YIL098C / FMC1

Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL098C / FMC1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:3.96|P-value:6.41E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.28|P-value:6.62E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.62|P-value:3.93E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:5.27|P-value:1.76E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:6.42|P-value:2.60E-10 ID:SGTC_309|Compound:k408-0051|FD-Score:4.83|P-value:1.50E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.04|P-value:3.92E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.69|P-value:1.57E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.87|P-value:7.71E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.77|P-value:1.61E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:3.86|P-value:9.50E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.29|P-value:1.23E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:5.51|P-value:4.85E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.44|P-value:4.56E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.79|P-value:1.83E-6 ID:SGTC_881|Compound:0833-0569|FD-Score:4.07|P-value:4.23E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.61|P-value:4.18E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:3.59|P-value:2.65E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.52|P-value:3.44E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.40|P-value:5.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.87|P-value:6.64E-9 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.22|P-value:2.25E-7 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.78|P-value:1.11E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.46|P-value:3.62E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.27|P-value:1.87E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.56|P-value:2.99E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.48|P-value:7.35E-6 ID:SGTC_1635|Compound:st007035|FD-Score:15.50|P-value:1.86E-51 ID:SGTC_1707|Compound:st032323|FD-Score:3.49|P-value:3.77E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.65|P-value:2.09E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.47|P-value:4.11E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.31|P-value:7.08E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.51|P-value:3.53E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.01|P-value:6.33E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.27|P-value:6.87E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-4.28|P-value:1.46E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.36|P-value:5.96E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.25|P-value:8.70E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.12|P-value:3.70E-7 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.77|P-value:1.19E-8 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.53|P-value:2.80E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.24|P-value:2.07E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.74|P-value:1.50E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.08|P-value:4.12E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.27|P-value:1.69E-7 ID:SGTC_2812|Compound:7970281|FD-Score:4.26|P-value:1.95E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.25|P-value:8.62E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.63|P-value:1.95E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.40|P-value:5.16E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-5.17|P-value:2.32E-7 ID:SGTC_3341|Compound:9147222|FD-Score:3.44|P-value:4.45E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.96|P-value:6.41E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.28|P-value:6.62E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.62|P-value:3.93E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:5.27|P-value:1.76E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:6.42|P-value:2.60E-10 ID:SGTC_309|Compound:k408-0051|FD-Score:4.83|P-value:1.50E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.04|P-value:3.92E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.69|P-value:1.57E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.87|P-value:7.71E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.77|P-value:1.61E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:3.86|P-value:9.50E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.29|P-value:1.23E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:5.51|P-value:4.85E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.44|P-value:4.56E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.79|P-value:1.83E-6 ID:SGTC_881|Compound:0833-0569|FD-Score:4.07|P-value:4.23E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.61|P-value:4.18E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:3.59|P-value:2.65E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.52|P-value:3.44E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.40|P-value:5.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.87|P-value:6.64E-9 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.22|P-value:2.25E-7 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.78|P-value:1.11E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.46|P-value:3.62E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.27|P-value:1.87E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.56|P-value:2.99E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.48|P-value:7.35E-6 ID:SGTC_1635|Compound:st007035|FD-Score:15.50|P-value:1.86E-51 ID:SGTC_1707|Compound:st032323|FD-Score:3.49|P-value:3.77E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.65|P-value:2.09E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.47|P-value:4.11E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.31|P-value:7.08E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.51|P-value:3.53E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.01|P-value:6.33E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.27|P-value:6.87E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-4.28|P-value:1.46E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.36|P-value:5.96E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.25|P-value:8.70E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.12|P-value:3.70E-7 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.77|P-value:1.19E-8 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.53|P-value:2.80E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.24|P-value:2.07E-5 ID:SGTC_2708|Compound:st078559|FD-Score:3.74|P-value:1.50E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.08|P-value:4.12E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.27|P-value:1.69E-7 ID:SGTC_2812|Compound:7970281|FD-Score:4.26|P-value:1.95E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.25|P-value:8.62E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.50|P-value:3.65E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.63|P-value:1.95E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.40|P-value:5.16E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-5.17|P-value:2.32E-7 ID:SGTC_3341|Compound:9147222|FD-Score:3.44|P-value:4.45E-4

Top fitness defect scores for YIL098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 15.50 42.4 µM 1.86E-51 34 1.53E-54
2 SGTC_236 1509-0011 6.42 5.3 µM 2.60E-10 281 6.93E-11
3 SGTC_1083 didemethylchlorpromazine sulfoxide 5.87 707.4 nM 6.64E-9 redox potentiating 29 2.16E-9
4 SGTC_2499 avocadenofuran 5.77 51.5 µM 1.19E-8 10 4.00E-9
5 SGTC_739 1486-1183 5.51 203.0 µM 4.85E-8 3 1.78E-8
6 SGTC_2753 fluvastatin 5.27 17.1 µM 1.69E-7 azole & statin 11 6.70E-8
7 SGTC_168 3970-0862 5.27 530.5 µM 1.76E-7 63 6.99E-8
8 SGTC_1191 1487-1166 5.22 10.6 µM 2.25E-7 azole & statin 16 9.12E-8
9 SGTC_2328 6201408 5.12 200.0 µM 3.70E-7 8 1.54E-7
10 SGTC_2248 tofa 5.01 1.1 µM 6.33E-7 sphingolipid biosynthesis & PDR1 26 2.73E-7
11 SGTC_309 k408-0051 4.83 1.5 µM 1.50E-6 31 6.81E-7
12 SGTC_778 3456-2434 4.79 196.0 µM 1.83E-6 mitochondrial response to ROS 51 8.42E-7
13 SGTC_150 3970-0969 4.62 77.2 µM 3.93E-6 40 1.90E-6
14 SGTC_887 0885-0007 4.61 9.6 µM 4.18E-6 endomembrane recycling 25 2.03E-6
15 SGTC_1522 st012842 4.48 45.6 µM 7.35E-6 RNA pol III & RNase P/MRP 18 3.69E-6
16 SGTC_1475 4092-1048 4.27 11.7 µM 1.87E-5 plasma membrane duress 25 9.95E-6
17 SGTC_2812 7970281 4.26 58.4 µM 1.95E-5 21 1.04E-5
18 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 4.24 100.0 µM 2.07E-5 16 1.11E-5
19 SGTC_2752 diclazuril 4.08 33.1 µM 4.12E-5 113 2.30E-5
20 SGTC_881 0833-0569 4.07 170.0 µM 4.23E-5 25 2.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.397 9.44E-127 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.361 3.67E-104 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.350 1.52E-97 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.349 2.08E-96 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.341 3.67E-92 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.340 8.71E-92 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.338 1.13E-90 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.328 4.81E-85 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.323 4.88E-82 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.314 2.25E-77 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.298 6.61E-70 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.296 6.37E-69 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.295 2.02E-68 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.291 2.51E-66 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.289 1.19E-65 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry