YIL129C / TAO3

Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL129C / TAO3

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:2.96|P-value:6.78E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.26|P-value:3.10E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.02|P-value:7.36E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.23|P-value:2.40E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.02|P-value:7.54E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.86|P-value:2.44E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.40|P-value:1.19E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.28|P-value:1.92E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.77|P-value:3.90E-17 ID:SGTC_266|Compound:formosanin C|FD-Score:4.40|P-value:1.09E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.95|P-value:1.02E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.34|P-value:2.39E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.50|P-value:7.92E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.62|P-value:7.75E-10 ID:SGTC_662|Compound:k832-1615|FD-Score:3.66|P-value:3.88E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.95|P-value:1.58E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.44|P-value:9.97E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.52|P-value:5.63E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.39|P-value:1.25E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.51|P-value:7.45E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.35|P-value:1.47E-4 ID:SGTC_1644|Compound:st010134|FD-Score:2.88|P-value:9.20E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.67|P-value:3.73E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.72|P-value:1.90E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-3.65|P-value:6.08E-5 ID:SGTC_1870|Compound:st057514|FD-Score:-3.09|P-value:5.90E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.45|P-value:9.50E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.97|P-value:9.45E-6 ID:SGTC_2096|Compound:5468907|FD-Score:3.24|P-value:2.26E-4 ID:SGTC_2098|Compound:5376439|FD-Score:-4.15|P-value:6.18E-6 ID:SGTC_2266|Compound:7929956|FD-Score:-4.47|P-value:1.21E-6 ID:SGTC_2269|Compound:7935389|FD-Score:4.21|P-value:2.85E-6 ID:SGTC_2275|Compound:7947463|FD-Score:6.99|P-value:3.15E-14 ID:SGTC_2278|Compound:7948257|FD-Score:3.56|P-value:6.12E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.62|P-value:7.01E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-3.07|P-value:6.42E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.92|P-value:5.87E-8 ID:SGTC_2439|Compound:5492030|FD-Score:4.02|P-value:7.19E-6 ID:SGTC_2483|Compound:5729050|FD-Score:2.89|P-value:8.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.50|P-value:4.90E-62 ID:SGTC_2584|Compound:androsterone|FD-Score:2.89|P-value:8.64E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-6.16|P-value:3.63E-11 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.99|P-value:6.13E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.04|P-value:4.94E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.24|P-value:8.57E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.33|P-value:1.51E-6 ID:SGTC_2967|Compound:9089538|FD-Score:4.01|P-value:7.65E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-2.96|P-value:9.54E-4 ID:SGTC_3215|Compound:9129942|FD-Score:5.69|P-value:4.77E-10 ID:SGTC_3221|Compound:9128209|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:2.96|P-value:6.78E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.26|P-value:3.10E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.02|P-value:7.36E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.23|P-value:2.40E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.02|P-value:7.54E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.86|P-value:2.44E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.40|P-value:1.19E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.28|P-value:1.92E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.77|P-value:3.90E-17 ID:SGTC_266|Compound:formosanin C|FD-Score:4.40|P-value:1.09E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.95|P-value:1.02E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-4.34|P-value:2.39E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.50|P-value:7.92E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.62|P-value:7.75E-10 ID:SGTC_662|Compound:k832-1615|FD-Score:3.66|P-value:3.88E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.95|P-value:1.58E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.44|P-value:9.97E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.52|P-value:5.63E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.39|P-value:1.25E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.51|P-value:7.45E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.35|P-value:1.47E-4 ID:SGTC_1644|Compound:st010134|FD-Score:2.88|P-value:9.20E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.67|P-value:3.73E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.72|P-value:1.90E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-3.65|P-value:6.08E-5 ID:SGTC_1870|Compound:st057514|FD-Score:-3.09|P-value:5.90E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.45|P-value:9.50E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.97|P-value:9.45E-6 ID:SGTC_2096|Compound:5468907|FD-Score:3.24|P-value:2.26E-4 ID:SGTC_2098|Compound:5376439|FD-Score:-4.15|P-value:6.18E-6 ID:SGTC_2266|Compound:7929956|FD-Score:-4.47|P-value:1.21E-6 ID:SGTC_2269|Compound:7935389|FD-Score:4.21|P-value:2.85E-6 ID:SGTC_2275|Compound:7947463|FD-Score:6.99|P-value:3.15E-14 ID:SGTC_2278|Compound:7948257|FD-Score:3.56|P-value:6.12E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.62|P-value:7.01E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-3.07|P-value:6.42E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.92|P-value:5.87E-8 ID:SGTC_2439|Compound:5492030|FD-Score:4.02|P-value:7.19E-6 ID:SGTC_2483|Compound:5729050|FD-Score:2.89|P-value:8.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.50|P-value:4.90E-62 ID:SGTC_2584|Compound:androsterone|FD-Score:2.89|P-value:8.64E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-6.16|P-value:3.63E-11 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.99|P-value:6.13E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.04|P-value:4.94E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.24|P-value:8.57E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.33|P-value:1.51E-6 ID:SGTC_2967|Compound:9089538|FD-Score:4.01|P-value:7.65E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-2.96|P-value:9.54E-4 ID:SGTC_3215|Compound:9129942|FD-Score:5.69|P-value:4.77E-10 ID:SGTC_3221|Compound:9128209|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.43|P-value:1.06E-4

Top fitness defect scores for YIL129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2582 agaric acid 15.50 100.0 µM 4.90E-62 redox potentiating 1 1.57E-54 2.23
2 SGTC_163 1327-0036 7.77 7.5 µM 3.90E-17 22 3.88E-15 0.19
3 SGTC_2275 7947463 6.99 200.0 µM 3.15E-14 iron homeostasis 1 1.37E-12 0.97
4 SGTC_3215 9129942 5.69 49.5 µM 4.77E-10 1 6.30E-9 0.85
5 SGTC_435 c-PAF 5.62 6.7 µM 7.75E-10 9 9.64E-9 0.40
6 SGTC_2651 1327-0036 5.24 5.0 µM 8.57E-9 37 7.91E-8 0.08
7 SGTC_2412 st077135 4.92 33.4 µM 5.87E-8 4 4.27E-7 0.62
8 SGTC_1680 diphenhydramine 4.72 100.0 µM 1.90E-7 NEO1 9 1.20E-6 0.13
9 SGTC_1132 3456-3614 4.52 2.5 µM 5.63E-7 tubulin folding & SWR complex 7 3.09E-6 0.02
10 SGTC_266 formosanin C 4.40 406.0 nM 1.09E-6 sphingolipid biosynthesis & PDR1 20 5.51E-6 0.04
11 SGTC_2688 kanamycin b 4.33 96.7 µM 1.51E-6 calcium & mitochondrial duress 16 7.33E-6 0.10
12 SGTC_2269 7935389 4.21 174.4 µM 2.85E-6 tubulin folding & SWR complex 5 1.28E-5 0.05
13 SGTC_2439 5492030 4.02 7.2 µM 7.19E-6 5 2.88E-5 0.09
14 SGTC_124 0136-0217 4.02 7.1 µM 7.36E-6 mitochondrial stress 23 2.94E-5 0.02
15 SGTC_2967 9089538 4.01 49.9 µM 7.65E-6 14 3.04E-5 0.11
16 SGTC_2017 5132927 3.97 60.6 µM 9.45E-6 5 3.66E-5 0.20
17 SGTC_309 k408-0051 3.95 1.5 µM 1.02E-5 23 3.90E-5 0.04
18 SGTC_1678 st019265 3.67 80.2 µM 3.73E-5 60S ribosome export 7 1.22E-4 0.07
19 SGTC_662 k832-1615 3.66 104.0 µM 3.88E-5 7 1.26E-4 0.19
20 SGTC_2278 7948257 3.56 134.3 µM 6.12E-5 4 1.88E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.435 5.65E-155 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.372 1.34E-110 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.355 1.88E-100 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.347 8.48E-96 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.340 1.69E-91 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.339 8.86E-91 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.322 6.99E-82 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.321 2.24E-81 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.312 7.55E-77 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.298 8.87E-70 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.296 1.29E-68 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.286 1.95E-64 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.286 3.71E-64 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.259 1.96E-52 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.258 4.79E-52 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization