YIL117C / PRM5

Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL117C / PRM5

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.35|P-value:2.18E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:4.70|P-value:4.29E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.62|P-value:7.27E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:-5.49|P-value:6.64E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.16|P-value:5.59E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:8.32|P-value:1.88E-18 ID:SGTC_157|Compound:1348-1695|FD-Score:4.07|P-value:1.00E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.25|P-value:3.99E-4 ID:SGTC_271|Compound:rotenone|FD-Score:5.78|P-value:7.51E-10 ID:SGTC_559|Compound:1550-0661|FD-Score:3.12|P-value:5.22E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.47|P-value:1.40E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.24|P-value:3.37E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.13|P-value:5.10E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.22|P-value:3.63E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.46|P-value:1.75E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.13|P-value:5.19E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.72|P-value:3.85E-7 ID:SGTC_1081|Compound:sertraline|FD-Score:3.25|P-value:3.27E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.41|P-value:1.92E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.09|P-value:1.16E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.54|P-value:1.04E-6 ID:SGTC_1719|Compound:st032227|FD-Score:-3.20|P-value:4.74E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.58|P-value:8.89E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:2.47E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.95|P-value:9.74E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.66|P-value:6.32E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.35|P-value:2.20E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.65|P-value:6.60E-5 ID:SGTC_2127|Compound:5253358|FD-Score:8.32|P-value:1.92E-18 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.53|P-value:3.61E-9 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.15|P-value:4.83E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.20|P-value:4.74E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.12|P-value:5.25E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.06|P-value:6.62E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.41|P-value:1.72E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.14|P-value:7.25E-6 ID:SGTC_2380|Compound:9035439|FD-Score:4.81|P-value:2.47E-7 ID:SGTC_2393|Compound:9031399|FD-Score:-3.92|P-value:2.51E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-4.95|P-value:1.48E-7 ID:SGTC_2395|Compound:5646831|FD-Score:-4.41|P-value:2.53E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.33|P-value:3.73E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.09|P-value:9.36E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.98|P-value:8.87E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.30|P-value:2.67E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.88|P-value:2.41E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.15|P-value:5.71E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.32|P-value:3.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.77|P-value:3.86E-7 ID:SGTC_3145|Compound:9085516|FD-Score:-4.33|P-value:3.72E-6 ID:SGTC_3214|Compound:9129694|FD-Score:3.21|P-value:3.83E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.35|P-value:2.18E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:4.70|P-value:4.29E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.62|P-value:7.27E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:-5.49|P-value:6.64E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.16|P-value:5.59E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:8.32|P-value:1.88E-18 ID:SGTC_157|Compound:1348-1695|FD-Score:4.07|P-value:1.00E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.25|P-value:3.99E-4 ID:SGTC_271|Compound:rotenone|FD-Score:5.78|P-value:7.51E-10 ID:SGTC_559|Compound:1550-0661|FD-Score:3.12|P-value:5.22E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.47|P-value:1.40E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.24|P-value:3.37E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.13|P-value:5.10E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.22|P-value:3.63E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.46|P-value:1.75E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.13|P-value:5.19E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.72|P-value:3.85E-7 ID:SGTC_1081|Compound:sertraline|FD-Score:3.25|P-value:3.27E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.41|P-value:1.92E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.09|P-value:1.16E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.54|P-value:1.04E-6 ID:SGTC_1719|Compound:st032227|FD-Score:-3.20|P-value:4.74E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.58|P-value:8.89E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:2.47E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.95|P-value:9.74E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.66|P-value:6.32E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.35|P-value:2.20E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.65|P-value:6.60E-5 ID:SGTC_2127|Compound:5253358|FD-Score:8.32|P-value:1.92E-18 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.53|P-value:3.61E-9 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.15|P-value:4.83E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.20|P-value:4.74E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.12|P-value:5.25E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.06|P-value:6.62E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.41|P-value:1.72E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.14|P-value:7.25E-6 ID:SGTC_2380|Compound:9035439|FD-Score:4.81|P-value:2.47E-7 ID:SGTC_2393|Compound:9031399|FD-Score:-3.92|P-value:2.51E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-4.95|P-value:1.48E-7 ID:SGTC_2395|Compound:5646831|FD-Score:-4.41|P-value:2.53E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.33|P-value:3.73E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.09|P-value:9.36E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.98|P-value:8.87E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.30|P-value:2.67E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.88|P-value:2.41E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.15|P-value:5.71E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-3.32|P-value:3.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.77|P-value:3.86E-7 ID:SGTC_3145|Compound:9085516|FD-Score:-4.33|P-value:3.72E-6 ID:SGTC_3214|Compound:9129694|FD-Score:3.21|P-value:3.83E-4

Top fitness defect scores for YIL117C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_153 4077-0274 8.32 519.7 µM 1.88E-18 1 4.36E-17
2 SGTC_2127 5253358 8.32 187.9 µM 1.92E-18 2 4.43E-17
3 SGTC_271 rotenone 5.78 740.0 µM 7.51E-10 4 3.68E-9
4 SGTC_2129 girgensonine 5.53 121.0 µM 3.61E-9 heme biosynthesis & mitochondrial translocase 14 1.56E-8
5 SGTC_2380 9035439 4.81 200.0 µM 2.47E-7 endomembrane recycling 5 7.67E-7
6 SGTC_1001 4048-4355 4.72 44.4 µM 3.85E-7 copper-dependent oxidative stress 21 1.15E-6
7 SGTC_24 0417-1663 4.70 219.0 µM 4.29E-7 9 1.28E-6
8 SGTC_1370 2001-0092 4.54 44.6 µM 1.04E-6 16 2.88E-6
9 SGTC_1126 isoteolin 4.41 1.0 µM 1.92E-6 20 5.07E-6
10 SGTC_2318 6029776 4.14 164.0 µM 7.25E-6 24 1.73E-5
11 SGTC_2426 5582046 4.09 32.2 µM 9.36E-6 25 2.18E-5
12 SGTC_157 1348-1695 4.07 65.8 µM 1.00E-5 iron homeostasis 65 2.33E-5
13 SGTC_2582 agaric acid 3.88 100.0 µM 2.41E-5 redox potentiating 324 5.23E-5
14 SGTC_1808 st050063 3.66 61.5 µM 6.32E-5 17 1.27E-4
15 SGTC_2063 5246145 3.65 200.0 µM 6.60E-5 30 1.32E-4
16 SGTC_142 0335-0849 3.62 62.7 µM 7.27E-5 ubiquinone biosynthesis & proteasome 146 1.45E-4
17 SGTC_1741 st038134 3.58 10.2 µM 8.89E-5 39 1.74E-4
18 SGTC_571 k831-0106 3.47 44.2 µM 1.40E-4 23 2.64E-4
19 SGTC_2263 7948595 3.41 193.3 µM 1.72E-4 17 3.19E-4
20 SGTC_20 0481-0013 3.35 4.9 µM 2.18E-4 46 3.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.46E-13 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
0.111 1.09E-10 YIL084C SDS3 hom Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
0.109 2.47E-10 YPL098C MGR2 hom Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)
0.108 3.14E-10 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.105 9.69E-10 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.098 1.35E-8 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.098 1.34E-8 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.55E-8 YOR320C GNT1 hom N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
0.095 3.32E-8 YMR009W ADI1 hom Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
0.093 7.05E-8 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.087 4.87E-7 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.087 5.10E-7 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.085 9.06E-7 YOR324C FRT1 hom Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication
0.083 1.28E-6 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.083 1.61E-6 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3