HIPHOP chemogenomics database
YJL055W_p 
Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJL055W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.146 | 1.73E-17 | YDR392W | SPT3 | hom | Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters |
| 0.100 | 6.25E-9 | YKR003W | OSH6 | hom | Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion |
| 0.100 | 6.86E-9 | YKL096W | CWP1 | hom | Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance |
| 0.095 | 3.68E-8 | YOR001W | RRP6 | hom | Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay |
| 0.093 | 6.21E-8 | YML125C | PGA3 | het | Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication |
| 0.093 | 7.85E-8 | YKR028W | SAP190 | hom | Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication |
| 0.090 | 1.78E-7 | YJR006W | POL31 | het | Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair |
| 0.082 | 1.82E-6 | YKL046C | DCW1 | hom | Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p |
| 0.078 | 5.97E-6 | YLL056C_p | YLL056C_p | hom | Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin |
| 0.076 | 9.68E-6 | YNR003C | RPC34 | het | RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex |
| 0.075 | 1.31E-5 | YAL034W-A | MTW1 | het | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly |
| 0.072 | 2.66E-5 | YNR001C | CIT1 | hom | Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication |
| 0.072 | 2.85E-5 | YOL129W | VPS68 | hom | Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria |
| 0.071 | 4.36E-5 | YMR173W-A_d | YMR173W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W |
| 0.070 | 4.82E-5 | YPR052C | NHP6A | hom | High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |