YIL145C / PAN6

Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL145C / PAN6

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-4.27|P-value:2.33E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:2.64|P-value:9.53E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:2.87|P-value:3.61E-4 ID:SGTC_499|Compound:genistein|FD-Score:3.05|P-value:1.69E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.02|P-value:1.89E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.85|P-value:3.99E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.78|P-value:5.18E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.06|P-value:1.33E-9 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.72|P-value:5.97E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.72|P-value:5.92E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.74|P-value:6.43E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.86|P-value:3.92E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.36|P-value:3.92E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:2.91|P-value:3.09E-4 ID:SGTC_1956|Compound:st077085|FD-Score:2.70|P-value:7.63E-4 ID:SGTC_2223|Compound:6903751|FD-Score:2.63|P-value:0.00100 ID:SGTC_2288|Compound:7946289|FD-Score:2.86|P-value:3.92E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-2.81|P-value:4.53E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.76|P-value:5.91E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.14|P-value:1.13E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.77|P-value:5.45E-4 ID:SGTC_2805|Compound:7950783|FD-Score:2.71|P-value:7.06E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.67|P-value:8.17E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.26|P-value:6.19E-5 ID:SGTC_3069|Compound:9117009|FD-Score:3.00|P-value:2.11E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.52|P-value:1.71E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.40|P-value:2.98E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-3.36|P-value:3.69E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.48|P-value:2.08E-5 ID:SGTC_3155|Compound:9099265|FD-Score:2.67|P-value:8.37E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.34|P-value:4.08E-5 ID:SGTC_3236|Compound:9132701|FD-Score:3.41|P-value:2.98E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.80|P-value:3.90E-6 ID:SGTC_3302|Compound:9125395|FD-Score:3.00|P-value:2.13E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-4.27|P-value:2.33E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:2.64|P-value:9.53E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:2.87|P-value:3.61E-4 ID:SGTC_499|Compound:genistein|FD-Score:3.05|P-value:1.69E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.02|P-value:1.89E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.85|P-value:3.99E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.78|P-value:5.18E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.06|P-value:1.33E-9 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.72|P-value:5.97E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.72|P-value:5.92E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.74|P-value:6.43E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:2.86|P-value:3.92E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.36|P-value:3.92E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:2.91|P-value:3.09E-4 ID:SGTC_1956|Compound:st077085|FD-Score:2.70|P-value:7.63E-4 ID:SGTC_2223|Compound:6903751|FD-Score:2.63|P-value:0.00100 ID:SGTC_2288|Compound:7946289|FD-Score:2.86|P-value:3.92E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-2.81|P-value:4.53E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.76|P-value:5.91E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.14|P-value:1.13E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.77|P-value:5.45E-4 ID:SGTC_2805|Compound:7950783|FD-Score:2.71|P-value:7.06E-4 ID:SGTC_2869|Compound:9037858|FD-Score:-2.67|P-value:8.17E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.26|P-value:6.19E-5 ID:SGTC_3069|Compound:9117009|FD-Score:3.00|P-value:2.11E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.52|P-value:1.71E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.40|P-value:2.98E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-3.36|P-value:3.69E-5 ID:SGTC_3150|Compound:9097574|FD-Score:3.48|P-value:2.08E-5 ID:SGTC_3155|Compound:9099265|FD-Score:2.67|P-value:8.37E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.34|P-value:4.08E-5 ID:SGTC_3236|Compound:9132701|FD-Score:3.41|P-value:2.98E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.80|P-value:3.90E-6 ID:SGTC_3302|Compound:9125395|FD-Score:3.00|P-value:2.13E-4

Top fitness defect scores for YIL145C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_913 3487-1245 5.06 167.0 µM 1.33E-9 7 2.14E-7
2 SGTC_3244 9134489 3.80 49.5 µM 3.90E-6 21 7.25E-5
3 SGTC_1178 0988-0033 3.72 191.0 µM 5.92E-6 33 9.85E-5
4 SGTC_1175 0741-0056 3.72 27.6 µM 5.97E-6 26 9.90E-5
5 SGTC_3076 9116187 3.52 49.5 µM 1.71E-5 23 2.14E-4
6 SGTC_3150 9097574 3.48 49.5 µM 2.08E-5 18 2.48E-4
7 SGTC_3236 9132701 3.41 49.5 µM 2.98E-5 TSC3-RPN4 43 3.23E-4
8 SGTC_1453 4237-0541 3.36 195.0 µM 3.92E-5 heme biosynthesis & mitochondrial translocase 44 3.94E-4
9 SGTC_3068 9116768 3.26 49.5 µM 6.19E-5 42 5.52E-4
10 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.14 100.0 µM 1.13E-4 68 8.57E-4
11 SGTC_499 genistein 3.05 192.0 µM 1.69E-4 6 0.00115
12 SGTC_522 1273-0010 3.02 11.6 µM 1.89E-4 60S ribosome export 57 0.00126
13 SGTC_3069 9117009 3.00 49.5 µM 2.11E-4 60S ribosome export 26 0.00136
14 SGTC_3302 9125395 3.00 16.4 µM 2.13E-4 48 0.00137
15 SGTC_1568 digitonin 2.91 820.0 nM 3.09E-4 sphingolipid biosynthesis & PDR1 79 0.00180
16 SGTC_99 0109-0120 2.87 622.8 µM 3.61E-4 60 0.00202
17 SGTC_2288 7946289 2.86 167.3 µM 3.92E-4 87 0.00215
18 SGTC_1234 0326-0494 2.86 15.5 µM 3.92E-4 60 0.00215
19 SGTC_807 1315-0151 2.85 48.0 µM 3.99E-4 87 0.00218
20 SGTC_2628 lathosterol 2.76 100.0 µM 5.91E-4 97 0.00291

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.73E-18 YDR408C ADE8 hom Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.121 1.80E-12 YLR167W RPS31 het Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
0.121 2.38E-12 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.110 1.52E-10 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.103 1.99E-9 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.098 1.45E-8 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.097 1.59E-8 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.095 3.23E-8 YMR086C-A_d YMR086C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 6.64E-8 YOR130C ORT1 hom Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
0.089 2.24E-7 YDR288W NSE3 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
0.089 2.61E-7 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.089 2.79E-7 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.087 5.19E-7 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.086 5.83E-7 YMR189W GCV2 hom P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
0.086 5.92E-7 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities