YIR012W / SQT1

Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIR012W / SQT1

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:5.31|P-value:1.02E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:2.82|P-value:6.69E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.48|P-value:3.95E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.79|P-value:8.71E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:11.70|P-value:1.22E-39 ID:SGTC_168|Compound:3970-0862|FD-Score:3.95|P-value:3.94E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:2.88|P-value:5.32E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.36|P-value:4.06E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:3.77|P-value:9.57E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.03|P-value:4.13E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:2.21E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.20|P-value:9.80E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.13|P-value:2.23E-12 ID:SGTC_435|Compound:c-PAF|FD-Score:8.62|P-value:1.34E-22 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-2.84|P-value:8.73E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.15|P-value:1.75E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:2.81|P-value:6.98E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.87|P-value:5.51E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.88|P-value:5.41E-6 ID:SGTC_600|Compound:1495-0418|FD-Score:-2.93|P-value:6.12E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.21|P-value:1.54E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.01|P-value:4.38E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.23|P-value:1.24E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.59|P-value:2.30E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.26|P-value:1.08E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-2.93|P-value:6.15E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.54|P-value:2.99E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.16|P-value:1.27E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.44|P-value:4.78E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.52|P-value:1.59E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:2.90|P-value:4.84E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.83|P-value:1.12E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.86|P-value:7.92E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.13|P-value:2.75E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.05|P-value:2.67E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.39|P-value:8.69E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.85|P-value:5.89E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:2.78|P-value:7.69E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:2.76|P-value:8.30E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.08|P-value:2.35E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.34|P-value:7.25E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.71|P-value:5.72E-11 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.73|P-value:1.79E-5 ID:SGTC_1686|Compound:st019653|FD-Score:3.02|P-value:3.05E-4 ID:SGTC_1699|Compound:st031318|FD-Score:-4.15|P-value:2.11E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.26|P-value:1.07E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.89|P-value:5.21E-6 ID:SGTC_2189|Compound:6047310|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.36|P-value:6.96E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.71|P-value:1.28E-5 ID:SGTC_2436|Compound:5633522|FD-Score:-2.98|P-value:4.93E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.05|P-value:3.81E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.16|P-value:1.89E-12 ID:SGTC_2605|Compound:digitonin|FD-Score:2.85|P-value:5.98E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.00|P-value:1.17E-29 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.71|P-value:4.90E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.30|P-value:5.65E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.09|P-value:2.28E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.75|P-value:8.84E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.75|P-value:1.07E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.49|P-value:3.83E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-2.86|P-value:7.89E-4 ID:SGTC_2886|Compound:9058944|FD-Score:2.86|P-value:5.63E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.18|P-value:1.49E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.81|P-value:6.99E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-2.97|P-value:5.24E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-2.92|P-value:6.26E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.59|P-value:3.58E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.24|P-value:1.74E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.83|P-value:6.33E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.89|P-value:8.18E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.01|P-value:3.09E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:5.31|P-value:1.02E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:2.82|P-value:6.69E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.48|P-value:3.95E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.79|P-value:8.71E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:11.70|P-value:1.22E-39 ID:SGTC_168|Compound:3970-0862|FD-Score:3.95|P-value:3.94E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:2.88|P-value:5.32E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.36|P-value:4.06E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:3.77|P-value:9.57E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.03|P-value:4.13E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:2.21E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.20|P-value:9.80E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.13|P-value:2.23E-12 ID:SGTC_435|Compound:c-PAF|FD-Score:8.62|P-value:1.34E-22 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-2.84|P-value:8.73E-4 ID:SGTC_462|Compound:ag-879|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.15|P-value:1.75E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:2.81|P-value:6.98E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.87|P-value:5.51E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.88|P-value:5.41E-6 ID:SGTC_600|Compound:1495-0418|FD-Score:-2.93|P-value:6.12E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.21|P-value:1.54E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.01|P-value:4.38E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.23|P-value:1.24E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.59|P-value:2.30E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.26|P-value:1.08E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-2.93|P-value:6.15E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.54|P-value:2.99E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.16|P-value:1.27E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.44|P-value:4.78E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.52|P-value:1.59E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:2.90|P-value:4.84E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.83|P-value:1.12E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.86|P-value:7.92E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.13|P-value:2.75E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.05|P-value:2.67E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.39|P-value:8.69E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:2.85|P-value:5.89E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:2.78|P-value:7.69E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:2.76|P-value:8.30E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.08|P-value:2.35E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.34|P-value:7.25E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.71|P-value:5.72E-11 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.73|P-value:1.79E-5 ID:SGTC_1686|Compound:st019653|FD-Score:3.02|P-value:3.05E-4 ID:SGTC_1699|Compound:st031318|FD-Score:-4.15|P-value:2.11E-6 ID:SGTC_2114|Compound:5491910|FD-Score:3.26|P-value:1.07E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.89|P-value:5.21E-6 ID:SGTC_2189|Compound:6047310|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.36|P-value:6.96E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.71|P-value:1.28E-5 ID:SGTC_2436|Compound:5633522|FD-Score:-2.98|P-value:4.93E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.05|P-value:3.81E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.16|P-value:1.89E-12 ID:SGTC_2605|Compound:digitonin|FD-Score:2.85|P-value:5.98E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.00|P-value:1.17E-29 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.71|P-value:4.90E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.30|P-value:5.65E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.09|P-value:2.28E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.75|P-value:8.84E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.75|P-value:1.07E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.49|P-value:3.83E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-2.86|P-value:7.89E-4 ID:SGTC_2886|Compound:9058944|FD-Score:2.86|P-value:5.63E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.18|P-value:1.49E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.81|P-value:6.99E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-2.97|P-value:5.24E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-2.92|P-value:6.26E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.59|P-value:3.58E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.24|P-value:1.74E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.83|P-value:6.33E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.89|P-value:8.18E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.01|P-value:3.09E-4

Top fitness defect scores for YIR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 11.70 7.5 µM 1.22E-39 10 9.22E-32 0.23
2 SGTC_2651 1327-0036 10.00 5.0 µM 1.17E-29 16 7.87E-24 0.39
3 SGTC_435 c-PAF 8.62 6.7 µM 1.34E-22 1 3.21E-18 1.37
4 SGTC_2582 agaric acid 6.16 100.0 µM 1.89E-12 redox potentiating 15 3.74E-10 0.25
5 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 6.13 8.0 µM 2.23E-12 7 4.26E-10 1.36
6 SGTC_1680 diphenhydramine 5.71 100.0 µM 5.72E-11 NEO1 3 5.62E-9 0.04
7 SGTC_81 0411-0046 5.31 10.0 µM 1.02E-9 24 5.54E-8 0.12
8 SGTC_2688 kanamycin b 4.71 96.7 µM 4.90E-8 calcium & mitochondrial duress 8 1.21E-6 0.02
9 SGTC_1069 diphenylcyclopropenone 4.52 8.5 µM 1.59E-7 5 3.09E-6 0.23
10 SGTC_266 formosanin C 4.36 406.0 nM 4.06E-7 sphingolipid biosynthesis & PDR1 21 6.51E-6 0.11
11 SGTC_2689 tacrolimus 4.30 100.0 µM 5.65E-7 10 8.49E-6 0.09
12 SGTC_417 st075190 4.20 100.0 µM 9.80E-7 1 1.32E-5 0.65
13 SGTC_966 1300-0360 4.16 30.2 µM 1.27E-6 heme requiring 14 1.62E-5 0.10
14 SGTC_168 3970-0862 3.95 530.5 µM 3.94E-6 45 3.98E-5 0.03
15 SGTC_2139 5578692 3.89 56.5 µM 5.21E-6 superoxide 16 4.98E-5 0.05
16 SGTC_570 0987-0065 3.88 62.6 µM 5.41E-6 60S ribosome export 6 5.13E-5 0.40
17 SGTC_150 3970-0969 3.79 77.2 µM 8.71E-6 19 7.50E-5 0.06
18 SGTC_309 k408-0051 3.77 1.5 µM 9.57E-6 27 8.08E-5 0.02
19 SGTC_2790 5423970 3.75 71.4 µM 1.07E-5 endomembrane recycling 20 8.81E-5 0.14
20 SGTC_2396 5342950 3.71 42.8 µM 1.28E-5 RSC complex & mRNA processing 40 1.02E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.457 3.50E-173 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.456 5.28E-172 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.448 1.47E-165 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.446 1.81E-163 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.435 5.65E-155 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.383 7.65E-118 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.369 1.38E-108 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.362 1.09E-104 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.325 1.44E-83 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.280 1.19E-61 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.270 3.39E-57 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.270 4.95E-57 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.263 5.37E-54 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.256 2.49E-51 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.252 1.04E-49 YIL061C SNP1 het Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress