YJL027C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL027C / YJL027C

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:6.29|P-value:3.61E-11 ID:SGTC_273|Compound:hydroxyurea|FD-Score:32.70|P-value:4.34E-249 ID:SGTC_372|Compound:0155-0182|FD-Score:3.79|P-value:4.10E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.51|P-value:1.33E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.83|P-value:3.51E-5 ID:SGTC_462|Compound:ag-879|FD-Score:4.06|P-value:1.26E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:5.54|P-value:4.86E-9 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.93|P-value:2.31E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.89|P-value:3.32E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.99|P-value:9.27E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:5.74|P-value:1.35E-9 ID:SGTC_624|Compound:k048-0052|FD-Score:4.68|P-value:6.07E-7 ID:SGTC_725|Compound:1497-0963|FD-Score:3.09|P-value:6.48E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.17|P-value:4.89E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.35|P-value:3.17E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.08|P-value:8.20E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.84|P-value:3.41E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.61|P-value:1.08E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.07|P-value:7.40E-8 ID:SGTC_1227|Compound:3909-8010|FD-Score:6.23|P-value:5.45E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.29|P-value:3.80E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.28|P-value:3.27E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.10|P-value:6.36E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-5.94|P-value:5.56E-10 ID:SGTC_1675|Compound:st018485|FD-Score:-5.25|P-value:3.51E-8 ID:SGTC_1678|Compound:st019265|FD-Score:4.10|P-value:1.07E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.19|P-value:5.49E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.72|P-value:7.11E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.25|P-value:4.46E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.91|P-value:2.37E-7 ID:SGTC_2273|Compound:7815444|FD-Score:3.43|P-value:1.85E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.23|P-value:5.81E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-3.27|P-value:4.20E-4 ID:SGTC_2295|Compound:7971645|FD-Score:5.32|P-value:1.83E-8 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.25|P-value:4.51E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:7.36|P-value:1.36E-14 ID:SGTC_3081|Compound:9117243|FD-Score:3.00|P-value:9.14E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.04|P-value:9.37E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.35|P-value:2.53E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.84|P-value:4.26E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:6.29|P-value:3.61E-11 ID:SGTC_273|Compound:hydroxyurea|FD-Score:32.70|P-value:4.34E-249 ID:SGTC_372|Compound:0155-0182|FD-Score:3.79|P-value:4.10E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.51|P-value:1.33E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.83|P-value:3.51E-5 ID:SGTC_462|Compound:ag-879|FD-Score:4.06|P-value:1.26E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:5.54|P-value:4.86E-9 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.93|P-value:2.31E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.89|P-value:3.32E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:2.99|P-value:9.27E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:5.74|P-value:1.35E-9 ID:SGTC_624|Compound:k048-0052|FD-Score:4.68|P-value:6.07E-7 ID:SGTC_725|Compound:1497-0963|FD-Score:3.09|P-value:6.48E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.17|P-value:4.89E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.35|P-value:3.17E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.08|P-value:8.20E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.84|P-value:3.41E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.61|P-value:1.08E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:5.07|P-value:7.40E-8 ID:SGTC_1227|Compound:3909-8010|FD-Score:6.23|P-value:5.45E-11 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.29|P-value:3.80E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.28|P-value:3.27E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.10|P-value:6.36E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-5.94|P-value:5.56E-10 ID:SGTC_1675|Compound:st018485|FD-Score:-5.25|P-value:3.51E-8 ID:SGTC_1678|Compound:st019265|FD-Score:4.10|P-value:1.07E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.19|P-value:5.49E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.72|P-value:7.11E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.25|P-value:4.46E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.91|P-value:2.37E-7 ID:SGTC_2273|Compound:7815444|FD-Score:3.43|P-value:1.85E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.23|P-value:5.81E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-3.27|P-value:4.20E-4 ID:SGTC_2295|Compound:7971645|FD-Score:5.32|P-value:1.83E-8 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.25|P-value:4.51E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:7.36|P-value:1.36E-14 ID:SGTC_3081|Compound:9117243|FD-Score:3.00|P-value:9.14E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.04|P-value:9.37E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.35|P-value:2.53E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.84|P-value:4.26E-5

Top fitness defect scores for YJL027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_273 hydroxyurea 32.70 18.1 mM 4.34E-249 heme biosynthesis & mitochondrial translocase 1 3.91E-234
2 SGTC_2770 toltrazuril 7.36 17.5 µM 1.36E-14 3 9.42E-14
3 SGTC_157 1348-1695 6.29 65.8 µM 3.61E-11 iron homeostasis 20 1.54E-10
4 SGTC_1227 3909-8010 6.23 46.6 µM 5.45E-11 2 2.27E-10
5 SGTC_604 1000-0114 5.74 314.0 µM 1.35E-9 2 4.61E-9
6 SGTC_472 calcifediol 5.54 10.0 µM 4.86E-9 1 1.53E-8
7 SGTC_2295 7971645 5.32 200.0 µM 1.83E-8 9 5.32E-8
8 SGTC_1221 2958-7315 5.07 257.0 µM 7.40E-8 6 1.97E-7
9 SGTC_624 k048-0052 4.68 28.0 µM 6.07E-7 Golgi 8 1.42E-6
10 SGTC_1186 1319-0216 4.35 26.0 µM 3.17E-6 12 6.70E-6
11 SGTC_2283 7944793 4.23 200.0 µM 5.81E-6 32 1.18E-5
12 SGTC_1678 st019265 4.10 80.2 µM 1.07E-5 60S ribosome export 16 2.10E-5
13 SGTC_462 ag-879 4.06 158.0 µM 1.26E-5 27 2.45E-5
14 SGTC_491 tetrandrine 3.93 80.3 µM 2.31E-5 12 4.32E-5
15 SGTC_1212 0520-0165 3.84 585.0 µM 3.41E-5 36 6.22E-5
16 SGTC_387 norethindrone acetate 3.83 66.7 µM 3.51E-5 18 6.40E-5
17 SGTC_372 0155-0182 3.79 15.9 µM 4.10E-5 mitochondrial response to ROS 32 7.41E-5
18 SGTC_381 3461-2219 3.57 42.7 µM 1.04E-4 copper-dependent oxidative stress 28 1.77E-4
19 SGTC_379 3970-0972 3.51 5.9 µM 1.33E-4 tubulin folding & SWR complex 51 2.23E-4
20 SGTC_1682 st012968 3.43 530.0 nM 1.82E-4 35 2.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.386 6.48E-120 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.181 4.12E-26 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.180 7.88E-26 YBR237W PRP5 het RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
0.172 8.23E-24 YCR086W CSM1 hom Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.171 2.37E-23 YHL013C OTU2 hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
0.164 1.50E-21 YDR423C CAD1 hom AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
0.163 1.80E-21 YPL207W TYW1 hom Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron
0.147 9.99E-18 YGR180C RNR4 hom Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.142 1.49E-16 YNL114C_d YNL114C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
0.137 2.01E-15 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.136 2.76E-15 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.136 3.17E-15 YKR076W ECM4 hom Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.133 9.13E-15 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.129 5.61E-14 YDL163W_d YDL163W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
0.128 1.07E-13 YBR133C HSL7 hom Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress