YIR008C / PRI1

Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIR008C / PRI1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.38|P-value:9.10E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:5.15|P-value:4.34E-9 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.05|P-value:3.76E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.84|P-value:8.64E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.18|P-value:1.90E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.28|P-value:1.45E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:19.40|P-value:9.70E-104 ID:SGTC_168|Compound:3970-0862|FD-Score:4.68|P-value:8.77E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:4.00|P-value:3.83E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:5.21|P-value:2.97E-9 ID:SGTC_214|Compound:4373-3496|FD-Score:3.31|P-value:1.06E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:7.70|P-value:4.64E-18 ID:SGTC_400|Compound:oxethazaine|FD-Score:-4.18|P-value:1.81E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.29|P-value:1.18E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.95|P-value:4.72E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.39|P-value:7.37E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.33|P-value:9.81E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.79|P-value:4.38E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:7.56|P-value:1.64E-17 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.83|P-value:9.32E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.66|P-value:2.09E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.10|P-value:2.60E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.11|P-value:2.46E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.28|P-value:1.45E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.93|P-value:5.21E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.17|P-value:1.92E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.93|P-value:5.24E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:2.76|P-value:9.99E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:2.79|P-value:9.06E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.11|P-value:2.93E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-2.81|P-value:9.58E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.58|P-value:3.06E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.15|P-value:2.14E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.09|P-value:2.37E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.16|P-value:2.07E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.04|P-value:3.84E-4 ID:SGTC_2085|Compound:5307070|FD-Score:2.84|P-value:7.43E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.71|P-value:1.72E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.79|P-value:1.15E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.03|P-value:3.32E-6 ID:SGTC_2401|Compound:5128683|FD-Score:3.52|P-value:4.04E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.79|P-value:4.42E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.43|P-value:6.61E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:3.09|P-value:2.75E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.84|P-value:9.01E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.70|P-value:2.23E-39 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.96|P-value:4.90E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.55|P-value:3.52E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.61|P-value:2.69E-5 ID:SGTC_2799|Compound:7812892|FD-Score:2.77|P-value:9.61E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-2.80|P-value:9.74E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.86|P-value:9.63E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.25|P-value:1.36E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-5.60|P-value:2.73E-10 ID:SGTC_2975|Compound:9084847|FD-Score:3.47|P-value:5.19E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.42|P-value:6.65E-5 ID:SGTC_3132|Compound:9126706|FD-Score:4.85|P-value:3.09E-8 ID:SGTC_3153|Compound:9100258|FD-Score:4.53|P-value:2.07E-7 ID:SGTC_3157|Compound:9099274|FD-Score:4.30|P-value:7.95E-7 ID:SGTC_3243|Compound:9134147|FD-Score:3.35|P-value:8.99E-5 ID:SGTC_3278|Compound:9139605|FD-Score:-5.13|P-value:6.46E-9 ID:SGTC_3279|Compound:9140807|FD-Score:-4.58|P-value:1.98E-7 ID:SGTC_3292|Compound:9120825|FD-Score:3.23|P-value:1.50E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.35|P-value:9.08E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.38|P-value:9.10E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:5.15|P-value:4.34E-9 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.05|P-value:3.76E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.84|P-value:8.64E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.18|P-value:1.90E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.28|P-value:1.45E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:19.40|P-value:9.70E-104 ID:SGTC_168|Compound:3970-0862|FD-Score:4.68|P-value:8.77E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:4.00|P-value:3.83E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:5.21|P-value:2.97E-9 ID:SGTC_214|Compound:4373-3496|FD-Score:3.31|P-value:1.06E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:7.70|P-value:4.64E-18 ID:SGTC_400|Compound:oxethazaine|FD-Score:-4.18|P-value:1.81E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.29|P-value:1.18E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.95|P-value:4.72E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.39|P-value:7.37E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:3.33|P-value:9.81E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.79|P-value:4.38E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:7.56|P-value:1.64E-17 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.83|P-value:9.32E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.66|P-value:2.09E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.10|P-value:2.60E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.11|P-value:2.46E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.28|P-value:1.45E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:2.93|P-value:5.21E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.17|P-value:1.92E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.93|P-value:5.24E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:2.76|P-value:9.99E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:2.79|P-value:9.06E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.11|P-value:2.93E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-2.81|P-value:9.58E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.58|P-value:3.06E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.15|P-value:2.14E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.09|P-value:2.37E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.16|P-value:2.07E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.04|P-value:3.84E-4 ID:SGTC_2085|Compound:5307070|FD-Score:2.84|P-value:7.43E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.71|P-value:1.72E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.79|P-value:1.15E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.03|P-value:3.32E-6 ID:SGTC_2401|Compound:5128683|FD-Score:3.52|P-value:4.04E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.79|P-value:4.42E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.43|P-value:6.61E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:3.09|P-value:2.75E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.84|P-value:9.01E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.70|P-value:2.23E-39 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.96|P-value:4.90E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.55|P-value:3.52E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.61|P-value:2.69E-5 ID:SGTC_2799|Compound:7812892|FD-Score:2.77|P-value:9.61E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-2.80|P-value:9.74E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.86|P-value:9.63E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.25|P-value:1.36E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-5.60|P-value:2.73E-10 ID:SGTC_2975|Compound:9084847|FD-Score:3.47|P-value:5.19E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.42|P-value:6.65E-5 ID:SGTC_3132|Compound:9126706|FD-Score:4.85|P-value:3.09E-8 ID:SGTC_3153|Compound:9100258|FD-Score:4.53|P-value:2.07E-7 ID:SGTC_3157|Compound:9099274|FD-Score:4.30|P-value:7.95E-7 ID:SGTC_3243|Compound:9134147|FD-Score:3.35|P-value:8.99E-5 ID:SGTC_3278|Compound:9139605|FD-Score:-5.13|P-value:6.46E-9 ID:SGTC_3279|Compound:9140807|FD-Score:-4.58|P-value:1.98E-7 ID:SGTC_3292|Compound:9120825|FD-Score:3.23|P-value:1.50E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.35|P-value:9.08E-5

Top fitness defect scores for YIR008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 19.40 7.5 µM 9.70E-104 4 4.15E-84 6.23
2 SGTC_2651 1327-0036 11.70 5.0 µM 2.23E-39 12 4.10E-32 1.07
3 SGTC_266 formosanin C 7.70 406.0 nM 4.64E-18 sphingolipid biosynthesis & PDR1 4 6.98E-15 0.81
4 SGTC_514 4466-0038 7.56 2.6 nM 1.64E-17 cell wall 7 1.94E-14 0.25
5 SGTC_2582 agaric acid 5.43 100.0 µM 6.61E-10 redox potentiating 19 2.77E-8 0.03
6 SGTC_184 1494-0393 5.21 24.7 µM 2.97E-9 14 9.34E-8 0.07
7 SGTC_81 0411-0046 5.15 10.0 µM 4.34E-9 26 1.27E-7 0.02
8 SGTC_3132 9126706 4.85 49.5 µM 3.09E-8 4 6.24E-7 0.19
9 SGTC_513 4245-1575 4.79 41.7 µM 4.38E-8 unfolded protein response 20 8.28E-7 0.10
10 SGTC_2567 aureobasidin a 4.79 60.0 nM 4.42E-8 31 8.35E-7 0.08
11 SGTC_168 3970-0862 4.68 530.5 µM 8.77E-8 32 1.45E-6 0.06
12 SGTC_3153 9100258 4.53 49.5 µM 2.07E-7 2 2.92E-6 0.44
13 SGTC_3157 9099274 4.30 49.5 µM 7.95E-7 5 8.70E-6 0.60
14 SGTC_1917 st066507 4.09 28.5 µM 2.37E-6 Golgi 6 2.11E-5 0.04
15 SGTC_2396 5342950 4.03 42.8 µM 3.32E-6 RSC complex & mRNA processing 33 2.78E-5 0.01
16 SGTC_173 1273-0061 4.00 2.7 µM 3.83E-6 mitochondrial stress 26 3.12E-5 0.13
17 SGTC_2688 kanamycin b 3.96 96.7 µM 4.90E-6 calcium & mitochondrial duress 20 3.81E-5 0.01
18 SGTC_2595 hexamethylquercetagetin 3.84 100.0 µM 9.01E-6 6 6.25E-5 0.08
19 SGTC_546 peri-Naphthalide 3.83 147.0 µM 9.32E-6 DNA damage response 28 6.43E-5 0.01
20 SGTC_2395 5646831 3.79 180.2 µM 1.15E-5 3 7.62E-5 0.21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.558 1.87E-274 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.484 9.86E-197 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.448 1.47E-165 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.430 7.48E-151 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.414 3.73E-139 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.402 3.16E-130 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.385 3.44E-119 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.363 4.86E-105 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.356 1.22E-100 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.342 1.32E-92 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.341 9.22E-92 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.322 6.02E-82 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.322 6.99E-82 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.310 1.92E-75 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.274 6.21E-59 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex