YJL038C / LOH1

Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL038C / LOH1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.39|P-value:3.21E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.47|P-value:2.33E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.41|P-value:2.96E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.16|P-value:8.09E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.93|P-value:4.34E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.34|P-value:4.28E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.41|P-value:3.34E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.82|P-value:6.84E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.45|P-value:2.88E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.93|P-value:4.39E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.13|P-value:8.95E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-4.67|P-value:1.27E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:3.88|P-value:5.38E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.08|P-value:1.95E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.43|P-value:3.06E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:5.39|P-value:3.53E-8 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.25|P-value:5.92E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.29|P-value:5.22E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.94|P-value:3.90E-7 ID:SGTC_1649|Compound:st011737|FD-Score:3.80|P-value:7.45E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.29|P-value:5.08E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.22|P-value:5.91E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.36|P-value:4.03E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.16|P-value:7.98E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.71|P-value:9.14E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.89|P-value:5.07E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.12|P-value:8.29E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.30|P-value:5.04E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.17|P-value:6.89E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.08|P-value:2.30E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.10|P-value:2.13E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.80|P-value:6.47E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.60|P-value:1.07E-8 ID:SGTC_2601|Compound:securinine|FD-Score:3.42|P-value:3.18E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.98|P-value:3.59E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.83|P-value:6.45E-5 ID:SGTC_2652|Compound:actinonin|FD-Score:3.30|P-value:4.99E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.74|P-value:9.29E-5 ID:SGTC_3162|Compound:9099653|FD-Score:-3.69|P-value:9.87E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.45|P-value:2.87E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.39|P-value:3.21E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.47|P-value:2.33E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.41|P-value:2.96E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.16|P-value:8.09E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.93|P-value:4.34E-5 ID:SGTC_271|Compound:rotenone|FD-Score:3.34|P-value:4.28E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.41|P-value:3.34E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.82|P-value:6.84E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.45|P-value:2.88E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.93|P-value:4.39E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.13|P-value:8.95E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-4.67|P-value:1.27E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:3.88|P-value:5.38E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.08|P-value:1.95E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.43|P-value:3.06E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:5.39|P-value:3.53E-8 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.25|P-value:5.92E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.29|P-value:5.22E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.94|P-value:3.90E-7 ID:SGTC_1649|Compound:st011737|FD-Score:3.80|P-value:7.45E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.29|P-value:5.08E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.22|P-value:5.91E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.36|P-value:4.03E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.16|P-value:7.98E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.71|P-value:9.14E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.89|P-value:5.07E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.12|P-value:8.29E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.30|P-value:5.04E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.17|P-value:6.89E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.08|P-value:2.30E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.10|P-value:2.13E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.80|P-value:6.47E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.60|P-value:1.07E-8 ID:SGTC_2601|Compound:securinine|FD-Score:3.42|P-value:3.18E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.98|P-value:3.59E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.83|P-value:6.45E-5 ID:SGTC_2652|Compound:actinonin|FD-Score:3.30|P-value:4.99E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.74|P-value:9.29E-5 ID:SGTC_3162|Compound:9099653|FD-Score:-3.69|P-value:9.87E-5 ID:SGTC_3352|Compound:9151559|FD-Score:3.45|P-value:2.87E-4

Top fitness defect scores for YJL038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2596 sinensetin 5.60 100.0 µM 1.07E-8 7 1.07E-8
2 SGTC_1443 4112-3303 5.39 14.0 µM 3.53E-8 1 3.51E-8
3 SGTC_1638 st008370 4.94 60.6 µM 3.90E-7 ergosterol biosynthesis 16 3.86E-7
4 SGTC_2589 lobaric acid 4.10 100.0 µM 2.13E-5 23 2.08E-5
5 SGTC_2498 4'-Methoxychalcone 4.08 54.6 µM 2.30E-5 RPP1 & pyrimidine depletion 33 2.25E-5
6 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 3.98 100.0 µM 3.59E-5 22 3.52E-5
7 SGTC_141 0443-0274 3.93 32.3 µM 4.34E-5 mitochondrial response to ROS 41 4.24E-5
8 SGTC_747 3448-8087 3.93 38.7 µM 4.39E-5 26 4.29E-5
9 SGTC_2269 7935389 3.89 174.4 µM 5.07E-5 tubulin folding & SWR complex 26 4.96E-5
10 SGTC_996 3970-0799 3.88 1.8 µM 5.38E-5 84 5.26E-5
11 SGTC_2636 apigenin dimethyl ether 3.83 100.0 µM 6.45E-5 52 6.30E-5
12 SGTC_391 gliotoxin 3.82 8.3 µM 6.84E-5 69 6.69E-5
13 SGTC_1649 st011737 3.80 51.3 µM 7.45E-5 30 7.28E-5
14 SGTC_3159 9100096 3.74 49.5 µM 9.29E-5 25 9.07E-5
15 SGTC_2320 7373003 3.67 200.0 µM 1.25E-4 34 1.22E-4
16 SGTC_1391 3442-0225 3.63 151.0 µM 1.45E-4 23 1.42E-4
17 SGTC_3352 9151559 3.45 45.6 µM 2.87E-4 23 2.80E-4
18 SGTC_665 3914-0008 3.45 307.0 µM 2.88E-4 32 2.81E-4
19 SGTC_1429 4049-0205 3.43 9.5 µM 3.06E-4 22 2.98E-4
20 SGTC_2601 securinine 3.42 100.0 µM 3.18E-4 44 3.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.57E-16 YGR235C MOS2 hom Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.138 8.35E-16 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.128 1.04E-13 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.120 3.12E-12 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.110 1.69E-10 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.099 1.10E-8 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.095 3.65E-8 YGL059W PKP2 hom Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.090 1.57E-7 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.088 3.83E-7 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.086 5.30E-7 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
0.086 6.11E-7 YIR030C DCG1 hom Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
0.084 1.00E-6 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.083 1.61E-6 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.081 2.59E-6 YGL258W VEL1 hom Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C
0.080 3.73E-6 YLR248W RCK2 hom Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication