YIL114C / POR2

Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL114C / POR2

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:-3.93|P-value:4.20E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.33|P-value:4.33E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.22|P-value:5.95E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.73|P-value:8.80E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.17|P-value:1.48E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.82|P-value:6.54E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.93|P-value:3.86E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.76|P-value:8.44E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.21|P-value:6.62E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.27|P-value:5.40E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.12|P-value:9.13E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.21|P-value:6.59E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.99|P-value:3.30E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.90|P-value:4.79E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.08|P-value:2.19E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.30|P-value:4.83E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.11|P-value:8.79E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.19|P-value:6.66E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-3.10|P-value:9.77E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.40|P-value:3.13E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.37|P-value:3.51E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.46|P-value:2.71E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.56|P-value:1.85E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.33|P-value:6.69E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.63|P-value:1.38E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-6.81|P-value:4.56E-12 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.49|P-value:3.54E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.93|P-value:3.92E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.28|P-value:4.82E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.99|P-value:3.00E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-4.36|P-value:6.39E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.93|P-value:4.20E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.33|P-value:4.33E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.22|P-value:5.95E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.73|P-value:8.80E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.17|P-value:1.48E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.82|P-value:6.54E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.93|P-value:3.86E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.76|P-value:8.44E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.21|P-value:6.62E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.27|P-value:5.40E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.12|P-value:9.13E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.21|P-value:6.59E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.99|P-value:3.30E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.90|P-value:4.79E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.08|P-value:2.19E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.30|P-value:4.83E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.11|P-value:8.79E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.19|P-value:6.66E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-3.10|P-value:9.77E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.40|P-value:3.13E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.37|P-value:3.51E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.46|P-value:2.71E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.56|P-value:1.85E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.33|P-value:6.69E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.63|P-value:1.38E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-6.81|P-value:4.56E-12 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.49|P-value:3.54E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.27|P-value:5.09E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.93|P-value:3.92E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.28|P-value:4.82E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.99|P-value:3.00E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-4.36|P-value:6.39E-6

Top fitness defect scores for YIL114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2337 9009472 4.33 200.0 µM 6.69E-6 22 7.33E-6
2 SGTC_2828 7998861 3.99 71.4 µM 3.00E-5 16 3.25E-5
3 SGTC_417 st075190 3.93 100.0 µM 3.86E-5 9 4.18E-5
4 SGTC_2819 7996655 3.93 46.4 µM 3.92E-5 22 4.24E-5
5 SGTC_340 k038-0059 3.73 454.0 µM 8.80E-5 ubiquinone biosynthesis & proteasome 52 9.46E-5
6 SGTC_1958 st076513 3.40 41.9 µM 3.13E-4 60S ribosome export 53 3.34E-4
7 SGTC_1966 st070145 3.37 16.1 µM 3.51E-4 43 3.73E-4
8 SGTC_1351 1496-0003 3.31 46.5 µM 4.43E-4 36 4.70E-4
9 SGTC_2820 7989630 3.28 71.4 µM 4.82E-4 ERG2 41 5.12E-4
10 SGTC_2751 anetholtrithion 3.27 17.2 µM 5.09E-4 52 5.40E-4
11 SGTC_335 4077-0256 3.22 27.6 µM 5.95E-4 34 6.30E-4
12 SGTC_1709 st033179 3.19 39.1 µM 6.66E-4 41 7.06E-4
13 SGTC_1705 st027868 3.11 56.3 µM 8.79E-4 35 9.30E-4
14 SGTC_142 0335-0849 3.07 62.7 µM 0.00102 ubiquinone biosynthesis & proteasome 194 0.00108
15 SGTC_1668 st014914 3.05 51.6 µM 0.00108 RPP1 & pyrimidine depletion 27 0.00114
16 SGTC_561 1550-0330 3.05 72.9 µM 0.00109 40 0.00115
17 SGTC_3202 9113761 3.05 49.5 µM 0.00109 98 0.00115
18 SGTC_1689 st020265 3.05 53.5 µM 0.00109 41 0.00115
19 SGTC_1625 st003711 2.99 30.1 µM 0.00130 calcium & mitochondrial duress 84 0.00138
20 SGTC_2787 5284540 2.97 71.4 µM 0.00142 74 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.95E-11 YEL015W EDC3 hom Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
0.100 7.00E-9 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.099 7.85E-9 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.097 1.66E-8 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.094 4.60E-8 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.092 9.33E-8 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.089 2.60E-7 YLR008C PAM18 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
0.087 4.06E-7 YMR028W TAP42 het Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.086 6.71E-7 YKL097C_d YKL097C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.085 9.63E-7 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.084 9.68E-7 YNL325C FIG4 hom Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain
0.084 1.20E-6 YHR106W TRR2 hom Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.082 1.97E-6 YLR267W_p BOP2_p hom Protein of unknown function
0.082 2.03E-6 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.080 3.04E-6 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress