HIPHOP chemogenomics database

YIR028W / DAL4

Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation

Zygosity: Homozygous strain

fixedexpanded
Profile for YIR028W / DAL4

Click on Significant Values for Screen Details

Top fitness defect scores for YIR028W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1783	st039459	9.50	87.5 µM	3.40E-23	Golgi	2	1.07E-21
2	SGTC_996	3970-0799	7.39	1.8 µM	9.41E-15		25	7.58E-14
3	SGTC_910	3454-3003	5.75	490.0 µM	1.22E-9		3	4.35E-9
4	SGTC_2565	isoliquiritigenin	5.40	100.0 µM	1.11E-8		13	3.39E-8
5	SGTC_2194	5927483	5.36	104.5 µM	1.39E-8		10	4.18E-8
6	SGTC_2866	9034245	5.36	58.4 µM	1.40E-8		1	4.22E-8
7	SGTC_519	k048-0011	5.04	62.8 µM	8.78E-8		7	2.33E-7
8	SGTC_3125	9127534	4.73	49.5 µM	4.81E-7		4	1.14E-6
9	SGTC_10	0279-0212	4.63	42.6 µM	7.82E-7	TRP & mitochondrial translation	82	1.79E-6
10	SGTC_1568	digitonin	4.24	820.0 nM	5.48E-6	sphingolipid biosynthesis & PDR1	26	1.10E-5
11	SGTC_2382	9035899	4.18	200.0 µM	7.40E-6	60S ribosome export	12	1.45E-5
12	SGTC_2860	9025725	3.99	39.0 µM	1.76E-5	RPP1 & pyrimidine depletion	8	3.26E-5
13	SGTC_1454	4239-0054	3.81	42.6 µM	3.97E-5		41	6.96E-5
14	SGTC_1962	st076595	3.79	64.5 µM	4.33E-5	redox potentiating	29	7.55E-5
15	SGTC_164	4100-3994	3.78	89.6 µM	4.52E-5		39	7.86E-5
16	SGTC_1245	0418-0076	3.73	17.2 µM	5.71E-5	ERG2	37	9.76E-5
17	SGTC_1494	4358-1428	3.70	177.0 µM	6.31E-5		30	1.07E-4
18	SGTC_1297	1068-0111	3.65	14.1 µM	7.79E-5		15	1.31E-4
19	SGTC_589	1227-0070	3.63	34.1 µM	8.36E-5		37	1.39E-4
20	SGTC_1846	st056244	3.61	14.8 µM	9.16E-5		41	1.52E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.229	4.15E-41	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.207	1.07E-33	YDL099W	BUG1	hom	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.162	5.35E-21	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.157	6.58E-20	YGL040C	HEM2	het	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.147	1.26E-17	YGL222C	EDC1	hom	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.144	5.60E-17	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.139	7.29E-16	YGL205W	POX1	hom	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.126	2.83E-13	YNR033W	ABZ1	hom	Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.125	3.80E-13	YBR067C	TIP1	hom	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.125	4.24E-13	YJL149W	DAS1	hom	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.121	1.94E-12	YGR035C_p	YGR035C_p	hom	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.118	6.35E-12	YGL083W	SCY1	hom	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.116	1.81E-11	YJR014W	TMA22	hom	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.116	1.96E-11	YDL186W_p	YDL186W_p	hom	Putative protein of unknown function; YDL186W is not an essential gene
0.111	1.26E-10	YGL096W	TOS8	hom	Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication