YIL139C / REV7

Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL139C / REV7

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-4.43|P-value:3.81E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.96|P-value:3.12E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:6.79|P-value:1.80E-12 ID:SGTC_334|Compound:1502-1024|FD-Score:3.09|P-value:7.33E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.98|P-value:1.58E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.37|P-value:2.61E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.93|P-value:2.68E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.11|P-value:8.48E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.17|P-value:5.40E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.88|P-value:3.34E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.26|P-value:5.04E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-4.91|P-value:3.32E-7 ID:SGTC_1704|Compound:st028805|FD-Score:3.24|P-value:4.24E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.97|P-value:2.24E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.42|P-value:2.13E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.61|P-value:1.09E-6 ID:SGTC_1915|Compound:st067105|FD-Score:3.74|P-value:5.90E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:4.35|P-value:3.96E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.25|P-value:4.10E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.42|P-value:2.14E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.04|P-value:8.76E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.93|P-value:2.66E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.32|P-value:3.09E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.24|P-value:5.39E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.59|P-value:1.12E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.35|P-value:3.90E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.69|P-value:7.17E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.85|P-value:3.77E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.59|P-value:1.11E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.35|P-value:2.76E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.57|P-value:1.19E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.69|P-value:9.79E-5 ID:SGTC_3093|Compound:9117344|FD-Score:-3.15|P-value:7.61E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-5.12|P-value:1.07E-7 ID:SGTC_3295|Compound:9122362|FD-Score:3.24|P-value:4.16E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.07|P-value:0.00100 ID:SGTC_3320|Compound:9137005|FD-Score:3.30|P-value:3.36E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.67|P-value:1.06E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-4.43|P-value:3.81E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.96|P-value:3.12E-5 ID:SGTC_247|Compound:mechlorethamine|FD-Score:6.79|P-value:1.80E-12 ID:SGTC_334|Compound:1502-1024|FD-Score:3.09|P-value:7.33E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.98|P-value:1.58E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.37|P-value:2.61E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.93|P-value:2.68E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.11|P-value:8.48E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.17|P-value:5.40E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.88|P-value:3.34E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.26|P-value:5.04E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-4.91|P-value:3.32E-7 ID:SGTC_1704|Compound:st028805|FD-Score:3.24|P-value:4.24E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.97|P-value:2.24E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.42|P-value:2.13E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.61|P-value:1.09E-6 ID:SGTC_1915|Compound:st067105|FD-Score:3.74|P-value:5.90E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:4.35|P-value:3.96E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.25|P-value:4.10E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.42|P-value:2.14E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.04|P-value:8.76E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.93|P-value:2.66E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.32|P-value:3.09E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.24|P-value:5.39E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.59|P-value:1.12E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.35|P-value:3.90E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.69|P-value:7.17E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.85|P-value:3.77E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.59|P-value:1.11E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.35|P-value:2.76E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.57|P-value:1.19E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.69|P-value:9.79E-5 ID:SGTC_3093|Compound:9117344|FD-Score:-3.15|P-value:7.61E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-5.12|P-value:1.07E-7 ID:SGTC_3295|Compound:9122362|FD-Score:3.24|P-value:4.16E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.07|P-value:0.00100 ID:SGTC_3320|Compound:9137005|FD-Score:3.30|P-value:3.36E-4

Top fitness defect scores for YIL139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_247 mechlorethamine 6.79 29.7 µM 1.80E-12 DNA damage response 4 5.75E-12
2 SGTC_534 k292-0788 4.98 63.4 µM 1.58E-7 mitochondrial processes 7 3.13E-7
3 SGTC_2765 myclobutanil 4.69 7.7 µM 7.17E-7 azole & statin 29 1.34E-6
4 SGTC_1895 st058434 4.61 18.3 µM 1.09E-6 9 1.99E-6
5 SGTC_2753 fluvastatin 4.35 17.1 µM 3.90E-6 azole & statin 23 6.76E-6
6 SGTC_1955 wogonin 4.35 32.4 µM 3.96E-6 13 6.86E-6
7 SGTC_1758 st042942 3.97 75.2 µM 2.24E-5 20 3.61E-5
8 SGTC_2069 5228469 3.93 200.0 µM 2.66E-5 12 4.24E-5
9 SGTC_780 0109-0199 3.93 192.0 µM 2.68E-5 14 4.27E-5
10 SGTC_1250 0485-0349 3.88 40.2 µM 3.34E-5 38 5.28E-5
11 SGTC_2766 oltipraz 3.85 83.9 µM 3.77E-5 heme requiring 27 5.92E-5
12 SGTC_1915 st067105 3.74 30.6 µM 5.90E-5 RNA pol III & RNase P/MRP 53 9.10E-5
13 SGTC_2066 5222451 3.61 176.0 µM 1.03E-4 heme biosynthesis & mitochondrial translocase 43 1.54E-4
14 SGTC_2768 sulfasalazine 3.59 50.2 µM 1.11E-4 26 1.66E-4
15 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.59 100.0 µM 1.12E-4 48 1.68E-4
16 SGTC_3001 9076041 3.57 71.4 µM 1.19E-4 21 1.78E-4
17 SGTC_135 0933-0004 3.51 26.4 µM 1.51E-4 60S ribosome export 37 2.24E-4
18 SGTC_1886 st057356 3.42 49.9 µM 2.13E-4 60S ribosome export 33 3.11E-4
19 SGTC_2042 p-Dimethylaminoacetophenone 3.42 200.0 µM 2.14E-4 40 3.13E-4
20 SGTC_626 0214-0009 3.37 33.0 µM 2.61E-4 copper-dependent oxidative stress 38 3.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.26E-12 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.096 2.20E-8 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.090 1.94E-7 YBL076C ILS1 het Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
0.089 2.26E-7 YLR118C YLR118C hom Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
0.088 3.17E-7 YOR339C UBC11 hom Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
0.086 5.96E-7 YMR018W_p YMR018W_p hom Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
0.085 7.32E-7 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.085 7.59E-7 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.084 9.71E-7 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.083 1.34E-6 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.080 3.29E-6 YBR113W_d YBR113W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
0.080 3.37E-6 YLR095C IOC2 hom Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
0.080 3.52E-6 YER039C-A_p YER039C-A_p hom Putative protein of unknown function; YER039C-A is not an essential gene
0.080 3.94E-6 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.078 5.83E-6 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus