YJL061W / NUP82

Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL061W / NUP82

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:-3.53|P-value:1.46E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.09|P-value:7.06E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.40|P-value:3.05E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:3.74|P-value:5.67E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.58|P-value:1.20E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.07|P-value:8.10E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.06|P-value:1.35E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.75|P-value:5.41E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.37|P-value:2.51E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.09|P-value:7.54E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.10|P-value:6.68E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.03|P-value:8.57E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.52|P-value:1.52E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.07|P-value:7.59E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.11|P-value:6.50E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.08|P-value:7.15E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.28|P-value:3.50E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.56|P-value:1.29E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.21|P-value:4.59E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.96|P-value:2.17E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.12|P-value:6.32E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.14|P-value:5.88E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.45|P-value:2.02E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.07|P-value:7.58E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.35|P-value:2.62E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.33|P-value:3.19E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.47|P-value:1.85E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.54|P-value:1.27E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.66|P-value:7.66E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.00|P-value:1.24E-7 ID:SGTC_2132|Compound:5317594|FD-Score:-5.63|P-value:3.51E-9 ID:SGTC_2136|Compound:5328288|FD-Score:4.79|P-value:3.84E-7 ID:SGTC_2156|Compound:5649887|FD-Score:4.33|P-value:3.78E-6 ID:SGTC_2327|Compound:6189656|FD-Score:3.64|P-value:8.42E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-4.11|P-value:1.23E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.77|P-value:4.85E-5 ID:SGTC_2447|Compound:5741742|FD-Score:5.07|P-value:8.37E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:6.35|P-value:2.77E-11 ID:SGTC_2808|Compound:7946468|FD-Score:3.23|P-value:4.23E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.20|P-value:4.63E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.33|P-value:3.88E-6 ID:SGTC_3238|Compound:9133470|FD-Score:3.22|P-value:4.34E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.53|P-value:1.46E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.09|P-value:7.06E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.40|P-value:3.05E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:3.74|P-value:5.67E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.58|P-value:1.20E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.07|P-value:8.10E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.06|P-value:1.35E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.75|P-value:5.41E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.37|P-value:2.51E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.09|P-value:7.54E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.10|P-value:6.68E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.03|P-value:8.57E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.52|P-value:1.52E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.07|P-value:7.59E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.11|P-value:6.50E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.10|P-value:6.81E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.08|P-value:7.15E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.28|P-value:3.50E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.56|P-value:1.29E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.21|P-value:4.59E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.96|P-value:2.17E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.12|P-value:6.32E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.14|P-value:5.88E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.45|P-value:2.02E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.07|P-value:7.58E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.35|P-value:2.62E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.33|P-value:3.19E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.47|P-value:1.85E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.54|P-value:1.27E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.66|P-value:7.66E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.00|P-value:1.24E-7 ID:SGTC_2132|Compound:5317594|FD-Score:-5.63|P-value:3.51E-9 ID:SGTC_2136|Compound:5328288|FD-Score:4.79|P-value:3.84E-7 ID:SGTC_2156|Compound:5649887|FD-Score:4.33|P-value:3.78E-6 ID:SGTC_2327|Compound:6189656|FD-Score:3.64|P-value:8.42E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-4.11|P-value:1.23E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.77|P-value:4.85E-5 ID:SGTC_2447|Compound:5741742|FD-Score:5.07|P-value:8.37E-8 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:6.35|P-value:2.77E-11 ID:SGTC_2808|Compound:7946468|FD-Score:3.23|P-value:4.23E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.20|P-value:4.63E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.33|P-value:3.88E-6 ID:SGTC_3238|Compound:9133470|FD-Score:3.22|P-value:4.34E-4

Top fitness defect scores for YJL061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2598 perillyl alcohol 6.35 100.0 µM 2.77E-11 2 1.06E-10 1.11
2 SGTC_2447 5741742 5.07 33.8 µM 8.37E-8 4 2.01E-7 0.13
3 SGTC_2131 toluylene red 5.00 5.3 µM 1.24E-7 60S ribosome export 8 2.92E-7 0.06
4 SGTC_2136 5328288 4.79 199.3 µM 3.84E-7 6 8.46E-7 0.07
5 SGTC_926 2268-1401 4.52 59.4 µM 1.52E-6 TSC3-RPN4 5 3.08E-6 0.06
6 SGTC_2156 5649887 4.33 115.0 µM 3.78E-6 RPP1 & pyrimidine depletion 14 7.30E-6 0.08
7 SGTC_2926 9010726 4.33 65.2 µM 3.88E-6 3 7.49E-6 0.18
8 SGTC_673 1082-0474 4.06 110.0 µM 1.35E-5 RSC complex & mRNA processing 52 2.43E-5 0.12
9 SGTC_1177 0983-0204 3.96 23.6 µM 2.17E-5 7 3.79E-5 0.01
10 SGTC_2443 5493264 3.77 126.7 µM 4.85E-5 8 8.09E-5 0.04
11 SGTC_690 glyoxal 3.75 20.3 µM 5.41E-5 28 8.97E-5 0.02
12 SGTC_152 4469-0003 3.74 551.2 µM 5.67E-5 14 9.37E-5 0.03
13 SGTC_2126 5251174 3.66 33.9 µM 7.66E-5 10 1.24E-4 0.02
14 SGTC_2327 6189656 3.64 200.0 µM 8.42E-5 11 1.36E-4 0.01
15 SGTC_216 k038-0035 3.54 28.4 µM 1.26E-4 ubiquinone biosynthesis & proteasome 22 1.99E-4 0.13
16 SGTC_2017 5132927 3.54 60.6 µM 1.27E-4 9 2.00E-4 0.07
17 SGTC_2406 ethylparaben 3.41 405.7 µM 2.09E-4 11 3.21E-4 0.01
18 SGTC_734 2023-0417 3.37 80.0 µM 2.51E-4 ergosterol biosynthesis 16 3.81E-4 0.01
19 SGTC_1767 st044992 3.35 70.3 µM 2.62E-4 6 3.97E-4 0.03
20 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 3.28 15.5 µM 3.50E-4 5 5.21E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 3.84E-15 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.115 2.06E-11 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.112 9.34E-11 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.111 9.91E-11 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.111 1.21E-10 YNL191W DUG3 hom Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
0.108 2.95E-10 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.103 2.04E-9 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.099 8.07E-9 YER081W SER3 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication
0.099 1.02E-8 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.096 2.94E-8 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.095 3.71E-8 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.095 3.78E-8 YLR249W YEF3 het Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
0.093 6.08E-8 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.085 8.58E-7 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.084 9.77E-7 YLR368W MDM30 hom F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains