HIPHOP chemogenomics database

YIL115C / NUP159

FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)

Zygosity: Heterozygous strain

fixedexpanded
Profile for YIL115C / NUP159

Click on Significant Values for Screen Details

Top fitness defect scores for YIL115C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_766	1391-0721	12.80	126.0 µM	1.39E-38		1	4.97E-38	8.31
2	SGTC_2973	9094665	9.25	18.0 µM	5.25E-21	NEO1	3	1.11E-20	0.79
3	SGTC_768	0384-0033	6.68	77.3 µM	7.52E-12	fatty acid desaturase (OLE1)	7	1.19E-11	0.29
4	SGTC_62	0180-0423	5.67	3.2 µM	4.99E-9	60S ribosome export	4	7.15E-9	0.80
5	SGTC_3101	9120531	5.53	49.5 µM	1.16E-8		3	1.64E-8	0.61
6	SGTC_2968	9090663	5.29	33.4 µM	4.45E-8		6	6.17E-8	0.11
7	SGTC_1203	3992-3522	4.91	103.0 µM	3.36E-7		7	4.51E-7	0.29
8	SGTC_915	methyl methanesulfonate (MMS)	4.75	110.0 mM	7.80E-7	DNA damage response	6	1.03E-6	0.05
9	SGTC_2450	5739737	4.70	12.9 µM	9.82E-7		2	1.30E-6	0.50
10	SGTC_2971	9092186	4.67	9.9 µM	1.16E-6	ergosterol biosynthesis	7	1.53E-6	0.21
11	SGTC_883	0850-0245	4.61	24.6 µM	1.54E-6	cell wall	3	2.02E-6	0.22
12	SGTC_2607	solasodine	4.54	47.4 µM	2.17E-6		8	2.82E-6	0.07
13	SGTC_2726	cimetidine	4.41	79.3 µM	3.97E-6		2	5.12E-6	0.63
14	SGTC_55	0767-0285	4.38	6.6 µM	4.50E-6		5	5.80E-6	0.20
15	SGTC_635	k038-0028	4.35	24.7 µM	5.33E-6	ubiquinone biosynthesis & proteasome	12	6.84E-6	0.04
16	SGTC_518	1021-0119	4.20	62.6 µM	1.05E-5	ERG2	6	1.34E-5	0.10
17	SGTC_1529	apigenin	4.13	74.0 µM	1.44E-5		4	1.81E-5	0.19
18	SGTC_1510	1123-0200	4.04	71.5 µM	2.14E-5		15	2.69E-5	0.07
19	SGTC_2389	9091542	3.96	195.5 µM	2.95E-5	iron homeostasis	6	3.68E-5	0.20
20	SGTC_2586	curcumin	3.89	80.0 µM	3.96E-5	iron homeostasis	10	4.92E-5	0.02

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.298	5.28E-70	YER066W_p	RRT13_p	hom	Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.274	5.06E-59	YLR395C	COX8	hom	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.251	3.56E-49	YGL146C_p	RRT6_p	hom	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.220	4.47E-38	YGR015C_p	YGR015C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.195	5.24E-30	YJL043W_p	YJL043W_p	hom	Putative protein of unknown function; YJL043W is a non-essential gene
0.190	1.71E-28	YOR300W_d	YOR300W_d	hom	Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.186	1.25E-27	YCR102W-A_d	YCR102W-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.176	1.15E-24	YEL049W	PAU2	hom	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.176	1.21E-24	YNR067C	DSE4	hom	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.169	5.16E-23	YGL144C	ROG1	hom	Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.169	8.61E-23	YNL220W	ADE12	hom	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.168	1.48E-22	YER068W	MOT2	hom	Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.158	3.52E-20	YPL100W	ATG21	hom	Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.149	3.93E-18	YER071C_p	TDA2_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.145	2.47E-17	YHR194W	MDM31	hom	Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34