YIL112W / HOS4

Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL112W / HOS4

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.29|P-value:2.21E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.41|P-value:1.38E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.77|P-value:1.81E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:5.45|P-value:3.01E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:4.77|P-value:1.78E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:2.92|P-value:9.16E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.73|P-value:7.05E-21 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.91|P-value:1.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:3.59|P-value:6.43E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.96|P-value:7.70E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.22|P-value:3.23E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.68|P-value:3.46E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:3.62|P-value:5.51E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.25|P-value:2.63E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.18|P-value:3.48E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.23|P-value:2.77E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.29|P-value:8.33E-9 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.22|P-value:3.27E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.94|P-value:8.43E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.30|P-value:2.29E-6 ID:SGTC_2060|Compound:5238662|FD-Score:5.52|P-value:2.00E-9 ID:SGTC_2136|Compound:5328288|FD-Score:-3.65|P-value:5.47E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.81|P-value:2.33E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.04|P-value:5.84E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-2.96|P-value:8.55E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.47|P-value:9.38E-7 ID:SGTC_2334|Compound:9017922|FD-Score:3.81|P-value:2.34E-5 ID:SGTC_2425|Compound:5628681|FD-Score:-2.97|P-value:8.41E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.21|P-value:3.36E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.41|P-value:1.47E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.09|P-value:5.30E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.57|P-value:6.36E-7 ID:SGTC_2625|Compound:euphol|FD-Score:3.78|P-value:2.76E-5 ID:SGTC_2703|Compound:st077852|FD-Score:-2.98|P-value:7.82E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.43|P-value:1.26E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.80|P-value:2.48E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.25|P-value:2.56E-4 ID:SGTC_3044|Compound:9093193|FD-Score:2.98|P-value:7.38E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.02|P-value:6.29E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-2.98|P-value:7.99E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.35|P-value:1.71E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.29|P-value:2.21E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.29|P-value:2.17E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.41|P-value:1.38E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.77|P-value:1.81E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:5.45|P-value:3.01E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:4.77|P-value:1.78E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:2.92|P-value:9.16E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.73|P-value:7.05E-21 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.91|P-value:1.66E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:3.59|P-value:6.43E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.96|P-value:7.70E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.22|P-value:3.23E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.68|P-value:3.46E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:3.62|P-value:5.51E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.25|P-value:2.63E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.18|P-value:3.48E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.23|P-value:2.77E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.29|P-value:8.33E-9 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.22|P-value:3.27E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.94|P-value:8.43E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.30|P-value:2.29E-6 ID:SGTC_2060|Compound:5238662|FD-Score:5.52|P-value:2.00E-9 ID:SGTC_2136|Compound:5328288|FD-Score:-3.65|P-value:5.47E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.81|P-value:2.33E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.04|P-value:5.84E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-2.96|P-value:8.55E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.47|P-value:9.38E-7 ID:SGTC_2334|Compound:9017922|FD-Score:3.81|P-value:2.34E-5 ID:SGTC_2425|Compound:5628681|FD-Score:-2.97|P-value:8.41E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.21|P-value:3.36E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.41|P-value:1.47E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.09|P-value:5.30E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.57|P-value:6.36E-7 ID:SGTC_2625|Compound:euphol|FD-Score:3.78|P-value:2.76E-5 ID:SGTC_2703|Compound:st077852|FD-Score:-2.98|P-value:7.82E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.43|P-value:1.26E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.80|P-value:2.48E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.25|P-value:2.56E-4 ID:SGTC_3044|Compound:9093193|FD-Score:2.98|P-value:7.38E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.02|P-value:6.29E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-2.98|P-value:7.99E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.35|P-value:1.71E-4

Top fitness defect scores for YIL112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_178 4092-0806 8.73 87.5 µM 7.05E-21 ergosterol depletion effects on membrane 16 1.29E-18
2 SGTC_2060 5238662 5.52 140.0 µM 2.00E-9 10 1.71E-8
3 SGTC_137 0438-0332 5.45 85.4 µM 3.01E-9 ubiquinone biosynthesis & proteasome 68 2.46E-8
4 SGTC_852 0418-0143 5.29 439.0 µM 8.33E-9 calcium & mitochondrial duress 36 6.04E-8
5 SGTC_142 0335-0849 4.77 62.7 µM 1.78E-7 ubiquinone biosynthesis & proteasome 91 9.07E-7
6 SGTC_121 0557-0495 4.77 61.3 µM 1.81E-7 calcium & mitochondrial duress 33 9.22E-7
7 SGTC_2329 6138490 4.47 200.0 µM 9.38E-7 16 3.95E-6
8 SGTC_2004 4023728 4.30 41.9 µM 2.29E-6 20 8.71E-6
9 SGTC_2250 alverine citrate 3.81 130.0 µM 2.33E-5 167 6.81E-5
10 SGTC_2334 9017922 3.81 200.0 µM 2.34E-5 27 6.83E-5
11 SGTC_2908 7930301 3.80 100.0 µM 2.48E-5 30 7.19E-5
12 SGTC_2625 euphol 3.78 100.0 µM 2.76E-5 31 7.90E-5
13 SGTC_769 0302-0231 3.62 76.0 µM 5.51E-5 55 1.46E-4
14 SGTC_299 1273-0059 3.59 1.4 µM 6.43E-5 35 1.68E-4
15 SGTC_2781 5567276 3.43 71.4 µM 1.26E-4 80 3.05E-4
16 SGTC_120 rhodamine 6G 3.41 52.3 µM 1.38E-4 mitochondrial processes 55 3.31E-4
17 SGTC_3309 9129340 3.35 25.8 µM 1.71E-4 31 4.00E-4
18 SGTC_116 0155-0182 3.29 31.8 µM 2.17E-4 mitochondrial response to ROS 129 4.93E-4
19 SGTC_36 0335-0881 3.29 14.2 µM 2.21E-4 ubiquinone biosynthesis & proteasome 157 5.00E-4
20 SGTC_2937 9044753 3.25 11.3 µM 2.56E-4 60S ribosome export 62 5.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.231 8.74E-42 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.216 7.53E-37 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.216 1.39E-36 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.184 5.75E-27 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.183 9.58E-27 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.172 8.67E-24 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.163 1.66E-21 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.163 1.96E-21 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.161 5.81E-21 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.155 1.53E-19 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.152 8.03E-19 YPL126W NAN1 het U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
0.144 4.10E-17 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.144 6.56E-17 YOR048C RAT1 het Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
0.142 1.36E-16 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.137 1.42E-15 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis