HIPHOP chemogenomics database
YJL051W / IRC8 
Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YJL051W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.190 | 1.61E-28 | YDR107C | TMN2 | hom | Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments |
| 0.188 | 4.10E-28 | YPR011C_p | YPR011C_p | hom | Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.167 | 2.17E-22 | YMR112C | MED11 | het | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein |
| 0.166 | 4.24E-22 | YBL001C | ECM15 | hom | Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis |
| 0.165 | 6.60E-22 | YDL086W_p | YDL086W_p | hom | Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene |
| 0.158 | 4.47E-20 | YGR022C_d | YGR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W |
| 0.156 | 1.11E-19 | YKR102W | FLO10 | hom | Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth |
| 0.152 | 9.64E-19 | YBL017C | PEP1 | hom | Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments |
| 0.147 | 9.60E-18 | YPR037C | ERV2 | hom | Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER |
| 0.144 | 4.35E-17 | YJL058C | BIT61 | hom | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication |
| 0.142 | 1.32E-16 | YBR067C | TIP1 | hom | Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins |
| 0.140 | 4.35E-16 | YLR154C | RNH203 | hom | Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome |
| 0.137 | 1.49E-15 | YBL070C_d | YBL070C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.129 | 6.08E-14 | YDR109C_p | YDR109C_p | hom | Putative kinase |
| 0.128 | 9.37E-14 | YLR349W_d | YLR349W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C |