YJL057C / IKS1

Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL057C / IKS1

Click on Significant Values for Screen Details ID:SGTC_743|Compound:1275-0778|FD-Score:-3.43|P-value:2.90E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.22|P-value:5.87E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.08|P-value:9.55E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.77|P-value:7.81E-7 ID:SGTC_1683|Compound:st010134|FD-Score:3.81|P-value:6.30E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:3.39|P-value:3.23E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.29|P-value:4.72E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.81|P-value:6.19E-5 ID:SGTC_1802|Compound:st050112|FD-Score:4.83|P-value:5.78E-7 ID:SGTC_1859|Compound:st055998|FD-Score:6.47|P-value:3.69E-11 ID:SGTC_1917|Compound:st066507|FD-Score:4.57|P-value:2.06E-6 ID:SGTC_2127|Compound:5253358|FD-Score:3.47|P-value:2.32E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.82|P-value:5.97E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.89|P-value:4.50E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.35|P-value:5.85E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.95|P-value:3.69E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.27|P-value:5.62E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.64|P-value:1.51E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.65|P-value:1.23E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.22|P-value:6.08E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.29|P-value:4.78E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.24|P-value:5.47E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.58|P-value:1.99E-6 ID:SGTC_3097|Compound:9117246|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_3319|Compound:9138450|FD-Score:4.26|P-value:8.81E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.43|P-value:2.90E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.22|P-value:5.87E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.08|P-value:9.55E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.77|P-value:7.81E-7 ID:SGTC_1683|Compound:st010134|FD-Score:3.81|P-value:6.30E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:3.39|P-value:3.23E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.29|P-value:4.72E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.81|P-value:6.19E-5 ID:SGTC_1802|Compound:st050112|FD-Score:4.83|P-value:5.78E-7 ID:SGTC_1859|Compound:st055998|FD-Score:6.47|P-value:3.69E-11 ID:SGTC_1917|Compound:st066507|FD-Score:4.57|P-value:2.06E-6 ID:SGTC_2127|Compound:5253358|FD-Score:3.47|P-value:2.32E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.82|P-value:5.97E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.89|P-value:4.50E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.35|P-value:5.85E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.95|P-value:3.69E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.27|P-value:5.62E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.64|P-value:1.51E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.65|P-value:1.23E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.22|P-value:6.08E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.29|P-value:4.78E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.24|P-value:5.47E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.58|P-value:1.99E-6 ID:SGTC_3097|Compound:9117246|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_3319|Compound:9138450|FD-Score:4.26|P-value:8.81E-6

Top fitness defect scores for YJL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1859 st055998 6.47 20.0 µM 3.69E-11 5 4.89E-11
2 SGTC_2636 apigenin dimethyl ether 5.27 100.0 µM 5.62E-8 15 6.82E-8
3 SGTC_1802 st050112 4.83 57.9 µM 5.78E-7 2 6.83E-7
4 SGTC_1673 st016611 4.77 27.3 µM 7.81E-7 25 9.18E-7
5 SGTC_2690 usnic acid 4.64 100.0 µM 1.51E-6 15 1.77E-6
6 SGTC_3020 9089140 4.58 49.5 µM 1.99E-6 15 2.31E-6
7 SGTC_1917 st066507 4.57 28.5 µM 2.06E-6 Golgi 28 2.40E-6
8 SGTC_2630 antimycin a 4.35 100.0 µM 5.85E-6 mitochondrial processes 28 6.71E-6
9 SGTC_3319 9138450 4.26 16.8 µM 8.81E-6 16 1.01E-5
10 SGTC_3097 9117246 4.18 49.5 µM 1.28E-5 7 1.46E-5
11 SGTC_2441 5730946 3.89 39.1 µM 4.50E-5 17 5.04E-5
12 SGTC_2418 pentamidine 3.82 31.7 µM 5.97E-5 mitochondrial processes 49 6.67E-5
13 SGTC_1759 st043059 3.81 70.0 µM 6.19E-5 amide catabolism 31 6.91E-5
14 SGTC_1683 st010134 3.81 710.0 nM 6.30E-5 36 7.03E-5
15 SGTC_2600 tangeritin 3.67 88.0 µM 1.11E-4 44 1.23E-4
16 SGTC_2127 5253358 3.47 187.9 µM 2.32E-4 38 2.55E-4
17 SGTC_1693 xanthone 3.39 101.9 µM 3.23E-4 DNA damage response 27 3.53E-4
18 SGTC_1407 3909-7909 3.34 12.3 µM 3.84E-4 60S ribosome export 29 4.20E-4
19 SGTC_2962 9082311 3.24 13.2 µM 5.47E-4 52 5.95E-4
20 SGTC_770 0389-1121 3.22 67.2 µM 5.87E-4 RPP1 & pyrimidine depletion 61 6.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.50E-15 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.112 8.55E-11 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.110 1.80E-10 YGR075C PRP38 het Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly
0.098 1.17E-8 YJL067W_d YJL067W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.97E-8 YJL100W LSB6 hom Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.095 3.90E-8 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.092 9.27E-8 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.088 3.42E-7 YDL085C-A_p YDL085C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.086 7.08E-7 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.085 8.21E-7 YAL067C SEO1 hom Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
0.082 2.22E-6 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.078 5.47E-6 YKL107W_p YKL107W_p hom Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein
0.078 6.61E-6 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.078 6.76E-6 YNR049C MSO1 hom Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress
0.078 6.90E-6 YOR351C MEK1 hom Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids