YIR007W_p

Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR007W / YIR007W

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:-3.16|P-value:5.45E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.59|P-value:1.03E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-4.98|P-value:1.28E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.47|P-value:1.66E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:4.39|P-value:2.59E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:2.98|P-value:9.54E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.22|P-value:4.03E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.92|P-value:3.30E-13 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.45|P-value:1.66E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.16|P-value:7.57E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:3.24E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.58|P-value:1.05E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.78|P-value:4.22E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.11|P-value:9.69E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.31|P-value:2.84E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.48|P-value:1.48E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.47|P-value:1.69E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.43|P-value:1.94E-4 ID:SGTC_2366|Compound:9070441|FD-Score:5.05|P-value:7.71E-8 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.01|P-value:9.17E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.42|P-value:1.99E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.97|P-value:9.88E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.63|P-value:2.47E-9 ID:SGTC_2805|Compound:7950783|FD-Score:-3.97|P-value:2.04E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.00|P-value:9.13E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.13|P-value:5.64E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.44|P-value:1.72E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-4.02|P-value:1.59E-5 ID:SGTC_3273|Compound:9137859|FD-Score:-4.11|P-value:1.06E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.16|P-value:5.45E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.59|P-value:1.03E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-4.98|P-value:1.28E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.47|P-value:1.66E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:4.39|P-value:2.59E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:2.98|P-value:9.54E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.22|P-value:4.03E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.92|P-value:3.30E-13 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.45|P-value:1.66E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.16|P-value:7.57E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:3.24E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.58|P-value:1.05E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.78|P-value:4.22E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.11|P-value:9.69E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.31|P-value:2.84E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.48|P-value:1.48E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.47|P-value:1.69E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-3.43|P-value:1.94E-4 ID:SGTC_2366|Compound:9070441|FD-Score:5.05|P-value:7.71E-8 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.01|P-value:9.17E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.42|P-value:1.99E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.97|P-value:9.88E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.63|P-value:2.47E-9 ID:SGTC_2805|Compound:7950783|FD-Score:-3.97|P-value:2.04E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.00|P-value:9.13E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.13|P-value:5.64E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.44|P-value:1.72E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-4.02|P-value:1.59E-5 ID:SGTC_3273|Compound:9137859|FD-Score:-4.11|P-value:1.06E-5

Top fitness defect scores for YIR007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 6.92 42.5 µM 3.30E-13 5 2.22E-12
2 SGTC_2804 7954240 5.63 19.5 µM 2.47E-9 5 8.92E-9
3 SGTC_2366 9070441 5.05 60.6 µM 7.71E-8 10 2.19E-7
4 SGTC_440 fluspirilene 4.47 35.1 µM 1.66E-6 6 3.82E-6
5 SGTC_542 3381-0244 4.39 89.3 µM 2.59E-6 28 5.79E-6
6 SGTC_1346 1488-2224 4.16 62.4 µM 7.57E-6 18 1.57E-5
7 SGTC_2017 5132927 4.11 60.6 µM 9.69E-6 30 1.97E-5
8 SGTC_1641 st009299 3.78 47.1 µM 4.22E-5 mitochondrial processes 10 7.76E-5
9 SGTC_2094 5332512 3.48 191.7 µM 1.48E-4 37 2.51E-4
10 SGTC_1343 1487-0095 3.45 224.0 µM 1.66E-4 16 2.78E-4
11 SGTC_3262 9137218 3.44 49.5 µM 1.72E-4 7 2.87E-4
12 SGTC_2087 5276107 3.31 200.0 µM 2.84E-4 33 4.59E-4
13 SGTC_1521 st012942 3.28 49.4 µM 3.24E-4 61 5.19E-4
14 SGTC_886 0866-0150 3.22 153.0 µM 4.03E-4 48 6.37E-4
15 SGTC_3083 9117465 3.13 49.5 µM 5.64E-4 60 8.71E-4
16 SGTC_2814 7977482 3.00 43.0 µM 9.13E-4 110 0.00136
17 SGTC_619 1652-1634 2.98 108.0 µM 9.54E-4 PDR1 62 0.00142
18 SGTC_2797 7859098 2.97 81.8 µM 9.88E-4 76 0.00147
19 SGTC_358 0075-0058 2.96 9.4 µM 0.00105 135 0.00156
20 SGTC_353 1988-1175 2.93 58.3 µM 0.00116 unfolded protein response 73 0.00170

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 7.17E-24 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.142 1.73E-16 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
0.133 1.03E-14 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.126 2.39E-13 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.107 4.23E-10 YLR278C_p YLR278C_p hom Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
0.106 8.08E-10 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.105 1.24E-9 YCR020C-A MAK31 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
0.104 1.54E-9 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.097 1.62E-8 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.097 1.94E-8 YLR403W SFP1 hom Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
0.096 2.58E-8 YGL038C OCH1 hom Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
0.096 2.73E-8 YKR081C RPF2 het Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
0.092 8.55E-8 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.089 2.14E-7 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.088 2.98E-7 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1