5153890|FD-Score:-3.27|P-value:6.81E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.30|P-value:6.42E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-2.77|P-value:6.17E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.20|P-value:9.83E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.48|P-value:2.65E-5 ID:SGTC_2693|Compound:st077581|FD-Score:2.75|P-value:7.10E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.73|P-value:7.21E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.17|P-value:1.17E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.00|P-value:2.32E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.18|P-value:6.01E-7 ID:SGTC_2971|Compound:9092186|FD-Score:2.77|P-value:6.66E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.15|P-value:1.21E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.76|P-value:6.36E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-2.88|P-value:4.02E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.76|P-value:6.50E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:6.30|P-value:1.25E-13 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.68|P-value:9.53E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.03|P-value:2.11E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-2.74|P-value:7.03E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.23|P-value:8.73E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-2.70|P-value:8.40E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.03|P-value:2.03E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.34|P-value:5.21E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-6.45|P-value:2.90E-14 ID:SGTC_604|Compound:1000-0114|FD-Score:3.45|P-value:3.14E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-2.66|P-value:9.84E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:2.66|P-value:9.99E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.61|P-value:1.34E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.23|P-value:8.54E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.78|P-value:6.22E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.89|P-value:3.87E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.96|P-value:2.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.74|P-value:6.64E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.78|P-value:6.10E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.17|P-value:1.15E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.42|P-value:3.37E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.46|P-value:2.90E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.73|P-value:1.78E-8 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.83|P-value:5.10E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.16|P-value:1.21E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.01|P-value:2.23E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.70|P-value:8.27E-4 ID:SGTC_1685|Compound:st024049|FD-Score:2.69|P-value:9.08E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.31|P-value:6.18E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.32|P-value:5.83E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.24|P-value:8.05E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.03|P-value:2.16E-4 ID:SGTC_2025|Compound:5147754|FD-Score:2.78|P-value:6.30E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-4.59|P-value:4.64E-8 ID:SGTC_2028|Compound:5153890|FD-Score:-3.27|P-value:6.81E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.30|P-value:6.42E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-2.77|P-value:6.17E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.20|P-value:9.83E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.48|P-value:2.65E-5 ID:SGTC_2693|Compound:st077581|FD-Score:2.75|P-value:7.10E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.73|P-value:7.21E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.17|P-value:1.17E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.00|P-value:2.32E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.18|P-value:6.01E-7 ID:SGTC_2971|Compound:9092186|FD-Score:2.77|P-value:6.66E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.15|P-value:1.21E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.76|P-value:6.36E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-2.88|P-value:4.02E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.76|P-value:6.50E-4

Top fitness defect scores for YIL089W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_182 3448-4371 6.30 550.5 µM 1.25E-13 4 1.47E-10
2 SGTC_2852 9023854 4.18 52.0 µM 6.01E-7 29 1.44E-5
3 SGTC_3202 9113761 3.76 49.5 µM 6.36E-6 54 8.48E-5
4 SGTC_2690 usnic acid 3.48 100.0 µM 2.65E-5 45 2.48E-4
5 SGTC_1294 1000-1494 3.46 117.0 µM 2.90E-5 37 2.66E-4
6 SGTC_604 1000-0114 3.45 314.0 µM 3.14E-5 42 2.82E-4
7 SGTC_519 k048-0011 3.34 62.8 µM 5.21E-5 40 4.13E-4
8 SGTC_1727 st034309 3.32 9.9 µM 5.83E-5 75 4.49E-4
9 SGTC_1691 st019933 3.31 84.6 µM 6.18E-5 32 4.70E-4
10 SGTC_2046 4110841 3.30 106.0 µM 6.42E-5 iron homeostasis 48 4.83E-4
11 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.23 150.0 µM 8.73E-5 Golgi 70 6.09E-4
12 SGTC_1270 0831-1170 3.17 17.3 µM 1.15E-4 35 7.52E-4
13 SGTC_2790 5423970 3.17 71.4 µM 1.17E-4 endomembrane recycling 105 7.60E-4
14 SGTC_1312 1218-2183 3.16 165.0 µM 1.21E-4 21 7.79E-4
15 SGTC_1998 st075797 3.03 76.8 µM 2.16E-4 mitochondrial response to ROS 49 0.00121
16 SGTC_1059 3448-6867 2.96 171.0 µM 2.92E-4 49 0.00152
17 SGTC_1306 1185-0270 2.83 9.0 µM 5.10E-4 Golgi 102 0.00232
18 SGTC_798 1287-0182 2.78 476.0 µM 6.22E-4 86 0.00269
19 SGTC_2025 5147754 2.78 141.0 µM 6.30E-4 53 0.00272
20 SGTC_2971 9092186 2.77 9.9 µM 6.66E-4 ergosterol biosynthesis 82 0.00283

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.39E-25 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.172 1.02E-23 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.165 6.97E-22 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.142 1.23E-16 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.141 1.77E-16 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.137 1.29E-15 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.125 3.70E-13 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.124 6.19E-13 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.22E-12 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.117 1.00E-11 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.117 1.10E-11 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.114 3.67E-11 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.113 4.83E-11 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.113 4.93E-11 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.112 6.78E-11 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome