YJL019W / MPS3

Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL019W / MPS3

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:5.19|P-value:4.08E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:2.94|P-value:5.22E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.75|P-value:8.61E-8 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.84|P-value:9.19E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.95|P-value:5.76E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:3.21|P-value:1.75E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.20|P-value:1.88E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:13.10|P-value:3.05E-48 ID:SGTC_168|Compound:3970-0862|FD-Score:4.25|P-value:1.14E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:6.69|P-value:6.03E-14 ID:SGTC_214|Compound:4373-3496|FD-Score:5.00|P-value:1.43E-8 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.43|P-value:8.16E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.07|P-value:3.71E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.25|P-value:1.51E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.45|P-value:4.00E-13 ID:SGTC_291|Compound:4130-1278|FD-Score:-2.90|P-value:7.40E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.61|P-value:1.54E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:3.91|P-value:7.02E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:6.84|P-value:1.57E-14 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.78|P-value:7.24E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:4.57|P-value:1.96E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.52|P-value:2.50E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:6.02|P-value:1.23E-11 ID:SGTC_650|Compound:1328-0195|FD-Score:3.43|P-value:6.72E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.95|P-value:5.60E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.03|P-value:3.64E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:7.73|P-value:4.97E-18 ID:SGTC_743|Compound:1275-0778|FD-Score:3.93|P-value:6.08E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:3.74|P-value:1.59E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:2.91|P-value:5.85E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.11|P-value:3.15E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.91|P-value:5.84E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.60|P-value:2.63E-10 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.78|P-value:9.86E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.82|P-value:1.36E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.83|P-value:8.09E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-2.90|P-value:7.35E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-6.56|P-value:2.40E-13 ID:SGTC_1168|Compound:k815-0004|FD-Score:2.82|P-value:8.49E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-2.89|P-value:7.54E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.98|P-value:4.56E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:2.81|P-value:8.85E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.13|P-value:2.42E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.53|P-value:4.23E-10 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.62|P-value:2.82E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:3.51E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.38|P-value:8.46E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.26|P-value:1.43E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.39|P-value:7.99E-5 ID:SGTC_1620|Compound:st003704|FD-Score:-2.97|P-value:5.54E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-2.83|P-value:9.53E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.79|P-value:9.24E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.25|P-value:1.51E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.34|P-value:1.00E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.34|P-value:1.20E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.05|P-value:3.46E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.81|P-value:5.93E-8 ID:SGTC_1979|Compound:st071809|FD-Score:-5.40|P-value:1.31E-9 ID:SGTC_1984|Compound:st072354|FD-Score:-2.82|P-value:9.68E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.79|P-value:9.25E-4 ID:SGTC_1990|Compound:st072050|FD-Score:2.85|P-value:7.60E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.75|P-value:1.54E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.25|P-value:1.52E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.04|P-value:3.57E-6 ID:SGTC_2116|Compound:5511452|FD-Score:2.90|P-value:6.12E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.62|P-value:2.15E-10 ID:SGTC_2139|Compound:5578692|FD-Score:2.87|P-value:6.96E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-2.82|P-value:9.94E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.17|P-value:2.51E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.30|P-value:1.47E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.39|P-value:8.24E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-4.04|P-value:4.42E-6 ID:SGTC_2446|Compound:5162541|FD-Score:2.96|P-value:4.84E-4 ID:SGTC_2483|Compound:5729050|FD-Score:6.26|P-value:1.94E-12 ID:SGTC_2487|Compound:5918373|FD-Score:5.90|P-value:2.91E-11 ID:SGTC_2488|Compound:5268135|FD-Score:-2.88|P-value:7.95E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.04|P-value:3.57E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.14|P-value:2.06E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.80|P-value:1.46E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.07|P-value:3.19E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.82|P-value:8.55E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:24.20|P-value:6.73E-158 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.18|P-value:2.04E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:4.44E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.38|P-value:8.54E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.67|P-value:2.19E-5 ID:SGTC_2894|Compound:9048625|FD-Score:2.95|P-value:5.08E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.53|P-value:4.38E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-2.84|P-value:8.99E-4 ID:SGTC_2933|Compound:9026794|FD-Score:2.78|P-value:9.89E-4 ID:SGTC_2936|Compound:9038235|FD-Score:7.00|P-value:4.23E-15 ID:SGTC_2955|Compound:9076254|FD-Score:3.96|P-value:5.46E-6 ID:SGTC_2959|Compound:9079155|FD-Score:2.80|P-value:8.95E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.05|P-value:4.10E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.70|P-value:1.13E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-4.28|P-value:1.21E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.88|P-value:8.00E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.92|P-value:5.81E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-2.90|P-value:7.16E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-2.99|P-value:5.22E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.24|P-value:1.56E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.02|P-value:3.88E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.46|P-value:5.80E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:5.19|P-value:4.08E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:2.94|P-value:5.22E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.75|P-value:8.61E-8 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.84|P-value:9.19E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.95|P-value:5.76E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:3.21|P-value:1.75E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.20|P-value:1.88E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:13.10|P-value:3.05E-48 ID:SGTC_168|Compound:3970-0862|FD-Score:4.25|P-value:1.14E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:6.69|P-value:6.03E-14 ID:SGTC_214|Compound:4373-3496|FD-Score:5.00|P-value:1.43E-8 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.43|P-value:8.16E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.07|P-value:3.71E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.25|P-value:1.51E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.45|P-value:4.00E-13 ID:SGTC_291|Compound:4130-1278|FD-Score:-2.90|P-value:7.40E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.61|P-value:1.54E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:3.91|P-value:7.02E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:6.84|P-value:1.57E-14 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.78|P-value:7.24E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:4.57|P-value:1.96E-7 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.52|P-value:2.50E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:6.02|P-value:1.23E-11 ID:SGTC_650|Compound:1328-0195|FD-Score:3.43|P-value:6.72E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.95|P-value:5.60E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.03|P-value:3.64E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:7.73|P-value:4.97E-18 ID:SGTC_743|Compound:1275-0778|FD-Score:3.93|P-value:6.08E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:3.74|P-value:1.59E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:2.91|P-value:5.85E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.11|P-value:3.15E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.91|P-value:5.84E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.60|P-value:2.63E-10 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.78|P-value:9.86E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.82|P-value:1.36E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.83|P-value:8.09E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-2.90|P-value:7.35E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-6.56|P-value:2.40E-13 ID:SGTC_1168|Compound:k815-0004|FD-Score:2.82|P-value:8.49E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-2.89|P-value:7.54E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.98|P-value:4.56E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:2.81|P-value:8.85E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.13|P-value:2.42E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.53|P-value:4.23E-10 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.62|P-value:2.82E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:3.51E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.38|P-value:8.46E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.26|P-value:1.43E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.39|P-value:7.99E-5 ID:SGTC_1620|Compound:st003704|FD-Score:-2.97|P-value:5.54E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-2.83|P-value:9.53E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.79|P-value:9.24E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.25|P-value:1.51E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.34|P-value:1.00E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.34|P-value:1.20E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.05|P-value:3.46E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.81|P-value:5.93E-8 ID:SGTC_1979|Compound:st071809|FD-Score:-5.40|P-value:1.31E-9 ID:SGTC_1984|Compound:st072354|FD-Score:-2.82|P-value:9.68E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.79|P-value:9.25E-4 ID:SGTC_1990|Compound:st072050|FD-Score:2.85|P-value:7.60E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.75|P-value:1.54E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.25|P-value:1.52E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.04|P-value:3.57E-6 ID:SGTC_2116|Compound:5511452|FD-Score:2.90|P-value:6.12E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.62|P-value:2.15E-10 ID:SGTC_2139|Compound:5578692|FD-Score:2.87|P-value:6.96E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-2.82|P-value:9.94E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.17|P-value:2.51E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.30|P-value:1.47E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.39|P-value:8.24E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-4.04|P-value:4.42E-6 ID:SGTC_2446|Compound:5162541|FD-Score:2.96|P-value:4.84E-4 ID:SGTC_2483|Compound:5729050|FD-Score:6.26|P-value:1.94E-12 ID:SGTC_2487|Compound:5918373|FD-Score:5.90|P-value:2.91E-11 ID:SGTC_2488|Compound:5268135|FD-Score:-2.88|P-value:7.95E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.04|P-value:3.57E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.14|P-value:2.06E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.80|P-value:1.46E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.07|P-value:3.19E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.82|P-value:8.55E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:24.20|P-value:6.73E-158 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.18|P-value:2.04E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:4.44E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.38|P-value:8.54E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.67|P-value:2.19E-5 ID:SGTC_2894|Compound:9048625|FD-Score:2.95|P-value:5.08E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.53|P-value:4.38E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-2.84|P-value:8.99E-4 ID:SGTC_2933|Compound:9026794|FD-Score:2.78|P-value:9.89E-4 ID:SGTC_2936|Compound:9038235|FD-Score:7.00|P-value:4.23E-15 ID:SGTC_2955|Compound:9076254|FD-Score:3.96|P-value:5.46E-6 ID:SGTC_2959|Compound:9079155|FD-Score:2.80|P-value:8.95E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-3.05|P-value:4.10E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.70|P-value:1.13E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-4.28|P-value:1.21E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.88|P-value:8.00E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.92|P-value:5.81E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-2.90|P-value:7.16E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-2.99|P-value:5.22E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.24|P-value:1.56E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.02|P-value:3.88E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.46|P-value:5.80E-5

Top fitness defect scores for YJL019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2651 1327-0036 24.20 5.0 µM 6.73E-158 2 2.56E-129 1.62
2 SGTC_163 1327-0036 13.10 7.5 µM 3.05E-48 6 1.06E-39 0.75
3 SGTC_690 glyoxal 7.73 20.3 µM 4.97E-18 8 5.25E-15 1.66
4 SGTC_2936 9038235 7.00 15.6 µM 4.23E-15 1 1.31E-12 1.57
5 SGTC_309 k408-0051 6.84 1.5 µM 1.57E-14 6 3.84E-12 0.51
6 SGTC_184 1494-0393 6.69 24.7 µM 6.03E-14 7 1.15E-11 0.19
7 SGTC_266 formosanin C 6.45 406.0 nM 4.00E-13 sphingolipid biosynthesis & PDR1 6 5.42E-11 0.57
8 SGTC_2483 5729050 6.26 27.2 µM 1.94E-12 1 1.97E-10 1.33
9 SGTC_514 4466-0038 6.02 2.6 nM 1.23E-11 cell wall 17 8.93E-10 0.25
10 SGTC_2487 5918373 5.90 44.0 µM 2.91E-11 1 1.81E-9 0.76
11 SGTC_2125 5246583 5.62 200.0 µM 2.15E-10 tubulin folding & SWR complex 2 9.30E-9 0.84
12 SGTC_994 3910-0338 5.60 138.0 µM 2.63E-10 calcium & mitochondrial duress 4 1.10E-8 0.50
13 SGTC_1453 4237-0541 5.53 195.0 µM 4.23E-10 heme biosynthesis & mitochondrial translocase 11 1.62E-8 0.42
14 SGTC_81 0411-0046 5.19 10.0 µM 4.08E-9 25 1.04E-7 0.04
15 SGTC_214 4373-3496 5.00 70.0 µM 1.43E-8 7 2.90E-7 0.01
16 SGTC_299 1273-0059 4.61 1.4 µM 1.54E-7 6 2.04E-6 0.12
17 SGTC_371 0195-0006 4.57 7.4 µM 1.96E-7 8 2.48E-6 0.63
18 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 4.52 8.0 µM 2.50E-7 10 3.02E-6 0.49
19 SGTC_2688 kanamycin b 4.42 96.7 µM 4.44E-7 calcium & mitochondrial duress 15 4.85E-6 0.09
20 SGTC_168 3970-0862 4.25 530.5 µM 1.14E-6 40 1.05E-5 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.484 9.86E-197 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.476 1.74E-189 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.475 1.23E-188 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.457 3.50E-173 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.421 1.27E-144 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.401 1.36E-129 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.381 2.02E-116 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.361 5.79E-104 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.325 2.49E-83 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.313 4.69E-77 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.304 7.15E-73 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.286 3.71E-64 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.286 4.03E-64 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.279 5.64E-61 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.273 2.64E-58 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member