YIL161W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL161W / YIL161W

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:4.16|P-value:2.40E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:5.60|P-value:3.66E-10 ID:SGTC_309|Compound:k408-0051|FD-Score:2.96|P-value:5.78E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-2.97|P-value:5.38E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:2.85|P-value:8.51E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-2.85|P-value:8.66E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.38|P-value:1.03E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.72|P-value:1.04E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:2.84|P-value:9.08E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-2.97|P-value:5.49E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:2.83|P-value:9.49E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-4.72|P-value:1.09E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:3.10|P-value:3.31E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.09|P-value:3.47E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:-2.81|P-value:9.93E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:2.87|P-value:8.10E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.10|P-value:3.25E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.59|P-value:3.92E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.00|P-value:4.81E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.46|P-value:7.18E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.31|P-value:1.35E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-2.83|P-value:9.20E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.90|P-value:7.29E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.09|P-value:3.38E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:3.96E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.88|P-value:7.62E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-2.95|P-value:5.85E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.86|P-value:2.30E-14 ID:SGTC_2060|Compound:5238662|FD-Score:4.93|P-value:2.99E-8 ID:SGTC_2083|Compound:5306046|FD-Score:4.00|P-value:5.59E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.37|P-value:1.04E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.20|P-value:2.15E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.10|P-value:3.25E-4 ID:SGTC_2215|Compound:7188065|FD-Score:2.94|P-value:6.24E-4 ID:SGTC_2238|Compound:6671620|FD-Score:2.91|P-value:6.80E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.02|P-value:4.95E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-3.08|P-value:3.62E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.60|P-value:3.76E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.80|P-value:1.47E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.65|P-value:3.05E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.39|P-value:9.64E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.02|P-value:4.45E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.12|P-value:2.97E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.87|P-value:8.10E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.49|P-value:4.01E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.74|P-value:9.26E-8 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:2.93|P-value:6.44E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.13|P-value:2.90E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.53|P-value:5.31E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.37|P-value:1.07E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:2.83|P-value:9.46E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.20|P-value:2.22E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.49|P-value:6.20E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.35|P-value:1.13E-4 ID:SGTC_2936|Compound:9038235|FD-Score:7.62|P-value:2.63E-17 ID:SGTC_2971|Compound:9092186|FD-Score:-4.20|P-value:1.91E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.16|P-value:2.40E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:5.60|P-value:3.66E-10 ID:SGTC_309|Compound:k408-0051|FD-Score:2.96|P-value:5.78E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-2.97|P-value:5.38E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:2.85|P-value:8.51E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-2.85|P-value:8.66E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.38|P-value:1.03E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:4.72|P-value:1.04E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:2.84|P-value:9.08E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-2.97|P-value:5.49E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:2.83|P-value:9.49E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-4.72|P-value:1.09E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:3.10|P-value:3.31E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.09|P-value:3.47E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:-2.81|P-value:9.93E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:2.87|P-value:8.10E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.10|P-value:3.25E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.59|P-value:3.92E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.00|P-value:4.81E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.46|P-value:7.18E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.31|P-value:1.35E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-2.83|P-value:9.20E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.90|P-value:7.29E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.09|P-value:3.38E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:3.96E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.88|P-value:7.62E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-2.95|P-value:5.85E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.86|P-value:2.30E-14 ID:SGTC_2060|Compound:5238662|FD-Score:4.93|P-value:2.99E-8 ID:SGTC_2083|Compound:5306046|FD-Score:4.00|P-value:5.59E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.37|P-value:1.04E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.20|P-value:2.15E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.10|P-value:3.25E-4 ID:SGTC_2215|Compound:7188065|FD-Score:2.94|P-value:6.24E-4 ID:SGTC_2238|Compound:6671620|FD-Score:2.91|P-value:6.80E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-4.02|P-value:4.95E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-3.08|P-value:3.62E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.60|P-value:3.76E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.80|P-value:1.47E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.65|P-value:3.05E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.39|P-value:9.64E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.02|P-value:4.45E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.12|P-value:2.97E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.87|P-value:8.10E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.49|P-value:4.01E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.74|P-value:9.26E-8 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:2.93|P-value:6.44E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.13|P-value:2.90E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.53|P-value:5.31E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.37|P-value:1.07E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:2.83|P-value:9.46E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.20|P-value:2.22E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.49|P-value:6.20E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.35|P-value:1.13E-4 ID:SGTC_2936|Compound:9038235|FD-Score:7.62|P-value:2.63E-17 ID:SGTC_2971|Compound:9092186|FD-Score:-4.20|P-value:1.91E-6

Top fitness defect scores for YIL161W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2936 9038235 7.62 15.6 µM 2.63E-17 1 1.23E-14
2 SGTC_266 formosanin C 5.60 406.0 nM 3.66E-10 sphingolipid biosynthesis & PDR1 34 1.05E-8
3 SGTC_2060 5238662 4.93 140.0 µM 2.99E-8 13 4.11E-7
4 SGTC_2539 epi(13)torulosol 4.74 80.0 µM 9.26E-8 12 1.05E-6
5 SGTC_606 k015-0008 4.72 38.6 µM 1.04E-7 3 1.16E-6
6 SGTC_119 0121-0043 4.16 24.8 µM 2.40E-6 mitochondrial stress 94 1.59E-5
7 SGTC_2083 5306046 4.00 65.9 µM 5.59E-6 27 3.22E-5
8 SGTC_2283 7944793 3.80 200.0 µM 1.47E-5 54 7.21E-5
9 SGTC_2325 6158266 3.65 200.0 µM 3.05E-5 35 1.33E-4
10 SGTC_2282 7944268 3.60 200.0 µM 3.76E-5 RPP1 & pyrimidine depletion 45 1.58E-4
11 SGTC_991 3996-0057 3.59 64.7 µM 3.92E-5 28 1.64E-4
12 SGTC_2651 1327-0036 3.53 5.0 µM 5.31E-5 193 2.11E-4
13 SGTC_2850 9015429 3.49 58.4 µM 6.20E-5 25 2.40E-4
14 SGTC_1181 1222-0449 3.46 220.0 µM 7.18E-5 38 2.72E-4
15 SGTC_2396 5342950 3.39 42.8 µM 9.64E-5 RSC complex & mRNA processing 74 3.48E-4
16 SGTC_565 1418-0001 3.38 44.5 µM 1.03E-4 43 3.69E-4
17 SGTC_2086 5274770 3.37 176.6 µM 1.04E-4 45 3.72E-4
18 SGTC_2654 protoveratrine a 3.37 100.0 µM 1.07E-4 21 3.78E-4
19 SGTC_2856 9022925 3.35 19.5 µM 1.13E-4 44 3.98E-4
20 SGTC_1224 0823-0416 3.31 294.0 µM 1.35E-4 28 4.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.59E-21 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.129 6.11E-14 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.125 4.39E-13 YLR438C-A LSM3 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.118 6.08E-12 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.110 1.46E-10 YPL173W MRPL40 hom Mitochondrial ribosomal protein of the large subunit
0.110 1.57E-10 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.105 9.88E-10 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.105 1.04E-9 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.104 1.82E-9 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.102 3.90E-9 YDR365C ESF1 het Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
0.101 4.17E-9 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.099 8.08E-9 YPR130C_d YPR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.34E-8 YDR037W KRS1 het Lysyl-tRNA synthetase
0.098 1.42E-8 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.096 2.33E-8 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters