YIR020C_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR020C / YIR020C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.23|P-value:1.76E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.31|P-value:9.70E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.39|P-value:6.96E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:2.87|P-value:6.23E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.06|P-value:2.84E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-2.83|P-value:8.62E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.48|P-value:5.70E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.36|P-value:7.98E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:6.22|P-value:1.65E-12 ID:SGTC_551|Compound:k048-0028|FD-Score:4.25|P-value:9.32E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:3.79|P-value:1.03E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.49|P-value:4.36E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.12|P-value:2.74E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:2.96|P-value:4.39E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.08|P-value:2.61E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.11|P-value:2.88E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.74|P-value:1.69E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.33|P-value:8.03E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.80|P-value:3.71E-8 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.17|P-value:2.23E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:2.83|P-value:7.16E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.06|P-value:2.89E-4 ID:SGTC_1756|Compound:st041558|FD-Score:2.93|P-value:4.85E-4 ID:SGTC_1790|Compound:st045711|FD-Score:2.88|P-value:6.01E-4 ID:SGTC_1829|Compound:berberine|FD-Score:5.80|P-value:3.89E-11 ID:SGTC_1841|Compound:st054148|FD-Score:2.86|P-value:6.46E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:6.33|P-value:6.69E-13 ID:SGTC_1892|Compound:st058411|FD-Score:5.32|P-value:1.18E-9 ID:SGTC_1903|Compound:st060211|FD-Score:4.95|P-value:1.43E-8 ID:SGTC_1906|Compound:st060206|FD-Score:3.30|P-value:1.03E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.12|P-value:2.21E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.26|P-value:1.22E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.94|P-value:4.85E-6 ID:SGTC_2067|Compound:5224629|FD-Score:4.19|P-value:1.28E-6 ID:SGTC_2073|Compound:5212005|FD-Score:2.88|P-value:6.02E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.91|P-value:5.22E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.18|P-value:1.36E-6 ID:SGTC_2271|Compound:7849410|FD-Score:2.83|P-value:7.08E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.55|P-value:3.37E-5 ID:SGTC_2273|Compound:7815444|FD-Score:4.95|P-value:1.46E-8 ID:SGTC_2283|Compound:7944793|FD-Score:-3.72|P-value:1.89E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.91|P-value:6.42E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-3.55|P-value:4.11E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.62|P-value:1.11E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.97|P-value:5.01E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.00|P-value:4.57E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-2.85|P-value:8.18E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.30|P-value:1.31E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.64|P-value:2.14E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-2.89|P-value:6.91E-4 ID:SGTC_2938|Compound:9059746|FD-Score:5.76|P-value:5.45E-11 ID:SGTC_3117|Compound:9124945|FD-Score:-3.13|P-value:2.64E-4 ID:SGTC_3306|Compound:9127676|FD-Score:4.10|P-value:2.04E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.23|P-value:1.76E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.31|P-value:9.70E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.39|P-value:6.96E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:2.87|P-value:6.23E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.06|P-value:2.84E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-2.83|P-value:8.62E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.48|P-value:5.70E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.36|P-value:7.98E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:6.22|P-value:1.65E-12 ID:SGTC_551|Compound:k048-0028|FD-Score:4.25|P-value:9.32E-7 ID:SGTC_566|Compound:0958-0068|FD-Score:3.79|P-value:1.03E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.49|P-value:4.36E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.12|P-value:2.74E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:2.96|P-value:4.39E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.08|P-value:2.61E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.11|P-value:2.88E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.74|P-value:1.69E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.33|P-value:8.03E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.80|P-value:3.71E-8 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.17|P-value:2.23E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:2.83|P-value:7.16E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.06|P-value:2.89E-4 ID:SGTC_1756|Compound:st041558|FD-Score:2.93|P-value:4.85E-4 ID:SGTC_1790|Compound:st045711|FD-Score:2.88|P-value:6.01E-4 ID:SGTC_1829|Compound:berberine|FD-Score:5.80|P-value:3.89E-11 ID:SGTC_1841|Compound:st054148|FD-Score:2.86|P-value:6.46E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:6.33|P-value:6.69E-13 ID:SGTC_1892|Compound:st058411|FD-Score:5.32|P-value:1.18E-9 ID:SGTC_1903|Compound:st060211|FD-Score:4.95|P-value:1.43E-8 ID:SGTC_1906|Compound:st060206|FD-Score:3.30|P-value:1.03E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.12|P-value:2.21E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.26|P-value:1.22E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.94|P-value:4.85E-6 ID:SGTC_2067|Compound:5224629|FD-Score:4.19|P-value:1.28E-6 ID:SGTC_2073|Compound:5212005|FD-Score:2.88|P-value:6.02E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.91|P-value:5.22E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.18|P-value:1.36E-6 ID:SGTC_2271|Compound:7849410|FD-Score:2.83|P-value:7.08E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.55|P-value:3.37E-5 ID:SGTC_2273|Compound:7815444|FD-Score:4.95|P-value:1.46E-8 ID:SGTC_2283|Compound:7944793|FD-Score:-3.72|P-value:1.89E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.91|P-value:6.42E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-3.55|P-value:4.11E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.62|P-value:1.11E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.97|P-value:5.01E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.00|P-value:4.57E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-2.85|P-value:8.18E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.30|P-value:1.31E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.64|P-value:2.14E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-2.89|P-value:6.91E-4 ID:SGTC_2938|Compound:9059746|FD-Score:5.76|P-value:5.45E-11 ID:SGTC_3117|Compound:9124945|FD-Score:-3.13|P-value:2.64E-4 ID:SGTC_3306|Compound:9127676|FD-Score:4.10|P-value:2.04E-6

Top fitness defect scores for YIR020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1888 azatryptophan 6.33 97.5 µM 6.69E-13 4 1.23E-10
2 SGTC_545 4218-0007 6.22 221.0 µM 1.65E-12 5 2.56E-10
3 SGTC_1829 berberine 5.80 14.4 µM 3.89E-11 60S ribosome export 3 3.24E-9
4 SGTC_2938 9059746 5.76 27.3 µM 5.45E-11 fatty acid desaturase (OLE1) 14 4.25E-9
5 SGTC_1892 st058411 5.32 7.4 µM 1.18E-9 7 5.05E-8
6 SGTC_1903 st060211 4.95 78.3 µM 1.43E-8 9 3.75E-7
7 SGTC_2273 7815444 4.95 169.1 µM 1.46E-8 8 3.80E-7
8 SGTC_1260 0700-1617 4.80 7.8 µM 3.71E-8 calcium & mitochondrial duress 18 8.07E-7
9 SGTC_2416 tofa 4.62 880.0 nM 1.11E-7 sphingolipid biosynthesis & PDR1 34 1.94E-6
10 SGTC_551 k048-0028 4.25 34.9 µM 9.32E-7 9 1.08E-5
11 SGTC_2067 5224629 4.19 34.1 µM 1.28E-6 20 1.40E-5
12 SGTC_2166 5933061 4.18 31.5 µM 1.36E-6 tubulin folding & SWR complex 34 1.47E-5
13 SGTC_3306 9127676 4.10 59.8 µM 2.04E-6 17 2.03E-5
14 SGTC_2055 5235184 3.94 200.0 µM 4.85E-6 ERG2 30 4.09E-5
15 SGTC_566 0958-0068 3.79 16.5 µM 1.03E-5 RSC & ERG11 20 7.53E-5
16 SGTC_2934 9036370 3.64 36.9 µM 2.14E-5 42 1.35E-4
17 SGTC_2272 7805186 3.55 180.0 µM 3.37E-5 cell wall signaling 27 1.95E-4
18 SGTC_618 k072-0232 3.49 33.2 µM 4.36E-5 60S ribosome export 18 2.41E-4
19 SGTC_319 1348-1596 3.39 45.5 µM 6.96E-5 RSC & ERG11 32 3.51E-4
20 SGTC_537 1334-0398 3.36 209.0 µM 7.98E-5 47 3.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.54E-18 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.126 2.51E-13 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.115 2.25E-11 YJR006W POL31 het Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
0.112 7.33E-11 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.106 8.00E-10 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.105 9.21E-10 YLL053C_p YLL053C_p hom Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
0.102 2.85E-9 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.100 7.24E-9 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.092 8.17E-8 YER076C_p YER076C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
0.092 8.61E-8 YHR139C-A_d YHR139C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.23E-7 YMR054W STV1 hom Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
0.088 2.85E-7 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.087 4.23E-7 YEL062W NPR2 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline
0.084 9.55E-7 YNL325C FIG4 hom Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain
0.082 1.79E-6 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene