YIR004W / DJP1

Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR004W / DJP1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.00|P-value:7.26E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.14|P-value:5.74E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.03|P-value:6.49E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.07|P-value:7.28E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.19|P-value:4.81E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.01|P-value:9.31E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.40|P-value:1.58E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.67|P-value:5.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.04|P-value:1.39E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.22|P-value:3.13E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.46|P-value:1.19E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.27|P-value:2.64E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.18|P-value:3.75E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.87|P-value:2.10E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.44|P-value:1.95E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.40|P-value:2.15E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.17|P-value:5.06E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.47|P-value:1.18E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.63|P-value:4.89E-7 ID:SGTC_1630|Compound:st005209|FD-Score:3.61|P-value:6.68E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.99|P-value:7.51E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.33|P-value:2.74E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.17|P-value:3.91E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.46|P-value:1.67E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.26|P-value:2.73E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.83|P-value:2.58E-7 ID:SGTC_1936|Compound:st074407|FD-Score:-3.06|P-value:7.78E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.00|P-value:7.14E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.30|P-value:2.35E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.18|P-value:4.99E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.02|P-value:6.82E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.41|P-value:2.08E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.34|P-value:3.31E-6 ID:SGTC_2814|Compound:7977482|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-11.10|P-value:3.47E-31 ID:SGTC_3210|Compound:9128157|FD-Score:4.00|P-value:1.16E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.90|P-value:1.86E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:3.00|P-value:7.26E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.14|P-value:5.74E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.03|P-value:6.49E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.07|P-value:7.28E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.19|P-value:4.81E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.01|P-value:9.31E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.40|P-value:1.58E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.67|P-value:5.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.04|P-value:1.39E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.22|P-value:3.13E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.46|P-value:1.19E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.27|P-value:2.64E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.18|P-value:3.75E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.87|P-value:2.10E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.44|P-value:1.95E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.40|P-value:2.15E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.17|P-value:5.06E-6 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.47|P-value:1.18E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.63|P-value:4.89E-7 ID:SGTC_1630|Compound:st005209|FD-Score:3.61|P-value:6.68E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.99|P-value:7.51E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-3.33|P-value:2.74E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.17|P-value:3.91E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.46|P-value:1.67E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.26|P-value:2.73E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.83|P-value:2.58E-7 ID:SGTC_1936|Compound:st074407|FD-Score:-3.06|P-value:7.78E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.00|P-value:7.14E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.30|P-value:2.35E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.18|P-value:4.99E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.02|P-value:6.82E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.41|P-value:2.08E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.34|P-value:3.31E-6 ID:SGTC_2814|Compound:7977482|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-11.10|P-value:3.47E-31 ID:SGTC_3210|Compound:9128157|FD-Score:4.00|P-value:1.16E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.90|P-value:1.86E-5

Top fitness defect scores for YIR004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1600 coumarin 106 4.63 71.1 µM 4.89E-7 14 1.80E-6
2 SGTC_778 3456-2434 4.46 196.0 µM 1.19E-6 mitochondrial response to ROS 58 4.03E-6
3 SGTC_1295 1013-0063 4.17 9.8 µM 5.06E-6 5 1.50E-5
4 SGTC_3210 9128157 4.00 49.5 µM 1.16E-5 47 3.18E-5
5 SGTC_3342 9147791 3.90 14.5 µM 1.86E-5 16 4.87E-5
6 SGTC_989 1501-0895 3.87 10.3 µM 2.10E-5 9 5.44E-5
7 SGTC_634 1611-4317 3.67 11.2 µM 5.12E-5 ERG2 21 1.22E-4
8 SGTC_1630 st005209 3.61 31.3 µM 6.68E-5 35 1.55E-4
9 SGTC_1382 3002-2117 3.47 298.0 µM 1.18E-4 22 2.60E-4
10 SGTC_956 1185-0240 3.45 191.0 µM 1.27E-4 39 2.79E-4
11 SGTC_1233 0325-0408 3.42 14.2 µM 1.47E-4 36 3.18E-4
12 SGTC_559 1550-0661 3.40 158.0 µM 1.58E-4 19 3.40E-4
13 SGTC_2335 9018011 3.36 154.2 µM 1.81E-4 45 3.83E-4
14 SGTC_1783 st039459 3.33 87.5 µM 2.04E-4 Golgi 40 4.28E-4
15 SGTC_1975 st070967 3.30 30.8 µM 2.35E-4 60 4.87E-4
16 SGTC_779 1360-0071 3.27 233.0 µM 2.64E-4 fatty acid desaturase (OLE1) 62 5.39E-4
17 SGTC_1919 st067113 3.26 52.3 µM 2.73E-4 TSC3-RPN4 58 5.57E-4
18 SGTC_2814 7977482 3.24 43.0 µM 2.98E-4 85 6.02E-4
19 SGTC_777 1315-0167 3.22 517.0 µM 3.13E-4 Golgi 52 6.30E-4
20 SGTC_2027 5150920 3.19 200.0 µM 3.52E-4 36 7.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.03E-33 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.169 7.28E-23 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.169 8.40E-23 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.162 3.28E-21 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.155 1.86E-19 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.134 7.09E-15 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.132 1.37E-14 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.128 1.24E-13 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.126 2.66E-13 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.125 3.10E-13 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.124 4.75E-13 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.121 1.68E-12 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.121 1.64E-12 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.121 2.40E-12 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.118 7.50E-12 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W