YIL147C / SLN1

Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL147C / SLN1

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:3.10|P-value:3.38E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:2.97|P-value:5.69E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.68|P-value:3.12E-10 ID:SGTC_363|Compound:0455-0021|FD-Score:3.54|P-value:5.27E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.69|P-value:3.01E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.01|P-value:5.57E-6 ID:SGTC_401|Compound:neomycin|FD-Score:-3.19|P-value:2.67E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.23|P-value:1.78E-6 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-4.73|P-value:1.30E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.98|P-value:6.48E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.21|P-value:2.20E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.85|P-value:1.41E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:2.86|P-value:8.69E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.93|P-value:7.22E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.19|P-value:2.40E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.25|P-value:2.08E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.12|P-value:3.19E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.07|P-value:4.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.25|P-value:1.83E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.26|P-value:1.96E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.24|P-value:1.95E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-2.92|P-value:7.44E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.66|P-value:3.10E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.21|P-value:2.40E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-4.08|P-value:4.39E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.24|P-value:4.93E-9 ID:SGTC_1623|Compound:st003709|FD-Score:-4.07|P-value:4.74E-6 ID:SGTC_1738|Compound:st035555|FD-Score:3.59|P-value:4.23E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:2.84|P-value:9.35E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.96|P-value:5.97E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.12|P-value:3.46E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-2.98|P-value:5.98E-4 ID:SGTC_2936|Compound:9038235|FD-Score:2.88|P-value:7.87E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.45|P-value:6.50E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-4.40|P-value:8.17E-7 ID:SGTC_107|Compound:0358-0022|FD-Score:3.10|P-value:3.38E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:2.97|P-value:5.69E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.68|P-value:3.12E-10 ID:SGTC_363|Compound:0455-0021|FD-Score:3.54|P-value:5.27E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.69|P-value:3.01E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.01|P-value:5.57E-6 ID:SGTC_401|Compound:neomycin|FD-Score:-3.19|P-value:2.67E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.23|P-value:1.78E-6 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-4.73|P-value:1.30E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.98|P-value:6.48E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.21|P-value:2.20E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.85|P-value:1.41E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:2.86|P-value:8.69E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.93|P-value:7.22E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.19|P-value:2.40E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.25|P-value:2.08E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.12|P-value:3.19E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.07|P-value:4.15E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.25|P-value:1.83E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.26|P-value:1.96E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.24|P-value:1.95E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-2.92|P-value:7.44E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.66|P-value:3.10E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.21|P-value:2.40E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-4.08|P-value:4.39E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.24|P-value:4.93E-9 ID:SGTC_1623|Compound:st003709|FD-Score:-4.07|P-value:4.74E-6 ID:SGTC_1738|Compound:st035555|FD-Score:3.59|P-value:4.23E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:2.84|P-value:9.35E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.96|P-value:5.97E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.12|P-value:3.46E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-2.98|P-value:5.98E-4 ID:SGTC_2936|Compound:9038235|FD-Score:2.88|P-value:7.87E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.45|P-value:6.50E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-4.40|P-value:8.17E-7

Top fitness defect scores for YIL147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1576 erythromycin ethylsuccinate 5.24 23.2 µM 4.93E-9 2 8.01E-8 0.78
2 SGTC_409 arachidonic acid 4.23 100.0 µM 1.78E-6 1 1.14E-5 0.36
3 SGTC_367 0335-0881 4.01 7.1 µM 5.57E-6 ubiquinone biosynthesis & proteasome 23 2.99E-5 0.16
4 SGTC_412 gemfibrozil 3.98 100.0 µM 6.48E-6 DNA intercalators 6 3.40E-5 0.16
5 SGTC_1343 1487-0095 3.66 224.0 µM 3.10E-5 2 1.27E-4 0.23
6 SGTC_1738 st035555 3.59 74.0 µM 4.23E-5 TSC3-RPN4 8 1.66E-4 0.05
7 SGTC_363 0455-0021 3.54 3.1 µM 5.27E-5 azole & statin 22 2.00E-4 0.02
8 SGTC_1171 0368-0077 3.25 21.4 µM 1.83E-4 20 5.73E-4 0.04
9 SGTC_1216 1165-0504 3.24 9.7 µM 1.95E-4 9 6.03E-4 0.04
10 SGTC_497 capsazepine 3.21 133.0 µM 2.20E-4 11 6.69E-4 0.02
11 SGTC_807 1315-0151 3.19 48.0 µM 2.40E-4 20 7.18E-4 0.03
12 SGTC_1004 4084-0029 3.12 199.0 µM 3.19E-4 9 9.14E-4 0.11
13 SGTC_107 0358-0022 3.10 2.7 µM 3.38E-4 SWF1 & branched chain AA biosynthesis 8 9.60E-4 0.11
14 SGTC_119 0121-0043 2.97 24.8 µM 5.69E-4 mitochondrial stress 39 0.00149 0.04
15 SGTC_2398 5228213 2.96 48.8 µM 5.97E-4 iron homeostasis 32 0.00155 0.06
16 SGTC_2936 9038235 2.88 15.6 µM 7.87E-4 26 0.00196 0.00
17 SGTC_608 k048-0125 2.86 159.0 µM 8.69E-4 16 0.00214 0.01
18 SGTC_1789 tunicamycin 2.84 25.0 nM 9.35E-4 unfolded protein response 37 0.00228 0.12
19 SGTC_1602 st001878 2.81 87.6 µM 0.00104 28 0.00248 0.04
20 SGTC_593 1203-0218 2.74 61.7 µM 0.00135 19 0.00310 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 5.04E-22 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.163 2.10E-21 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.160 8.96E-21 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.152 8.35E-19 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.150 2.81E-18 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.149 3.16E-18 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.149 5.08E-18 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.145 3.47E-17 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.144 5.19E-17 YGL048C RPT6 het ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
0.140 3.68E-16 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.135 3.49E-15 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.135 3.60E-15 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.135 3.69E-15 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.135 4.17E-15 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.134 8.07E-15 YJR076C CDC11 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells