YIR019C / FLO11

GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR019C / FLO11

Click on Significant Values for Screen Details ID:SGTC_237|Compound:nikkomycin|FD-Score:2.88|P-value:8.97E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.98|P-value:8.13E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.95|P-value:4.54E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.44|P-value:9.92E-5 ID:SGTC_389|Compound:tpck|FD-Score:-4.85|P-value:7.92E-8 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-6.22|P-value:8.91E-12 ID:SGTC_393|Compound:acivicin|FD-Score:5.71|P-value:3.13E-10 ID:SGTC_523|Compound:1934-0222|FD-Score:2.92|P-value:7.80E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.82|P-value:1.77E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:2.99|P-value:6.03E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.87|P-value:1.37E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:5.04|P-value:2.47E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:4.07|P-value:5.29E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.90|P-value:1.19E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.11|P-value:3.75E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.01|P-value:7.15E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.05|P-value:5.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.92|P-value:1.07E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:2.99|P-value:6.09E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.04|P-value:4.98E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.61|P-value:2.93E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.71|P-value:2.92E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.98|P-value:6.48E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:2.99|P-value:5.90E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.80|P-value:1.91E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.12|P-value:4.06E-6 ID:SGTC_1619|Compound:st003326|FD-Score:2.98|P-value:6.33E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.27|P-value:1.97E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.94|P-value:7.54E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.45|P-value:9.47E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.38|P-value:1.32E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.04|P-value:5.13E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.11|P-value:3.96E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.07|P-value:4.51E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.75|P-value:2.51E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.28|P-value:1.89E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-4.08|P-value:5.23E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.42|P-value:1.09E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.84|P-value:8.21E-8 ID:SGTC_2310|Compound:7668677|FD-Score:3.48|P-value:8.09E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.07|P-value:4.49E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.12|P-value:3.68E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.77|P-value:2.18E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.33|P-value:1.57E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.60|P-value:4.85E-5 ID:SGTC_2483|Compound:5729050|FD-Score:6.01|P-value:3.87E-11 ID:SGTC_2525|Compound:harmine|FD-Score:3.32|P-value:1.64E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.15|P-value:3.23E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.29|P-value:1.80E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.93|P-value:7.89E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.49|P-value:7.93E-5 ID:SGTC_2781|Compound:5567276|FD-Score:2.96|P-value:6.69E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.45|P-value:7.32E-7 ID:SGTC_2792|Compound:7535235|FD-Score:6.61|P-value:4.11E-13 ID:SGTC_2797|Compound:7859098|FD-Score:4.74|P-value:1.48E-7 ID:SGTC_2801|Compound:7907800|FD-Score:-3.44|P-value:1.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.07|P-value:4.42E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.46|P-value:8.83E-5 ID:SGTC_2938|Compound:9059746|FD-Score:3.08|P-value:4.24E-4 ID:SGTC_2994|Compound:9053520|FD-Score:6.63|P-value:3.52E-13 ID:SGTC_3319|Compound:9138450|FD-Score:3.44|P-value:9.66E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-2.94|P-value:7.46E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:2.88|P-value:8.97E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.98|P-value:8.13E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.95|P-value:4.54E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.44|P-value:9.92E-5 ID:SGTC_389|Compound:tpck|FD-Score:-4.85|P-value:7.92E-8 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-6.22|P-value:8.91E-12 ID:SGTC_393|Compound:acivicin|FD-Score:5.71|P-value:3.13E-10 ID:SGTC_523|Compound:1934-0222|FD-Score:2.92|P-value:7.80E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.82|P-value:1.77E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:2.99|P-value:6.03E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.87|P-value:1.37E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:5.04|P-value:2.47E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:4.07|P-value:5.29E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.90|P-value:1.19E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.11|P-value:3.75E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:2.87|P-value:9.36E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.01|P-value:7.15E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.05|P-value:5.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.92|P-value:1.07E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:2.99|P-value:6.09E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.04|P-value:4.98E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.61|P-value:2.93E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.71|P-value:2.92E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.98|P-value:6.48E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:2.99|P-value:5.90E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.80|P-value:1.91E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.12|P-value:4.06E-6 ID:SGTC_1619|Compound:st003326|FD-Score:2.98|P-value:6.33E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.27|P-value:1.97E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.94|P-value:7.54E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.45|P-value:9.47E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.38|P-value:1.32E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.04|P-value:5.13E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.11|P-value:3.96E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.07|P-value:4.51E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.75|P-value:2.51E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.28|P-value:1.89E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-4.08|P-value:5.23E-6 ID:SGTC_2134|Compound:5324836|FD-Score:-3.42|P-value:1.09E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.84|P-value:8.21E-8 ID:SGTC_2310|Compound:7668677|FD-Score:3.48|P-value:8.09E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.07|P-value:4.49E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.12|P-value:3.68E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.77|P-value:2.18E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.33|P-value:1.57E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.60|P-value:4.85E-5 ID:SGTC_2483|Compound:5729050|FD-Score:6.01|P-value:3.87E-11 ID:SGTC_2525|Compound:harmine|FD-Score:3.32|P-value:1.64E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.15|P-value:3.23E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.29|P-value:1.80E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.93|P-value:7.89E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.49|P-value:7.93E-5 ID:SGTC_2781|Compound:5567276|FD-Score:2.96|P-value:6.69E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.45|P-value:7.32E-7 ID:SGTC_2792|Compound:7535235|FD-Score:6.61|P-value:4.11E-13 ID:SGTC_2797|Compound:7859098|FD-Score:4.74|P-value:1.48E-7 ID:SGTC_2801|Compound:7907800|FD-Score:-3.44|P-value:1.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.07|P-value:4.42E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.46|P-value:8.83E-5 ID:SGTC_2938|Compound:9059746|FD-Score:3.08|P-value:4.24E-4 ID:SGTC_2994|Compound:9053520|FD-Score:6.63|P-value:3.52E-13 ID:SGTC_3319|Compound:9138450|FD-Score:3.44|P-value:9.66E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-2.94|P-value:7.46E-4

Top fitness defect scores for YIR019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2994 9053520 6.63 71.4 µM 3.52E-13 RPP1 & pyrimidine depletion 3 1.65E-11
2 SGTC_2792 7535235 6.61 81.8 µM 4.11E-13 fatty acid desaturase (OLE1) 7 1.88E-11
3 SGTC_2483 5729050 6.01 27.2 µM 3.87E-11 6 9.26E-10
4 SGTC_393 acivicin 5.71 6.2 µM 3.13E-10 7 5.56E-9
5 SGTC_673 1082-0474 5.04 110.0 µM 2.47E-8 RSC complex & mRNA processing 35 2.35E-7
6 SGTC_2282 7944268 4.84 200.0 µM 8.21E-8 RPP1 & pyrimidine depletion 13 6.61E-7
7 SGTC_2797 7859098 4.74 81.8 µM 1.48E-7 15 1.09E-6
8 SGTC_1132 3456-3614 4.61 2.5 µM 2.93E-7 tubulin folding & SWR complex 23 1.97E-6
9 SGTC_2785 7756463 4.45 72.7 µM 7.32E-7 16 4.33E-6
10 SGTC_1562 morin hydrate 4.12 59.1 µM 4.06E-6 13 1.89E-5
11 SGTC_697 0508-1955 4.07 564.0 µM 5.29E-6 30 2.37E-5
12 SGTC_753 1322-0200 4.01 289.0 µM 7.15E-6 17 3.07E-5
13 SGTC_271 rotenone 3.98 740.0 µM 8.13E-6 22 3.43E-5
14 SGTC_784 4579-0127 3.92 173.0 µM 1.07E-5 22 4.34E-5
15 SGTC_699 0375-0592 3.90 111.0 µM 1.19E-5 iron homeostasis 20 4.75E-5
16 SGTC_639 0833-0042 3.87 114.0 µM 1.37E-5 47 5.37E-5
17 SGTC_598 3937-0236 3.82 20.2 µM 1.77E-5 ERG2 29 6.69E-5
18 SGTC_1502 4534-4282 3.80 27.7 µM 1.91E-5 15 7.15E-5
19 SGTC_2447 5741742 3.77 33.8 µM 2.18E-5 26 8.01E-5
20 SGTC_1377 2944-0135 3.71 198.0 µM 2.92E-5 calcium & mitochondrial duress 46 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.17E-11 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.107 4.48E-10 YBR113W_d YBR113W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
0.107 4.78E-10 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.105 1.08E-9 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.103 2.05E-9 YJR103W URA8 hom Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
0.093 7.51E-8 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.086 5.37E-7 YIL095W PRK1 hom Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication
0.083 1.34E-6 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
0.083 1.60E-6 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.083 1.71E-6 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.082 2.27E-6 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.081 3.01E-6 YOR226C ISU2 hom Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved
0.080 3.95E-6 YER179W DMC1 hom Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p
0.079 5.04E-6 YER168C CCA1 het ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.079 5.24E-6 YOR347C PYK2 hom Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication