HIPHOP chemogenomics database
YJL044C / GYP6 
GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJL044C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.115 | 2.31E-11 | YMR195W | ICY1 | hom | Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation |
| 0.110 | 1.92E-10 | YDR170C | SEC7 | het | Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles |
| 0.108 | 3.14E-10 | YLR297W | YLR297W | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication |
| 0.097 | 1.95E-8 | YLR401C | DUS3 | hom | Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress |
| 0.094 | 4.30E-8 | YER176W | ECM32 | hom | DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes |
| 0.094 | 5.07E-8 | YER145C | FTR1 | hom | High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress |
| 0.088 | 3.46E-7 | YOR185C | GSP2 | hom | GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress |
| 0.083 | 1.62E-6 | YDR269C_d | YDR269C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.082 | 1.97E-6 | YJR131W | MNS1 | hom | Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation |
| 0.081 | 2.51E-6 | YOR256C | TRE2 | het | Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication |
| 0.077 | 8.40E-6 | YOR007C | SGT2 | hom | Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress |
| 0.074 | 1.62E-5 | YGL104C | VPS73 | hom | Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family |
| 0.071 | 3.68E-5 | YAL064C-A_p | TDA8_p | hom | Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene |
| 0.071 | 4.10E-5 | YOL109W | ZEO1 | hom | Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria |
| 0.070 | 4.61E-5 | YPR128C | ANT1 | hom | Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation |