YIL100W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL100W / YIL100W

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-4.74|P-value:2.58E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.26|P-value:2.08E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.33|P-value:6.87E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.52|P-value:3.57E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:8.00|P-value:6.90E-15 ID:SGTC_526|Compound:4469-0568|FD-Score:3.61|P-value:2.59E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.67|P-value:2.06E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.39|P-value:5.66E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.36|P-value:6.16E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.86|P-value:1.00E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.30|P-value:7.54E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.31|P-value:7.30E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.64|P-value:2.33E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-4.85|P-value:1.52E-6 ID:SGTC_1351|Compound:1496-0003|FD-Score:-4.46|P-value:8.72E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.79|P-value:1.31E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.51|P-value:3.72E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.46|P-value:9.08E-6 ID:SGTC_2283|Compound:7944793|FD-Score:3.37|P-value:5.89E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.60|P-value:2.64E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.97|P-value:6.65E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.93|P-value:7.84E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.67|P-value:2.10E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.91|P-value:8.58E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.25|P-value:8.96E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.28|P-value:7.92E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-4.74|P-value:2.58E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.26|P-value:2.08E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.33|P-value:6.87E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.52|P-value:3.57E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:8.00|P-value:6.90E-15 ID:SGTC_526|Compound:4469-0568|FD-Score:3.61|P-value:2.59E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.67|P-value:2.06E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.39|P-value:5.66E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.36|P-value:6.16E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.86|P-value:1.00E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.30|P-value:7.54E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.31|P-value:7.30E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.64|P-value:2.33E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-4.85|P-value:1.52E-6 ID:SGTC_1351|Compound:1496-0003|FD-Score:-4.46|P-value:8.72E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.79|P-value:1.31E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.51|P-value:3.72E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.46|P-value:9.08E-6 ID:SGTC_2283|Compound:7944793|FD-Score:3.37|P-value:5.89E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.60|P-value:2.64E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.97|P-value:6.65E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.93|P-value:7.84E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.67|P-value:2.10E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.91|P-value:8.58E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.25|P-value:8.96E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.28|P-value:7.92E-4

Top fitness defect scores for YIL100W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_523 1934-0222 8.00 13.7 µM 6.90E-15 4 6.02E-16
2 SGTC_1628 st004252 4.46 77.7 µM 9.08E-6 10 4.15E-6
3 SGTC_315 k915-0449 4.26 187.0 µM 2.08E-5 49 1.01E-5
4 SGTC_1174 0739-0097 3.64 51.1 µM 2.33E-4 redox potentiating 45 1.37E-4
5 SGTC_526 4469-0568 3.61 170.0 µM 2.59E-4 azole & statin 45 1.53E-4
6 SGTC_2293 7624732 3.60 200.0 µM 2.64E-4 37 1.56E-4
7 SGTC_1534 6-azauridine 3.51 81.6 µM 3.72E-4 RNA pol III & RNase P/MRP 44 2.26E-4
8 SGTC_1083 didemethylchlorpromazine sulfoxide 3.39 707.4 nM 5.66E-4 redox potentiating 117 3.55E-4
9 SGTC_2283 7944793 3.37 200.0 µM 5.89E-4 71 3.71E-4
10 SGTC_2939 9044578 3.25 71.4 µM 8.96E-4 67 5.82E-4
11 SGTC_2760 etidronate 3.16 98.0 µM 0.00119 62 7.90E-4
12 SGTC_2756 carbadox 3.15 75.1 µM 0.00122 105 8.11E-4
13 SGTC_2282 7944268 3.13 200.0 µM 0.00132 RPP1 & pyrimidine depletion 78 8.83E-4
14 SGTC_409 arachidonic acid 3.06 100.0 µM 0.00162 40 0.00110
15 SGTC_1763 st044482 3.03 94.5 µM 0.00180 copper-dependent oxidative stress 52 0.00123
16 SGTC_2694 st077685 2.96 81.9 µM 0.00218 endomembrane recycling 77 0.00151
17 SGTC_390 dec-rvkr-cmk 2.94 16.7 µM 0.00233 calcium & mitochondrial duress 80 0.00163
18 SGTC_521 r062-0005 2.84 13.8 µM 0.00312 65 0.00222
19 SGTC_425 3825-7017 2.83 13.1 µM 0.00329 97 0.00236
20 SGTC_160 3453-0671 2.82 289.7 µM 0.00335 106 0.00240

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 7.98E-20 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.135 3.37E-15 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.123 7.62E-13 YPR075C OPY2 hom Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress
0.114 4.07E-11 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.104 1.53E-9 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.097 2.03E-8 YDR066C RTR2 hom Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
0.095 3.16E-8 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.095 3.94E-8 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.093 5.78E-8 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.091 1.46E-7 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.083 1.55E-6 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.082 1.78E-6 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.86E-6 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.081 2.96E-6 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.080 3.82E-6 YIR024C YIR024C hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect