YJL025W / RRN7

Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL025W / RRN7

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.75|P-value:6.72E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:3.67|P-value:9.51E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:4.33|P-value:5.42E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.55|P-value:2.77E-6 ID:SGTC_85|Compound:0868-0259|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.40|P-value:2.72E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.33|P-value:3.52E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.36|P-value:4.73E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:4.62|P-value:1.34E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.45|P-value:2.26E-4 ID:SGTC_264|Compound:promethazine|FD-Score:10.00|P-value:2.45E-24 ID:SGTC_343|Compound:4130-2827|FD-Score:4.26|P-value:7.56E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.29|P-value:6.68E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:3.58|P-value:1.38E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.47|P-value:2.07E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.91|P-value:3.48E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.45|P-value:2.21E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.09|P-value:8.11E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.12|P-value:9.60E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:5.56|P-value:8.57E-9 ID:SGTC_872|Compound:0588-0139|FD-Score:3.35|P-value:3.30E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.18|P-value:5.94E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.12|P-value:9.41E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.32|P-value:3.61E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.45|P-value:2.25E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.17|P-value:7.99E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-4.66|P-value:1.64E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.73|P-value:7.32E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.70|P-value:3.86E-9 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.57|P-value:2.51E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.14|P-value:1.28E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:5.81|P-value:1.94E-9 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.58|P-value:1.68E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:6.11|P-value:2.95E-10 ID:SGTC_1519|Compound:esterone|FD-Score:5.27|P-value:4.48E-8 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.53|P-value:2.17E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.43|P-value:3.16E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.04|P-value:9.86E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.31|P-value:4.91E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.07|P-value:1.33E-7 ID:SGTC_1930|Compound:st074634|FD-Score:8.36|P-value:1.39E-17 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.74|P-value:7.20E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-3.21|P-value:6.90E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.35|P-value:3.23E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.53|P-value:1.63E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.19|P-value:7.57E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.49|P-value:3.67E-6 ID:SGTC_2989|Compound:9073649|FD-Score:-3.52|P-value:2.26E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.04|P-value:9.60E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.87|P-value:1.32E-9 ID:SGTC_3072|Compound:9116419|FD-Score:-4.88|P-value:5.26E-7 ID:SGTC_3103|Compound:9120822|FD-Score:-3.21|P-value:7.11E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.32|P-value:3.61E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.87|P-value:4.20E-5 ID:SGTC_3283|Compound:9109332|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:3.75|P-value:6.72E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:3.67|P-value:9.51E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:4.33|P-value:5.42E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.55|P-value:2.77E-6 ID:SGTC_85|Compound:0868-0259|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.40|P-value:2.72E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.33|P-value:3.52E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.36|P-value:4.73E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:4.62|P-value:1.34E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.45|P-value:2.26E-4 ID:SGTC_264|Compound:promethazine|FD-Score:10.00|P-value:2.45E-24 ID:SGTC_343|Compound:4130-2827|FD-Score:4.26|P-value:7.56E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.29|P-value:6.68E-6 ID:SGTC_380|Compound:3970-0968|FD-Score:3.58|P-value:1.38E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.47|P-value:2.07E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.91|P-value:3.48E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.45|P-value:2.21E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.09|P-value:8.11E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.12|P-value:9.60E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:5.56|P-value:8.57E-9 ID:SGTC_872|Compound:0588-0139|FD-Score:3.35|P-value:3.30E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.18|P-value:5.94E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.12|P-value:9.41E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.32|P-value:3.61E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.45|P-value:2.25E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.17|P-value:7.99E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-4.66|P-value:1.64E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.73|P-value:7.32E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.70|P-value:3.86E-9 ID:SGTC_1469|Compound:k284-2957|FD-Score:-4.57|P-value:2.51E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.14|P-value:1.28E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:5.81|P-value:1.94E-9 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.58|P-value:1.68E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:6.11|P-value:2.95E-10 ID:SGTC_1519|Compound:esterone|FD-Score:5.27|P-value:4.48E-8 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.53|P-value:2.17E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.43|P-value:3.16E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.04|P-value:9.86E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.31|P-value:4.91E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.07|P-value:1.33E-7 ID:SGTC_1930|Compound:st074634|FD-Score:8.36|P-value:1.39E-17 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.74|P-value:7.20E-5 ID:SGTC_2155|Compound:5570423|FD-Score:-3.21|P-value:6.90E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.35|P-value:3.23E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.53|P-value:1.63E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.19|P-value:7.57E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.49|P-value:3.67E-6 ID:SGTC_2989|Compound:9073649|FD-Score:-3.52|P-value:2.26E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.04|P-value:9.60E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.87|P-value:1.32E-9 ID:SGTC_3072|Compound:9116419|FD-Score:-4.88|P-value:5.26E-7 ID:SGTC_3103|Compound:9120822|FD-Score:-3.21|P-value:7.11E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.32|P-value:3.61E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.87|P-value:4.20E-5 ID:SGTC_3283|Compound:9109332|FD-Score:3.55|P-value:1.53E-4

Top fitness defect scores for YJL025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_264 promethazine 10.00 12.5 mM 2.45E-24 DNA intercalators 4 7.25E-24 0.23
2 SGTC_1930 st074634 8.36 34.3 µM 1.39E-17 RNA pol III & RNase P/MRP 4 3.13E-17 0.45
3 SGTC_1515 3460-0031 6.11 42.1 µM 2.95E-10 DNA intercalators 2 4.88E-10 1.57
4 SGTC_3040 9091894 5.87 49.5 µM 1.32E-9 DNA intercalators 2 2.12E-9 0.21
5 SGTC_1487 3970-0795 5.81 2.8 µM 1.94E-9 DNA intercalators 2 3.09E-9 0.99
6 SGTC_1468 k284-1086 5.70 134.0 µM 3.86E-9 DNA intercalators 5 6.08E-9 0.25
7 SGTC_867 0518-0118 5.56 155.0 µM 8.57E-9 DNA intercalators 7 1.33E-8 0.02
8 SGTC_1519 esterone 5.27 74.0 µM 4.48E-8 DNA intercalators 2 6.71E-8 0.72
9 SGTC_1926 methyl fluorone black 5.07 53.6 µM 1.33E-7 DNA intercalators 15 1.95E-7 0.06
10 SGTC_145 3737-0113 4.62 38.4 µM 1.34E-6 DNA intercalators 36 1.88E-6 0.04
11 SGTC_1494 4358-1428 4.58 177.0 µM 1.68E-6 5 2.35E-6 0.04
12 SGTC_144 4161-2749 4.36 112.4 µM 4.73E-6 DNA intercalators 10 6.45E-6 0.04
13 SGTC_9 0092-0002 4.33 10.4 µM 5.42E-6 11 7.37E-6 0.10
14 SGTC_370 0180-0345 4.29 38.7 µM 6.68E-6 DNA intercalators 5 9.05E-6 0.03
15 SGTC_343 4130-2827 4.26 29.8 µM 7.56E-6 5 1.02E-5 0.92
16 SGTC_1475 4092-1048 4.14 11.7 µM 1.28E-5 plasma membrane duress 4 1.71E-5 0.29
17 SGTC_471 1-acyl-paf 3.91 4.0 µM 3.48E-5 DNA intercalators 18 4.56E-5 0.04
18 SGTC_3244 9134489 3.87 49.5 µM 4.20E-5 2 5.47E-5 0.15
19 SGTC_2 0422-0095 3.75 29.0 µM 6.72E-5 redox potentiating 4 8.67E-5 0.12
20 SGTC_2131 toluylene red 3.74 5.3 µM 7.20E-5 60S ribosome export 16 9.28E-5 0.26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.440 5.08E-159 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.440 2.43E-158 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.430 1.18E-150 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.419 1.13E-142 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.393 1.09E-123 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.387 2.58E-120 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.385 1.37E-118 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.345 1.52E-94 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.336 7.21E-89 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.329 2.33E-85 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.285 1.87E-63 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.273 1.53E-58 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.261 4.05E-53 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.250 8.42E-49 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.248 2.96E-48 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication