YIL173W / VTH1

Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL173W / VTH1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.85|P-value:5.40E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.22|P-value:1.07E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.29|P-value:7.90E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.11|P-value:1.57E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.42|P-value:4.19E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-2.70|P-value:8.75E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.05|P-value:1.64E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.34|P-value:6.29E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:2.70|P-value:9.64E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.78|P-value:6.47E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.86|P-value:5.18E-4 ID:SGTC_456|Compound:gingerol|FD-Score:2.88|P-value:4.78E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-2.71|P-value:8.58E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:2.94|P-value:3.64E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.55|P-value:2.25E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:2.71|P-value:9.19E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.72|P-value:8.20E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.63|P-value:1.38E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.12|P-value:1.72E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.10|P-value:1.82E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.28|P-value:8.13E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.15|P-value:1.35E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.59|P-value:1.87E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-5.72|P-value:1.91E-11 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.04|P-value:2.18E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.96|P-value:3.43E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-4.40|P-value:1.80E-7 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.96|P-value:2.32E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.84|P-value:5.24E-6 ID:SGTC_1976|Compound:st070609|FD-Score:2.70|P-value:9.59E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.73|P-value:7.93E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.54|P-value:2.34E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.71|P-value:1.02E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.19|P-value:1.25E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.26|P-value:8.01E-5 ID:SGTC_2123|Compound:5259487|FD-Score:-2.67|P-value:9.95E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.56|P-value:1.94E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.12|P-value:1.08E-6 ID:SGTC_2295|Compound:7971645|FD-Score:3.68|P-value:1.17E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-3.83|P-value:4.86E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.22|P-value:6.06E-7 ID:SGTC_2480|Compound:5767542|FD-Score:-2.93|P-value:3.43E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.87|P-value:4.43E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:2.86|P-value:5.04E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.42|P-value:4.28E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.30|P-value:7.45E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.75|P-value:8.16E-6 ID:SGTC_3187|Compound:9109394|FD-Score:4.23|P-value:5.88E-7 ID:SGTC_3228|Compound:9131799|FD-Score:2.95|P-value:3.55E-4 ID:SGTC_3229|Compound:9132204|FD-Score:2.88|P-value:4.77E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.53|P-value:2.52E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:2.85|P-value:5.40E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.22|P-value:1.07E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.29|P-value:7.90E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.11|P-value:1.57E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.42|P-value:4.19E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-2.70|P-value:8.75E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:4.05|P-value:1.64E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.34|P-value:6.29E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:2.70|P-value:9.64E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.78|P-value:6.47E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.86|P-value:5.18E-4 ID:SGTC_456|Compound:gingerol|FD-Score:2.88|P-value:4.78E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-2.71|P-value:8.58E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:2.94|P-value:3.64E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.55|P-value:2.25E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:2.71|P-value:9.19E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.72|P-value:8.20E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.63|P-value:1.38E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.12|P-value:1.72E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.10|P-value:1.82E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.28|P-value:8.13E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.15|P-value:1.35E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.59|P-value:1.87E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-5.72|P-value:1.91E-11 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.04|P-value:2.18E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.96|P-value:3.43E-4 ID:SGTC_1964|Compound:st076914|FD-Score:-4.40|P-value:1.80E-7 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.96|P-value:2.32E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.84|P-value:5.24E-6 ID:SGTC_1976|Compound:st070609|FD-Score:2.70|P-value:9.59E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.73|P-value:7.93E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.54|P-value:2.34E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.71|P-value:1.02E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.19|P-value:1.25E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.26|P-value:8.01E-5 ID:SGTC_2123|Compound:5259487|FD-Score:-2.67|P-value:9.95E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.56|P-value:1.94E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.12|P-value:1.08E-6 ID:SGTC_2295|Compound:7971645|FD-Score:3.68|P-value:1.17E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-3.83|P-value:4.86E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.22|P-value:6.06E-7 ID:SGTC_2480|Compound:5767542|FD-Score:-2.93|P-value:3.43E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.87|P-value:4.43E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:2.86|P-value:5.04E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.42|P-value:4.28E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.30|P-value:7.45E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.75|P-value:8.16E-6 ID:SGTC_3187|Compound:9109394|FD-Score:4.23|P-value:5.88E-7 ID:SGTC_3228|Compound:9131799|FD-Score:2.95|P-value:3.55E-4 ID:SGTC_3229|Compound:9132204|FD-Score:2.88|P-value:4.77E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.53|P-value:2.52E-5

Top fitness defect scores for YIL173W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3187 9109394 4.23 49.5 µM 5.88E-7 Golgi 16 1.18E-5
2 SGTC_2479 5617353 4.22 43.9 µM 6.06E-7 29 1.20E-5
3 SGTC_2282 7944268 4.12 200.0 µM 1.08E-6 RPP1 & pyrimidine depletion 27 1.88E-5
4 SGTC_380 3970-0968 4.05 6.0 µM 1.64E-6 11 2.58E-5
5 SGTC_1975 st070967 3.84 30.8 µM 5.24E-6 39 6.26E-5
6 SGTC_3162 9099653 3.75 49.5 µM 8.16E-6 8 8.78E-5
7 SGTC_2103 5378138 3.71 10.0 µM 1.02E-5 22 1.04E-4
8 SGTC_2295 7971645 3.68 200.0 µM 1.17E-5 30 1.16E-4
9 SGTC_1276 0871-0068 3.59 94.2 µM 1.87E-5 25 1.66E-4
10 SGTC_686 1319-0111 3.55 510.0 µM 2.25E-5 60S ribosome export 40 1.91E-4
11 SGTC_2096 5468907 3.54 200.0 µM 2.34E-5 17 1.97E-4
12 SGTC_3327 9140648 3.53 26.9 µM 2.52E-5 20 2.08E-4
13 SGTC_358 0075-0058 3.42 9.4 µM 4.19E-5 90 3.08E-4
14 SGTC_2621 lithochol-11-enic acid 3.42 100.0 µM 4.28E-5 46 3.13E-4
15 SGTC_387 norethindrone acetate 3.34 66.7 µM 6.29E-5 36 4.21E-4
16 SGTC_2837 9008476 3.30 45.5 µM 7.45E-5 60 4.79E-4
17 SGTC_41 0478-0632 3.29 82.6 µM 7.90E-5 55 5.01E-4
18 SGTC_1059 3448-6867 3.28 171.0 µM 8.13E-5 30 5.12E-4
19 SGTC_39 0986-0283 3.22 58.4 µM 1.07E-4 calcium & mitochondrial duress 67 6.32E-4
20 SGTC_2108 5365811 3.19 200.0 µM 1.25E-4 47 7.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 4.36E-31 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.135 3.99E-15 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.131 2.10E-14 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.124 4.69E-13 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.121 2.37E-12 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.119 4.12E-12 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.118 7.96E-12 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.117 1.08E-11 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.103 2.30E-9 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.100 5.82E-9 YKL106W AAT1 hom Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
0.099 7.70E-9 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.099 8.36E-9 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.095 3.05E-8 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.095 3.30E-8 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.095 3.87E-8 YGR199W PMT6 hom Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases