HIPHOP chemogenomics database

YIL100W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL100W / YIL100W

Click on Significant Values for Screen Details

Top fitness defect scores for YIL100W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_523	1934-0222	8.00	13.7 µM	6.90E-15		4	6.02E-16
2	SGTC_1628	st004252	4.46	77.7 µM	9.08E-6		10	4.15E-6
3	SGTC_315	k915-0449	4.26	187.0 µM	2.08E-5		49	1.01E-5
4	SGTC_1174	0739-0097	3.64	51.1 µM	2.33E-4	redox potentiating	45	1.37E-4
5	SGTC_526	4469-0568	3.61	170.0 µM	2.59E-4	azole & statin	45	1.53E-4
6	SGTC_2293	7624732	3.60	200.0 µM	2.64E-4		37	1.56E-4
7	SGTC_1534	6-azauridine	3.51	81.6 µM	3.72E-4	RNA pol III & RNase P/MRP	44	2.26E-4
8	SGTC_1083	didemethylchlorpromazine sulfoxide	3.39	707.4 nM	5.66E-4	redox potentiating	117	3.55E-4
9	SGTC_2283	7944793	3.37	200.0 µM	5.89E-4		71	3.71E-4
10	SGTC_2939	9044578	3.25	71.4 µM	8.96E-4		67	5.82E-4
11	SGTC_2760	etidronate	3.16	98.0 µM	0.00119		62	7.90E-4
12	SGTC_2756	carbadox	3.15	75.1 µM	0.00122		105	8.11E-4
13	SGTC_2282	7944268	3.13	200.0 µM	0.00132	RPP1 & pyrimidine depletion	78	8.83E-4
14	SGTC_409	arachidonic acid	3.06	100.0 µM	0.00162		40	0.00110
15	SGTC_1763	st044482	3.03	94.5 µM	0.00180	copper-dependent oxidative stress	52	0.00123
16	SGTC_2694	st077685	2.96	81.9 µM	0.00218	endomembrane recycling	77	0.00151
17	SGTC_390	dec-rvkr-cmk	2.94	16.7 µM	0.00233	calcium & mitochondrial duress	80	0.00163
18	SGTC_521	r062-0005	2.84	13.8 µM	0.00312		65	0.00222
19	SGTC_425	3825-7017	2.83	13.1 µM	0.00329		97	0.00236
20	SGTC_160	3453-0671	2.82	289.7 µM	0.00335		106	0.00240

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.157	7.98E-20	YNL149C	PGA2	het	Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.135	3.37E-15	YPL251W_d	YPL251W_d	het	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.123	7.62E-13	YPR075C	OPY2	hom	Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress
0.114	4.07E-11	YPL252C	YAH1	het	Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.104	1.53E-9	YOR267C	HRK1	hom	Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.097	2.03E-8	YDR066C	RTR2	hom	Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
0.095	3.16E-8	YPL012W	RRP12	het	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.095	3.94E-8	YMR026C	PEX12	hom	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.093	5.78E-8	YNL150W_d	YNL150W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.091	1.46E-7	YPR022C_p	YPR022C_p	hom	Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.083	1.55E-6	YOL014W_p	YOL014W_p	hom	Putative protein of unknown function
0.082	1.78E-6	YDR431W_d	YDR431W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081	2.86E-6	YKL124W	SSH4	hom	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.081	2.96E-6	YFR026C	ULI1	hom	Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.080	3.82E-6	YIR024C	YIR024C	hom	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect