YJL062W-A / COA3

Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL062W-A / COA3

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:5.81|P-value:5.00E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:14.50|P-value:1.37E-52 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.41|P-value:1.69E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:20.90|P-value:4.65E-107 ID:SGTC_386|Compound:1509-0011|FD-Score:19.20|P-value:2.93E-91 ID:SGTC_543|Compound:3844-1095|FD-Score:5.15|P-value:3.21E-8 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.23|P-value:3.45E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.23|P-value:3.50E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.32|P-value:2.46E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.07|P-value:9.42E-6 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.09|P-value:5.82E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.61|P-value:7.41E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:-4.05|P-value:1.03E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.20|P-value:3.76E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.74|P-value:3.13E-7 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.48|P-value:1.30E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:2.96|P-value:9.50E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.21|P-value:3.67E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.10|P-value:5.55E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.05|P-value:6.82E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.05|P-value:6.76E-4 ID:SGTC_1635|Compound:st007035|FD-Score:13.30|P-value:1.46E-44 ID:SGTC_1851|Compound:st056236|FD-Score:4.85|P-value:1.69E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.11|P-value:5.39E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.10|P-value:5.65E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-3.35|P-value:2.15E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.37|P-value:2.00E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.41|P-value:1.67E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.46|P-value:1.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.24|P-value:3.30E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.99|P-value:1.37E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.58|P-value:8.31E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.61|P-value:7.47E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.97|P-value:8.61E-8 ID:SGTC_2551|Compound:apiole|FD-Score:3.62|P-value:7.27E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.37|P-value:1.99E-4 ID:SGTC_2849|Compound:9019321|FD-Score:9.38|P-value:3.35E-23 ID:SGTC_2934|Compound:9036370|FD-Score:3.40|P-value:1.79E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.07|P-value:6.22E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.59|P-value:7.99E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.22|P-value:3.58E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.51|P-value:1.11E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.30|P-value:2.67E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.41|P-value:1.68E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.81|P-value:5.00E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:14.50|P-value:1.37E-52 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.41|P-value:1.69E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:20.90|P-value:4.65E-107 ID:SGTC_386|Compound:1509-0011|FD-Score:19.20|P-value:2.93E-91 ID:SGTC_543|Compound:3844-1095|FD-Score:5.15|P-value:3.21E-8 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.23|P-value:3.45E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.23|P-value:3.50E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.32|P-value:2.46E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.07|P-value:9.42E-6 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.09|P-value:5.82E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.61|P-value:7.41E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:-4.05|P-value:1.03E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.20|P-value:3.76E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.74|P-value:3.13E-7 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.48|P-value:1.30E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:2.96|P-value:9.50E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.21|P-value:3.67E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.10|P-value:5.55E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.05|P-value:6.82E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.05|P-value:6.76E-4 ID:SGTC_1635|Compound:st007035|FD-Score:13.30|P-value:1.46E-44 ID:SGTC_1851|Compound:st056236|FD-Score:4.85|P-value:1.69E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.11|P-value:5.39E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.10|P-value:5.65E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-3.35|P-value:2.15E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.37|P-value:2.00E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.41|P-value:1.67E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.46|P-value:1.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.24|P-value:3.30E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.99|P-value:1.37E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.58|P-value:8.31E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.61|P-value:7.47E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.97|P-value:8.61E-8 ID:SGTC_2551|Compound:apiole|FD-Score:3.62|P-value:7.27E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.37|P-value:1.99E-4 ID:SGTC_2849|Compound:9019321|FD-Score:9.38|P-value:3.35E-23 ID:SGTC_2934|Compound:9036370|FD-Score:3.40|P-value:1.79E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.07|P-value:6.22E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.59|P-value:7.99E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.22|P-value:3.58E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.51|P-value:1.11E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.30|P-value:2.67E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.41|P-value:1.68E-4

Top fitness defect scores for YJL062W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 20.90 5.3 µM 4.65E-107 47 3.91E-97
2 SGTC_386 1509-0011 19.20 3.1 µM 2.93E-91 9 7.89E-83
3 SGTC_134 0269-0018 14.50 6.9 µM 1.37E-52 21 8.24E-48
4 SGTC_1635 st007035 13.30 42.4 µM 1.46E-44 50 1.54E-40
5 SGTC_2849 9019321 9.38 13.0 µM 3.35E-23 1 3.45E-21
6 SGTC_87 0100-0052 5.81 35.5 µM 5.00E-10 36 3.05E-9
7 SGTC_543 3844-1095 5.15 191.0 µM 3.21E-8 ERG2 23 1.33E-7
8 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.97 100.0 µM 8.61E-8 3 3.27E-7
9 SGTC_1851 st056236 4.85 18.9 µM 1.69E-7 4 6.03E-7
10 SGTC_799 1310-0557 4.07 151.0 µM 9.42E-6 superoxide 18 2.33E-5
11 SGTC_2316 5844804 3.99 197.4 µM 1.37E-5 29 3.28E-5
12 SGTC_2551 apiole 3.62 73.9 µM 7.27E-5 13 1.50E-4
13 SGTC_2537 larixol 3.61 68.9 µM 7.47E-5 33 1.53E-4
14 SGTC_3124 9127567 3.59 49.5 µM 7.99E-5 DNA damage response 23 1.63E-4
15 SGTC_2328 6201408 3.58 200.0 µM 8.31E-5 30 1.69E-4
16 SGTC_3257 9139206 3.51 33.0 µM 1.11E-4 10 2.20E-4
17 SGTC_3065 9113888 3.49 49.5 µM 1.22E-4 37 2.39E-4
18 SGTC_1157 4092-0394 3.48 27.6 µM 1.30E-4 41 2.55E-4
19 SGTC_2190 6049624 3.46 200.0 µM 1.39E-4 10 2.71E-4
20 SGTC_2150 5556613 3.41 200.0 µM 1.67E-4 30 3.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.712 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.711 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.700 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.694 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.674 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.666 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.666 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.664 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.655 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.653 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.647 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.646 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.641 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.633 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.631 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes