YJL020C / BBC1

Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL020C / BBC1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.93|P-value:4.05E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:3.00|P-value:5.85E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.88|P-value:8.98E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.26|P-value:2.57E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.63|P-value:4.26E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.74|P-value:2.65E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.79|P-value:2.10E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:2.89|P-value:8.52E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.26|P-value:2.04E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.14|P-value:3.39E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.66|P-value:3.71E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.14|P-value:3.39E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.12|P-value:4.22E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.63|P-value:4.28E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.50|P-value:7.55E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.34|P-value:1.50E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.26|P-value:2.57E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.29|P-value:1.86E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.09|P-value:4.97E-6 ID:SGTC_2090|Compound:5301565|FD-Score:-2.94|P-value:8.75E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.46|P-value:9.09E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.32|P-value:2.05E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.88|P-value:1.35E-5 ID:SGTC_2294|Compound:7971431|FD-Score:2.99|P-value:5.89E-4 ID:SGTC_2303|Compound:7774051|FD-Score:5.00|P-value:3.30E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.66|P-value:3.67E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.19|P-value:2.90E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.02|P-value:5.39E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.81|P-value:1.84E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.09|P-value:4.98E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.99|P-value:3.63E-8 ID:SGTC_2785|Compound:7756463|FD-Score:-3.00|P-value:7.16E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.34|P-value:1.50E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.32|P-value:2.02E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-3.28|P-value:2.43E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.23|P-value:2.96E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.29|P-value:2.29E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.93|P-value:4.05E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:3.00|P-value:5.85E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:2.88|P-value:8.98E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.26|P-value:2.57E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.63|P-value:4.26E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.74|P-value:2.65E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.79|P-value:2.10E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:2.89|P-value:8.52E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.26|P-value:2.04E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.14|P-value:3.39E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.66|P-value:3.71E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.14|P-value:3.39E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.12|P-value:4.22E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.63|P-value:4.28E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.50|P-value:7.55E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.34|P-value:1.50E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.26|P-value:2.57E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.29|P-value:1.86E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.09|P-value:4.97E-6 ID:SGTC_2090|Compound:5301565|FD-Score:-2.94|P-value:8.75E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.46|P-value:9.09E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.32|P-value:2.05E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.88|P-value:1.35E-5 ID:SGTC_2294|Compound:7971431|FD-Score:2.99|P-value:5.89E-4 ID:SGTC_2303|Compound:7774051|FD-Score:5.00|P-value:3.30E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.66|P-value:3.67E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.19|P-value:2.90E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.02|P-value:5.39E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.81|P-value:1.84E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.09|P-value:4.98E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.99|P-value:3.63E-8 ID:SGTC_2785|Compound:7756463|FD-Score:-3.00|P-value:7.16E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.34|P-value:1.50E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.32|P-value:2.02E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-3.28|P-value:2.43E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.23|P-value:2.96E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.29|P-value:2.29E-6

Top fitness defect scores for YJL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 6.93 9.0 µM 4.05E-14 cell wall 166 2.16E-12
2 SGTC_2303 7774051 5.00 200.0 µM 3.30E-8 10 2.84E-7
3 SGTC_2584 androsterone 4.99 48.7 µM 3.63E-8 cell wall 82 3.08E-7
4 SGTC_2563 tomatine 4.19 8.5 µM 2.90E-6 36 1.37E-5
5 SGTC_1251 0490-5699 4.12 265.0 µM 4.22E-6 29 1.90E-5
6 SGTC_2055 5235184 4.09 200.0 µM 4.97E-6 ERG2 25 2.19E-5
7 SGTC_2292 7671323 3.88 168.1 µM 1.35E-5 RNA processing & uracil transport 34 5.22E-5
8 SGTC_2572 astragaloside iv 3.81 100.0 µM 1.84E-5 30 6.83E-5
9 SGTC_539 4859-0462 3.79 2.5 µM 2.10E-5 RNA pol III & RNase P/MRP 31 7.64E-5
10 SGTC_454 lyso-paf C-16 3.74 6.7 µM 2.65E-5 22 9.36E-5
11 SGTC_2357 9067248 3.66 200.0 µM 3.67E-5 29 1.24E-4
12 SGTC_1204 4049-0315 3.66 18.3 µM 3.71E-5 42 1.25E-4
13 SGTC_246 cycloheximide 3.63 667.0 µM 4.26E-5 20 1.41E-4
14 SGTC_1322 1348-1070 3.63 12.0 µM 4.28E-5 11 1.42E-4
15 SGTC_1630 st005209 3.50 31.3 µM 7.55E-5 39 2.32E-4
16 SGTC_2182 6325192 3.46 200.0 µM 9.09E-5 Golgi 24 2.72E-4
17 SGTC_1701 st028638 3.34 40.4 µM 1.50E-4 30 4.21E-4
18 SGTC_2978 9011784 3.34 43.0 µM 1.50E-4 58 4.22E-4
19 SGTC_1787 fluconazole 3.29 80.0 µM 1.86E-4 iron homeostasis 69 5.08E-4
20 SGTC_1112 tnp00069 3.26 1.2 µM 2.04E-4 54 5.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.221 2.35E-38 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.219 1.07E-37 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.214 5.55E-36 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.206 1.43E-33 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.202 5.14E-32 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.189 3.47E-28 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.186 1.34E-27 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.183 9.96E-27 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.182 2.05E-26 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.182 2.85E-26 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.179 1.17E-25 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.174 3.91E-24 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.172 8.46E-24 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.170 5.00E-23 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.167 1.68E-22 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication