YIL160C / POT1

3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL160C / POT1

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.11|P-value:6.38E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.33|P-value:2.59E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:17.30|P-value:1.01E-72 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.08|P-value:7.10E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.10|P-value:5.99E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.12|P-value:9.45E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.28|P-value:4.35E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-4.52|P-value:1.36E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:-5.14|P-value:4.61E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-6.13|P-value:9.32E-11 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-4.15|P-value:8.18E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:3.20|P-value:4.13E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.28|P-value:2.06E-8 ID:SGTC_911|Compound:3456-4043|FD-Score:3.00|P-value:8.59E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.43|P-value:1.94E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.19|P-value:4.32E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.32|P-value:2.63E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.41|P-value:1.88E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.62|P-value:7.79E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:9.21|P-value:4.22E-22 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.50|P-value:1.30E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.92|P-value:2.14E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.20|P-value:4.55E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.72|P-value:5.26E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-3.29|P-value:3.15E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.41|P-value:1.99E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.68|P-value:6.66E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.77|P-value:4.29E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.26|P-value:3.54E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.82|P-value:6.04E-13 ID:SGTC_2606|Compound:farnesol|FD-Score:3.49|P-value:1.35E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.06|P-value:1.36E-10 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.55|P-value:1.14E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.14|P-value:5.63E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.04|P-value:7.62E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.11|P-value:6.38E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.33|P-value:2.59E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:17.30|P-value:1.01E-72 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.08|P-value:7.10E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.10|P-value:5.99E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.12|P-value:9.45E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.28|P-value:4.35E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:-4.52|P-value:1.36E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:-5.14|P-value:4.61E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-6.13|P-value:9.32E-11 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-4.15|P-value:8.18E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:3.20|P-value:4.13E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.28|P-value:2.06E-8 ID:SGTC_911|Compound:3456-4043|FD-Score:3.00|P-value:8.59E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.43|P-value:1.94E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.19|P-value:4.32E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.32|P-value:2.63E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.41|P-value:1.88E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.62|P-value:7.79E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:9.21|P-value:4.22E-22 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.17|P-value:4.73E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.50|P-value:1.30E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.92|P-value:2.14E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.20|P-value:4.55E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.72|P-value:5.26E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-3.29|P-value:3.15E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.41|P-value:1.99E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.68|P-value:6.66E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.77|P-value:4.29E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.26|P-value:3.54E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.82|P-value:6.04E-13 ID:SGTC_2606|Compound:farnesol|FD-Score:3.49|P-value:1.35E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.06|P-value:1.36E-10 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.55|P-value:1.14E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.14|P-value:5.63E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.04|P-value:7.62E-4

Top fitness defect scores for YIL160C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 17.30 9.0 µM 1.01E-72 cell wall 20 2.93E-67
2 SGTC_1309 pyrazolanthrone 9.21 13.4 µM 4.22E-22 3 1.61E-20
3 SGTC_2582 agaric acid 6.82 100.0 µM 6.04E-13 redox potentiating 133 4.61E-12
4 SGTC_2651 1327-0036 6.06 5.0 µM 1.36E-10 72 6.89E-10
5 SGTC_937 3122-0005 4.43 46.7 µM 1.94E-6 17 4.76E-6
6 SGTC_1713 st033146 3.92 12.8 µM 2.14E-5 27 4.37E-5
7 SGTC_2040 5100729 3.77 123.0 µM 4.29E-5 46 8.33E-5
8 SGTC_2015 5119600 3.72 184.0 µM 5.26E-5 36 1.01E-4
9 SGTC_1263 0774-1208 3.62 64.8 µM 7.79E-5 58 1.45E-4
10 SGTC_1600 coumarin 106 3.50 71.1 µM 1.30E-4 39 2.33E-4
11 SGTC_2606 farnesol 3.49 9.8 µM 1.35E-4 33 2.40E-4
12 SGTC_1258 0671-0043 3.41 57.1 µM 1.88E-4 42 3.27E-4
13 SGTC_57 miconazole 3.33 162.5 nM 2.59E-4 ergosterol depletion effects on membrane 40 4.40E-4
14 SGTC_1054 3429-0080 3.32 167.0 µM 2.63E-4 47 4.46E-4
15 SGTC_413 propylparaben 3.20 100.0 µM 4.13E-4 amide catabolism 46 6.78E-4
16 SGTC_938 3126-1755 3.19 342.0 µM 4.32E-4 33 7.06E-4
17 SGTC_1215 3852-0577 3.18 11.2 µM 4.56E-4 41 7.43E-4
18 SGTC_1434 4073-0095 3.17 163.0 µM 4.73E-4 33 7.68E-4
19 SGTC_266 formosanin C 3.10 406.0 nM 5.99E-4 sphingolipid biosynthesis & PDR1 102 9.57E-4
20 SGTC_154 3389-1638 3.07 511.1 µM 6.88E-4 60 0.00109

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.439 4.14E-158 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.422 1.95E-145 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.400 5.77E-129 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.387 2.55E-120 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.375 5.33E-112 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.341 4.72E-92 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.330 5.05E-86 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.324 9.28E-83 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.322 1.19E-81 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.319 1.82E-80 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.318 7.99E-80 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.313 2.93E-77 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.305 2.71E-73 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.304 8.58E-73 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.294 5.40E-68 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M