YIL130W / ASG1

Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL130W / ASG1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.21|P-value:6.14E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:3.00|P-value:9.29E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.30|P-value:3.08E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.21|P-value:6.17E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:5.41|P-value:9.37E-9 ID:SGTC_523|Compound:1934-0222|FD-Score:3.06|P-value:7.37E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.04|P-value:1.35E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.40|P-value:1.92E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.23|P-value:3.93E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.04|P-value:7.92E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.15|P-value:5.34E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.61|P-value:8.23E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:3.48|P-value:1.50E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.23|P-value:3.96E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.36|P-value:2.43E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.44|P-value:1.78E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-3.25|P-value:3.54E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.54|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.93|P-value:2.20E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.27|P-value:4.53E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.10|P-value:6.40E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.03|P-value:7.96E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.22|P-value:4.12E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.64|P-value:7.63E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.12|P-value:5.93E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.32|P-value:2.77E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.03|P-value:8.22E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-4.05|P-value:1.18E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.24|P-value:3.81E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.01|P-value:8.26E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.41|P-value:2.00E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.03|P-value:8.12E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.07|P-value:7.23E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.19|P-value:4.61E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.13|P-value:5.78E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.05|P-value:7.31E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.00|P-value:9.29E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.25|P-value:3.46E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.42|P-value:1.19E-11 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.46|P-value:1.65E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.84|P-value:3.28E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-6.19|P-value:5.63E-11 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.78|P-value:9.31E-10 ID:SGTC_2703|Compound:st077852|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.33|P-value:2.74E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.15|P-value:5.33E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.63|P-value:7.50E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.00|P-value:9.11E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.39|P-value:1.98E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.00|P-value:8.82E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.81|P-value:2.80E-7 ID:SGTC_3072|Compound:9116419|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.21|P-value:4.30E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.25|P-value:3.66E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.35|P-value:3.04E-6 ID:SGTC_3216|Compound:9129716|FD-Score:3.41|P-value:2.02E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.21|P-value:6.14E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:3.00|P-value:9.29E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.30|P-value:3.08E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.21|P-value:6.17E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:5.41|P-value:9.37E-9 ID:SGTC_523|Compound:1934-0222|FD-Score:3.06|P-value:7.37E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.04|P-value:1.35E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.40|P-value:1.92E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.23|P-value:3.93E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.04|P-value:7.92E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.15|P-value:5.34E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.61|P-value:8.23E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:3.48|P-value:1.50E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.23|P-value:3.96E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.36|P-value:2.43E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.44|P-value:1.78E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-3.25|P-value:3.54E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.54|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.93|P-value:2.20E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.27|P-value:4.53E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.10|P-value:6.40E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.03|P-value:7.96E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.22|P-value:4.12E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.64|P-value:7.63E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.12|P-value:5.93E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.32|P-value:2.77E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.03|P-value:8.22E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-4.05|P-value:1.18E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.24|P-value:3.81E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.01|P-value:8.26E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.41|P-value:2.00E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.03|P-value:8.12E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.07|P-value:7.23E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.19|P-value:4.61E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.13|P-value:5.78E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.05|P-value:7.31E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.00|P-value:9.29E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.25|P-value:3.46E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.42|P-value:1.19E-11 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.46|P-value:1.65E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.84|P-value:3.28E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-6.19|P-value:5.63E-11 ID:SGTC_2628|Compound:lathosterol|FD-Score:5.78|P-value:9.31E-10 ID:SGTC_2703|Compound:st077852|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.33|P-value:2.74E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.15|P-value:5.33E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.63|P-value:7.50E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.00|P-value:9.11E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.39|P-value:1.98E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.00|P-value:8.82E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.81|P-value:2.80E-7 ID:SGTC_3072|Compound:9116419|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.21|P-value:4.30E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.25|P-value:3.66E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.35|P-value:3.04E-6 ID:SGTC_3216|Compound:9129716|FD-Score:3.41|P-value:2.02E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.51|P-value:1.34E-4

Top fitness defect scores for YIL130W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 6.42 100.0 µM 1.19E-11 8 6.64E-11
2 SGTC_2628 lathosterol 5.78 100.0 µM 9.31E-10 7 3.76E-9
3 SGTC_379 3970-0972 5.41 5.9 µM 9.37E-9 tubulin folding & SWR complex 7 3.18E-8
4 SGTC_2973 9094665 4.81 18.0 µM 2.80E-7 NEO1 16 7.41E-7
5 SGTC_3166 9102297 4.35 49.5 µM 3.04E-6 Golgi 26 6.74E-6
6 SGTC_1178 0988-0033 4.27 191.0 µM 4.53E-6 21 9.76E-6
7 SGTC_18 0111-0177 4.21 500.0 nM 6.14E-6 59 1.29E-5
8 SGTC_378 3970-0959 4.21 8.3 µM 6.17E-6 14 1.30E-5
9 SGTC_577 r071-0003 4.04 38.6 µM 1.35E-5 fatty acid desaturase (OLE1) 50 2.70E-5
10 SGTC_1107 amlodipine 3.93 47.0 µM 2.20E-5 33 4.22E-5
11 SGTC_2623 humulene 3.84 100.0 µM 3.28E-5 21 6.13E-5
12 SGTC_1616 st002734 3.64 56.1 µM 7.63E-5 37 1.34E-4
13 SGTC_1103 duloxetine 3.54 36.1 µM 1.18E-4 48 2.01E-4
14 SGTC_2703 st077852 3.52 53.4 µM 1.26E-4 37 2.14E-4
15 SGTC_3252 9135871 3.51 49.5 µM 1.34E-4 22 2.27E-4
16 SGTC_946 3434-1334 3.48 87.4 µM 1.50E-4 46 2.51E-4
17 SGTC_2443 5493264 3.47 126.7 µM 1.53E-4 35 2.57E-4
18 SGTC_2616 abietic acid 3.46 100.0 µM 1.65E-4 46 2.75E-4
19 SGTC_3238 9133470 3.44 49.5 µM 1.73E-4 23 2.87E-4
20 SGTC_1101 ebselen 3.44 5.3 µM 1.78E-4 40 2.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 9.43E-16 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
0.100 6.73E-9 YOR369C RPS12 hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog
0.095 3.27E-8 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.092 9.25E-8 YBR008C FLR1 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress
0.092 9.35E-8 YHR014W SPO13 hom Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
0.090 1.92E-7 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.087 5.07E-7 YKR092C SRP40 hom Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
0.083 1.30E-6 YMR285C NGL2 hom Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.082 2.03E-6 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.080 3.69E-6 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.080 3.75E-6 YNL222W SSU72 het Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
0.079 5.12E-6 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.077 8.55E-6 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.077 8.72E-6 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.075 1.45E-5 YPL026C SKS1 hom Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway