Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.226 |
3.40E-40 |
YJL171C |
YJL171C |
hom |
GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress |
0.222 |
7.05E-39 |
YGR022C_d |
YGR022C_d |
hom |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W |
0.214 |
5.40E-36 |
YNL166C |
BNI5 |
hom |
Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner |
0.204 |
6.02E-33 |
YDR521W_d |
YDR521W_d |
hom |
Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol |
0.200 |
1.86E-31 |
YGR072W |
UPF3 |
hom |
Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance |
0.192 |
2.81E-29 |
YGR077C |
PEX8 |
hom |
Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p |
0.190 |
1.52E-28 |
YMR322C_p |
SNO4_p |
hom |
Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation |
0.188 |
4.38E-28 |
YJR137C |
MET5 |
hom |
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine |
0.188 |
4.52E-28 |
YBL017C |
PEP1 |
hom |
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments |
0.176 |
9.59E-25 |
YDL176W |
YDL176W |
hom |
Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene |
0.174 |
4.22E-24 |
YPR180W |
AOS1 |
het |
Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
0.172 |
8.74E-24 |
YFL014W |
HSP12 |
hom |
Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension |
0.172 |
9.63E-24 |
YDR169C |
STB3 |
hom |
Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress |
0.171 |
2.23E-23 |
YDR312W |
SSF2 |
hom |
Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication |
0.171 |
2.77E-23 |
YGR136W |
LSB1 |
hom |
Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress |