YIL152W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL152W / YIL152W

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.03|P-value:3.79E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.51|P-value:4.86E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.20|P-value:1.98E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.05|P-value:3.63E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.80|P-value:9.40E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.01|P-value:4.22E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.25|P-value:1.23E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-2.92|P-value:6.15E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.04|P-value:3.65E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.71|P-value:1.89E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:4.13|P-value:2.36E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.01|P-value:4.26E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-2.90|P-value:6.70E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.12|P-value:2.66E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.33|P-value:1.14E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.39|P-value:5.67E-7 ID:SGTC_1220|Compound:1838-0075|FD-Score:-2.90|P-value:6.71E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:2.94|P-value:5.50E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.97|P-value:1.82E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.99|P-value:1.68E-8 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.97|P-value:5.24E-6 ID:SGTC_1594|Compound:piperine|FD-Score:3.36|P-value:9.82E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.40|P-value:5.35E-7 ID:SGTC_1635|Compound:st007035|FD-Score:-4.63|P-value:1.51E-7 ID:SGTC_1638|Compound:st008370|FD-Score:7.87|P-value:1.36E-18 ID:SGTC_1834|Compound:st055981|FD-Score:-3.21|P-value:1.92E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.00|P-value:4.43E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.88|P-value:8.71E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-2.91|P-value:6.31E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.10|P-value:2.92E-4 ID:SGTC_2426|Compound:5582046|FD-Score:2.97|P-value:4.91E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.65|P-value:1.31E-7 ID:SGTC_2832|Compound:7992762|FD-Score:-4.27|P-value:1.14E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-2.80|P-value:9.75E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.78|P-value:1.37E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.11|P-value:2.80E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-2.80|P-value:9.80E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.20|P-value:2.02E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.06|P-value:3.39E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.84|P-value:1.04E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-4.69|P-value:1.01E-7 ID:SGTC_3355|Compound:9151058|FD-Score:-3.14|P-value:2.58E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.10|P-value:3.02E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:3.03|P-value:3.79E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.51|P-value:4.86E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.20|P-value:1.98E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.05|P-value:3.63E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.80|P-value:9.40E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.01|P-value:4.22E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.25|P-value:1.23E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-2.92|P-value:6.15E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.04|P-value:3.65E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.71|P-value:1.89E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:4.13|P-value:2.36E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.01|P-value:4.26E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-2.90|P-value:6.70E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.12|P-value:2.66E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.33|P-value:1.14E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.39|P-value:5.67E-7 ID:SGTC_1220|Compound:1838-0075|FD-Score:-2.90|P-value:6.71E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:2.94|P-value:5.50E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.97|P-value:1.82E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.99|P-value:1.68E-8 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.97|P-value:5.24E-6 ID:SGTC_1594|Compound:piperine|FD-Score:3.36|P-value:9.82E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.40|P-value:5.35E-7 ID:SGTC_1635|Compound:st007035|FD-Score:-4.63|P-value:1.51E-7 ID:SGTC_1638|Compound:st008370|FD-Score:7.87|P-value:1.36E-18 ID:SGTC_1834|Compound:st055981|FD-Score:-3.21|P-value:1.92E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.00|P-value:4.43E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.88|P-value:8.71E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-2.91|P-value:6.31E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.10|P-value:2.92E-4 ID:SGTC_2426|Compound:5582046|FD-Score:2.97|P-value:4.91E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.65|P-value:1.31E-7 ID:SGTC_2832|Compound:7992762|FD-Score:-4.27|P-value:1.14E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-2.80|P-value:9.75E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.78|P-value:1.37E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.11|P-value:2.80E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-2.80|P-value:9.80E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.20|P-value:2.02E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.06|P-value:3.39E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.84|P-value:1.04E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-4.69|P-value:1.01E-7 ID:SGTC_3355|Compound:9151058|FD-Score:-3.14|P-value:2.58E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.10|P-value:3.02E-4

Top fitness defect scores for YIL152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1638 st008370 7.87 60.6 µM 1.36E-18 ergosterol biosynthesis 5 1.82E-15
2 SGTC_1631 benzylvanillin 4.40 81.9 µM 5.35E-7 Golgi 19 5.47E-6
3 SGTC_1086 cerivastatin 4.39 2.2 µM 5.67E-7 azole & statin 7 5.73E-6
4 SGTC_427 1354-0053 4.25 47.3 µM 1.23E-6 13 1.08E-5
5 SGTC_632 0781-2353 4.13 4.7 µM 2.36E-6 Golgi 38 1.84E-5
6 SGTC_1583 clindamycin 3.97 39.6 µM 5.24E-6 mitochondrial processes 12 3.56E-5
7 SGTC_3349 9149703 3.84 23.0 µM 1.04E-5 17 6.23E-5
8 SGTC_2970 9090938 3.78 41.9 µM 1.37E-5 RNA processing & uracil transport 44 7.84E-5
9 SGTC_538 2922-0838 3.71 53.3 µM 1.89E-5 Golgi 37 1.02E-4
10 SGTC_30 5-(2-thienylidene)-Rhodanine 3.51 28.7 µM 4.86E-5 11 2.22E-4
11 SGTC_1594 piperine 3.36 70.1 µM 9.82E-5 30 3.95E-4
12 SGTC_936 3005-4620 3.12 401.0 µM 2.66E-4 65 8.98E-4
13 SGTC_3133 9127736 3.11 49.5 µM 2.80E-4 50 9.36E-4
14 SGTC_2288 7946289 3.10 167.3 µM 2.92E-4 73 9.71E-4
15 SGTC_3305 9127027 3.06 53.8 µM 3.39E-4 53 0.00110
16 SGTC_251 melphalan 3.05 456.5 µM 3.63E-4 DNA damage response 71 0.00116
17 SGTC_531 3788-1495 3.04 174.0 µM 3.65E-4 unfolded protein response 64 0.00117
18 SGTC_2 0422-0095 3.03 29.0 µM 3.79E-4 redox potentiating 18 0.00120
19 SGTC_310 1273-0058 3.01 1.1 µM 4.22E-4 mitochondrial stress 347 0.00132
20 SGTC_1855 st056195 3.00 39.6 µM 4.43E-4 60S ribosome export 63 0.00137

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 3.40E-40 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.222 7.05E-39 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.214 5.40E-36 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.204 6.02E-33 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.200 1.86E-31 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.192 2.81E-29 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.190 1.52E-28 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.188 4.38E-28 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.188 4.52E-28 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.176 9.59E-25 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.174 4.22E-24 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.172 8.74E-24 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.172 9.63E-24 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.171 2.23E-23 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.171 2.77E-23 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress