YJL041W / NSP1

FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL041W / NSP1

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:3.72|P-value:8.95E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.40|P-value:3.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.28|P-value:4.84E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.33|P-value:4.05E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.96|P-value:2.98E-7 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.09|P-value:9.35E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.22|P-value:5.90E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.12|P-value:8.38E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.15|P-value:7.63E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.41|P-value:2.97E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.49|P-value:2.18E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.28|P-value:4.71E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.13|P-value:8.06E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.75|P-value:7.80E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.78|P-value:6.89E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.07|P-value:9.92E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.69|P-value:9.94E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.84|P-value:5.51E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.17|P-value:7.07E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.74|P-value:8.19E-5 ID:SGTC_2138|Compound:5575593|FD-Score:-3.25|P-value:5.27E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.07|P-value:9.86E-4 ID:SGTC_2160|Compound:5660466|FD-Score:8.24|P-value:5.41E-17 ID:SGTC_2313|Compound:7726885|FD-Score:-3.96|P-value:3.25E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.35|P-value:3.65E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.97|P-value:2.82E-7 ID:SGTC_2338|Compound:7999974|FD-Score:5.62|P-value:7.47E-9 ID:SGTC_2350|Compound:9023895|FD-Score:3.63|P-value:1.28E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.41|P-value:2.98E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.11|P-value:8.53E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.34|P-value:3.85E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.72|P-value:9.02E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.68|P-value:1.24E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:-3.11|P-value:8.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.52|P-value:1.98E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.17|P-value:7.10E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-5.29|P-value:4.98E-8 ID:SGTC_2981|Compound:9013952|FD-Score:4.81|P-value:6.33E-7 ID:SGTC_3030|Compound:9087619|FD-Score:-3.24|P-value:5.49E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-4.16|P-value:1.40E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-4.81|P-value:6.25E-7 ID:SGTC_3112|Compound:9123419|FD-Score:-3.41|P-value:2.97E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-5.21|P-value:7.50E-8 ID:SGTC_3121|Compound:9125696|FD-Score:4.10|P-value:1.80E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.18|P-value:6.80E-4 ID:SGTC_3251|Compound:9135047|FD-Score:4.30|P-value:7.58E-6 ID:SGTC_3275|Compound:9138069|FD-Score:4.68|P-value:1.21E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.72|P-value:8.95E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.40|P-value:3.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.28|P-value:4.84E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.33|P-value:4.05E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.96|P-value:2.98E-7 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.09|P-value:9.35E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.22|P-value:5.90E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.12|P-value:8.38E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.15|P-value:7.63E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.41|P-value:2.97E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.49|P-value:2.18E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.28|P-value:4.71E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.13|P-value:8.06E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.75|P-value:7.80E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.78|P-value:6.89E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.07|P-value:9.92E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.69|P-value:9.94E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.84|P-value:5.51E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-3.17|P-value:7.07E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.74|P-value:8.19E-5 ID:SGTC_2138|Compound:5575593|FD-Score:-3.25|P-value:5.27E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.07|P-value:9.86E-4 ID:SGTC_2160|Compound:5660466|FD-Score:8.24|P-value:5.41E-17 ID:SGTC_2313|Compound:7726885|FD-Score:-3.96|P-value:3.25E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.35|P-value:3.65E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_2333|Compound:9017922|FD-Score:4.97|P-value:2.82E-7 ID:SGTC_2338|Compound:7999974|FD-Score:5.62|P-value:7.47E-9 ID:SGTC_2350|Compound:9023895|FD-Score:3.63|P-value:1.28E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.41|P-value:2.98E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.11|P-value:8.53E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.34|P-value:3.85E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.72|P-value:9.02E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.68|P-value:1.24E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:-3.11|P-value:8.51E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.52|P-value:1.98E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.17|P-value:7.10E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-5.29|P-value:4.98E-8 ID:SGTC_2981|Compound:9013952|FD-Score:4.81|P-value:6.33E-7 ID:SGTC_3030|Compound:9087619|FD-Score:-3.24|P-value:5.49E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-4.16|P-value:1.40E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-4.81|P-value:6.25E-7 ID:SGTC_3112|Compound:9123419|FD-Score:-3.41|P-value:2.97E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-5.21|P-value:7.50E-8 ID:SGTC_3121|Compound:9125696|FD-Score:4.10|P-value:1.80E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.18|P-value:6.80E-4 ID:SGTC_3251|Compound:9135047|FD-Score:4.30|P-value:7.58E-6 ID:SGTC_3275|Compound:9138069|FD-Score:4.68|P-value:1.21E-6

Top fitness defect scores for YJL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2160 5660466 8.24 132.9 µM 5.41E-17 60S ribosome export 1 8.92E-17 1.15
2 SGTC_2338 7999974 5.62 200.0 µM 7.47E-9 3 9.45E-9 1.22
3 SGTC_2333 9017922 4.97 200.0 µM 2.82E-7 2 3.40E-7 0.35
4 SGTC_2981 9013952 4.81 39.0 µM 6.33E-7 3 7.54E-7 0.12
5 SGTC_3275 9138069 4.68 49.5 µM 1.21E-6 1 1.42E-6 0.93
6 SGTC_2729 fluphenazine 4.68 10.7 µM 1.24E-6 4 1.46E-6 0.36
7 SGTC_3251 9135047 4.30 49.5 µM 7.58E-6 60S ribosome export 3 8.72E-6 0.06
8 SGTC_3121 9125696 4.10 49.5 µM 1.80E-5 1 2.04E-5 0.56
9 SGTC_1846 st056244 3.84 14.8 µM 5.51E-5 5 6.17E-5 0.19
10 SGTC_1860 st056228 3.74 74.6 µM 8.19E-5 7 9.12E-5 0.14
11 SGTC_103 0844-0104 3.72 51.8 µM 8.95E-5 ERAD & cell cycle 53 9.95E-5 0.03
12 SGTC_2581 avocatin a 3.72 64.0 µM 9.02E-5 sphingolipid biosynthesis & PDR1 9 1.00E-4 0.03
13 SGTC_2350 9023895 3.63 38.9 µM 1.28E-4 ergosterol biosynthesis 12 1.42E-4 0.52
14 SGTC_2332 7982454 3.55 138.9 µM 1.74E-4 13 1.92E-4 0.02
15 SGTC_1313 1220-0047 3.49 237.0 µM 2.18E-4 10 2.39E-4 0.28
16 SGTC_248 streptozotocin 3.40 5.2 mM 3.13E-4 DNA damage response 20 3.43E-4 0.07
17 SGTC_2317 5986382 3.35 200.0 µM 3.65E-4 10 3.98E-4 0.20
18 SGTC_2480 5767542 3.34 37.2 µM 3.85E-4 7 4.20E-4 0.22
19 SGTC_568 1193-0097 3.33 7.5 µM 4.05E-4 ERAD & cell cycle 35 4.41E-4 0.03
20 SGTC_2883 9059145 3.31 45.5 µM 4.35E-4 12 4.73E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.10E-14 YOR058C ASE1 hom Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
0.116 1.82E-11 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.108 3.08E-10 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.106 6.39E-10 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.105 1.23E-9 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.102 3.63E-9 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 2.01E-8 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.093 6.02E-8 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.092 1.04E-7 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.091 1.24E-7 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.090 1.91E-7 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.090 1.99E-7 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.090 2.05E-7 YOL134C_d YOL134C_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
0.089 2.46E-7 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.089 2.67E-7 YPR083W MDM36 hom Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission