YIR013C / GAT4

Protein containing GATA family zinc finger motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR013C / GAT4

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:2.75|P-value:8.15E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.90|P-value:4.35E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.47|P-value:3.39E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:2.77|P-value:7.52E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-2.81|P-value:6.41E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:2.74|P-value:8.49E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.36|P-value:5.86E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.80|P-value:6.51E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:2.79|P-value:7.02E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.78|P-value:7.30E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-2.85|P-value:5.36E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.04|P-value:2.45E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.11|P-value:1.85E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.17|P-value:1.42E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.12|P-value:1.77E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.60|P-value:1.87E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.87|P-value:5.05E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.81|P-value:6.48E-4 ID:SGTC_1704|Compound:st028805|FD-Score:2.72|P-value:9.18E-4 ID:SGTC_1752|Compound:st044819|FD-Score:2.89|P-value:4.69E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.90|P-value:4.51E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-2.92|P-value:4.09E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-3.22|P-value:1.11E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.82|P-value:6.00E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.82|P-value:6.09E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:6.83|P-value:2.43E-15 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.06|P-value:1.61E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.59|P-value:1.92E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.11|P-value:1.82E-4 ID:SGTC_3071|Compound:9117417|FD-Score:2.79|P-value:6.99E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:2.75|P-value:8.15E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.90|P-value:4.35E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.47|P-value:3.39E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:2.77|P-value:7.52E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-2.81|P-value:6.41E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:2.74|P-value:8.49E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.36|P-value:5.86E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.80|P-value:6.51E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:2.79|P-value:7.02E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.78|P-value:7.30E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-2.85|P-value:5.36E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.04|P-value:2.45E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-3.11|P-value:1.85E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.17|P-value:1.42E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.12|P-value:1.77E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.60|P-value:1.87E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.87|P-value:5.05E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.81|P-value:6.48E-4 ID:SGTC_1704|Compound:st028805|FD-Score:2.72|P-value:9.18E-4 ID:SGTC_1752|Compound:st044819|FD-Score:2.89|P-value:4.69E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.90|P-value:4.51E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-2.92|P-value:4.09E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-3.22|P-value:1.11E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.82|P-value:6.00E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.82|P-value:6.09E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:6.83|P-value:2.43E-15 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.06|P-value:1.61E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.59|P-value:1.92E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.11|P-value:1.82E-4 ID:SGTC_3071|Compound:9117417|FD-Score:2.79|P-value:6.99E-4

Top fitness defect scores for YIR013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2598 perillyl alcohol 6.83 100.0 µM 2.43E-15 4 4.26E-12
2 SGTC_1388 3346-4487 3.78 254.0 µM 7.30E-6 32 7.83E-5
3 SGTC_2809 7964133 3.59 13.0 µM 1.92E-5 60S ribosome export 51 1.65E-4
4 SGTC_619 1652-1634 3.47 108.0 µM 3.39E-5 PDR1 31 2.56E-4
5 SGTC_1124 fisetin 3.36 1.2 µM 5.86E-5 58 3.91E-4
6 SGTC_2970 9090938 3.11 41.9 µM 1.82E-4 RNA processing & uracil transport 96 9.39E-4
7 SGTC_358 0075-0058 2.90 9.4 µM 4.35E-4 142 0.00185
8 SGTC_1752 st044819 2.89 83.0 µM 4.69E-4 75 0.00196
9 SGTC_2163 5671233 2.82 125.0 µM 6.00E-4 88 0.00237
10 SGTC_2594 a-mangostin 2.82 100.0 µM 6.09E-4 89 0.00239
11 SGTC_1601 4'-hydroxyflavanone 2.81 55.5 µM 6.48E-4 RPP1 & pyrimidine depletion 91 0.00251
12 SGTC_1306 1185-0270 2.80 9.0 µM 6.51E-4 Golgi 106 0.00252
13 SGTC_3071 9117417 2.79 49.5 µM 6.99E-4 fatty acid desaturase (OLE1) 57 0.00266
14 SGTC_1314 1222-0010 2.79 41.1 µM 7.02E-4 53 0.00267
15 SGTC_655 k060-0012 2.77 42.0 µM 7.52E-4 69 0.00282
16 SGTC_64 000l-0018 2.75 272.1 µM 8.15E-4 ubiquinone biosynthesis & proteasome 239 0.00300
17 SGTC_979 1426-2828 2.74 121.0 µM 8.49E-4 97 0.00310
18 SGTC_1704 st028805 2.72 70.8 µM 9.18E-4 59 0.00330
19 SGTC_1650 st011916 2.67 45.8 µM 0.00109 60 0.00376
20 SGTC_1411 3909-8223 2.67 150.0 µM 0.00112 61 0.00383

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.45E-33 YPL130W SPO19 hom Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation
0.152 7.86E-19 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.137 2.23E-15 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.135 3.84E-15 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
0.132 2.00E-14 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.132 2.01E-14 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.131 3.21E-14 YER097W_d YER097W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 1.87E-12 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.120 3.67E-12 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.119 4.45E-12 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.119 4.61E-12 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.112 8.26E-11 YKL192C ACP1 het Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
0.111 1.28E-10 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.111 1.49E-10 YGR141W VPS62 hom Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
0.110 1.89E-10 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit