YIL102C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL102C / YIL102C

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:3.58|P-value:9.35E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.13|P-value:5.42E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.48|P-value:1.62E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.34|P-value:2.50E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.44|P-value:1.65E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.77|P-value:4.26E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.70|P-value:5.59E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.33|P-value:2.54E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.91|P-value:2.24E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.90|P-value:2.34E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.34|P-value:2.86E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.02|P-value:7.92E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.00|P-value:8.66E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.60|P-value:8.45E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.58|P-value:9.40E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.17|P-value:6.89E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:3.32|P-value:2.65E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.54|P-value:1.10E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.58|P-value:8.91E-7 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.03|P-value:8.93E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.10|P-value:5.93E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.03|P-value:8.99E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.05|P-value:1.23E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-4.97|P-value:1.41E-7 ID:SGTC_1720|Compound:st037298|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.03|P-value:8.90E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.76|P-value:4.31E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.71|P-value:5.43E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.65|P-value:7.10E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.91|P-value:2.31E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.12|P-value:6.41E-4 ID:SGTC_2448|Compound:5185112|FD-Score:5.17|P-value:3.67E-8 ID:SGTC_2467|Compound:5474540|FD-Score:-4.34|P-value:3.55E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.18|P-value:4.55E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:-3.00|P-value:9.83E-4 ID:SGTC_2683|Compound:piperine|FD-Score:-3.23|P-value:4.24E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.09|P-value:1.19E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.09|P-value:9.98E-6 ID:SGTC_2827|Compound:7993847|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.80|P-value:3.71E-5 ID:SGTC_2842|Compound:9000675|FD-Score:4.22|P-value:5.42E-6 ID:SGTC_2843|Compound:9000894|FD-Score:3.99|P-value:1.58E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.75|P-value:5.35E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.56|P-value:1.00E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.07|P-value:7.60E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.85|P-value:2.99E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.60|P-value:8.37E-7 ID:SGTC_3157|Compound:9099274|FD-Score:4.08|P-value:1.07E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.16|P-value:4.88E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.58|P-value:9.35E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.13|P-value:5.42E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:-3.48|P-value:1.62E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.34|P-value:2.50E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.44|P-value:1.65E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.77|P-value:4.26E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.70|P-value:5.59E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.33|P-value:2.54E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.91|P-value:2.24E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.90|P-value:2.34E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.34|P-value:2.86E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.02|P-value:7.92E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.00|P-value:8.66E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.60|P-value:8.45E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.58|P-value:9.40E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.17|P-value:6.89E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:3.32|P-value:2.65E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.54|P-value:1.10E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.58|P-value:8.91E-7 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.03|P-value:8.93E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.10|P-value:5.93E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.03|P-value:8.99E-4 ID:SGTC_1630|Compound:st005209|FD-Score:4.05|P-value:1.23E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-4.97|P-value:1.41E-7 ID:SGTC_1720|Compound:st037298|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.03|P-value:8.90E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.76|P-value:4.31E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.71|P-value:5.43E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.65|P-value:7.10E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.91|P-value:2.31E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.12|P-value:6.41E-4 ID:SGTC_2448|Compound:5185112|FD-Score:5.17|P-value:3.67E-8 ID:SGTC_2467|Compound:5474540|FD-Score:-4.34|P-value:3.55E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.18|P-value:4.55E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:-3.00|P-value:9.83E-4 ID:SGTC_2683|Compound:piperine|FD-Score:-3.23|P-value:4.24E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.09|P-value:1.19E-5 ID:SGTC_2819|Compound:7996655|FD-Score:4.09|P-value:9.98E-6 ID:SGTC_2827|Compound:7993847|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.80|P-value:3.71E-5 ID:SGTC_2842|Compound:9000675|FD-Score:4.22|P-value:5.42E-6 ID:SGTC_2843|Compound:9000894|FD-Score:3.99|P-value:1.58E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-3.75|P-value:5.35E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.56|P-value:1.00E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-3.07|P-value:7.60E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.85|P-value:2.99E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.60|P-value:8.37E-7 ID:SGTC_3157|Compound:9099274|FD-Score:4.08|P-value:1.07E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.16|P-value:4.88E-4

Top fitness defect scores for YIL102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2448 5185112 5.17 27.2 µM 3.67E-8 6 1.19E-7
2 SGTC_3149 9097855 4.60 49.5 µM 8.37E-7 Golgi 13 2.16E-6
3 SGTC_1568 digitonin 4.58 820.0 nM 8.91E-7 sphingolipid biosynthesis & PDR1 22 2.29E-6
4 SGTC_2842 9000675 4.22 19.5 µM 5.42E-6 18 1.22E-5
5 SGTC_1515 3460-0031 4.17 42.1 µM 6.89E-6 DNA intercalators 14 1.53E-5
6 SGTC_2819 7996655 4.09 46.4 µM 9.98E-6 20 2.15E-5
7 SGTC_3157 9099274 4.08 49.5 µM 1.07E-5 19 2.29E-5
8 SGTC_1630 st005209 4.05 31.3 µM 1.23E-5 24 2.60E-5
9 SGTC_2843 9000894 3.99 45.5 µM 1.58E-5 11 3.30E-5
10 SGTC_745 0469-0705 3.91 296.0 µM 2.24E-5 mitochondrial processes 23 4.55E-5
11 SGTC_2309 7664088 3.91 163.9 µM 2.31E-5 33 4.69E-5
12 SGTC_810 3825-7150 3.90 143.0 µM 2.34E-5 60S ribosome export 9 4.74E-5
13 SGTC_3135 9127742 3.85 49.5 µM 2.99E-5 26 5.94E-5
14 SGTC_2829 7992743 3.80 58.4 µM 3.71E-5 44 7.27E-5
15 SGTC_651 3253-0966 3.77 34.4 µM 4.26E-5 calcium & mitochondrial duress 38 8.27E-5
16 SGTC_1845 st056753 3.76 3.0 µM 4.31E-5 TSC3-RPN4 43 8.36E-5
17 SGTC_1913 st060213 3.71 96.1 µM 5.43E-5 38 1.04E-4
18 SGTC_738 1315-0003 3.70 72.4 µM 5.59E-5 30 1.06E-4
19 SGTC_2279 7948423 3.65 32.9 µM 7.10E-5 19 1.33E-4
20 SGTC_1273 0849-0096 3.60 14.1 µM 8.45E-5 RPP1 & pyrimidine depletion 32 1.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.57E-13 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.125 4.10E-13 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.105 9.95E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.090 1.90E-7 YMR206W_p YMR206W_p hom Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication
0.089 2.41E-7 YNL038W GPI15 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.086 6.74E-7 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.083 1.49E-6 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.082 1.82E-6 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.080 3.40E-6 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
0.079 5.19E-6 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.074 1.60E-5 YBR074W_p YBR074W_p hom Putative metalloprotease
0.074 1.69E-5 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.074 1.86E-5 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.073 2.25E-5 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.069 5.90E-5 YJL047C RTT101 hom Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p