YJL088W / ARG3

Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL088W / ARG3

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:5.91|P-value:7.11E-9 ID:SGTC_8|Compound:0354-0001|FD-Score:3.91|P-value:8.80E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.87|P-value:1.46E-6 ID:SGTC_13|Compound:0199-0087|FD-Score:3.62|P-value:2.59E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.28|P-value:2.00E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:14.30|P-value:2.67E-43 ID:SGTC_85|Compound:0868-0259|FD-Score:4.52|P-value:7.36E-6 ID:SGTC_101|Compound:0490-5701|FD-Score:3.49|P-value:4.16E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:4.31|P-value:1.76E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:6.11|P-value:2.17E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:5.57|P-value:4.35E-8 ID:SGTC_180|Compound:1486-1293|FD-Score:8.05|P-value:5.04E-15 ID:SGTC_205|Compound:1486-1330|FD-Score:6.92|P-value:1.45E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:4.00|P-value:6.34E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:5.47|P-value:7.59E-8 ID:SGTC_305|Compound:1682-2595|FD-Score:4.19|P-value:2.89E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:5.22|P-value:2.66E-7 ID:SGTC_349|Compound:k015-0014|FD-Score:5.81|P-value:1.22E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:3.42|P-value:5.20E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:2.91E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.86|P-value:9.34E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.27|P-value:2.09E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.47|P-value:4.46E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.89|P-value:9.57E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.79|P-value:2.13E-6 ID:SGTC_786|Compound:4544-0069|FD-Score:4.00|P-value:6.22E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:5.77|P-value:1.54E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:6.26|P-value:8.97E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:5.27|P-value:2.09E-7 ID:SGTC_826|Compound:1683-5028|FD-Score:3.23|P-value:9.98E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.99|P-value:6.64E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.30|P-value:7.93E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.37|P-value:6.18E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:8.06|P-value:4.91E-15 ID:SGTC_1081|Compound:sertraline|FD-Score:4.39|P-value:1.25E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:3.89|P-value:9.43E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.55|P-value:3.30E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.61|P-value:2.68E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:5.01|P-value:7.74E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.06|P-value:3.03E-9 ID:SGTC_1197|Compound:1601-0112|FD-Score:-5.33|P-value:1.27E-7 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.10|P-value:4.23E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.28|P-value:8.50E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.25|P-value:1.97E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.84|P-value:1.16E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.50|P-value:6.56E-8 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.90|P-value:1.65E-11 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.29|P-value:8.13E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.31|P-value:7.54E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.48|P-value:8.49E-6 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.12|P-value:4.42E-7 ID:SGTC_1673|Compound:st016611|FD-Score:10.40|P-value:7.17E-24 ID:SGTC_1699|Compound:st031318|FD-Score:3.52|P-value:3.68E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.32|P-value:7.46E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.12|P-value:3.96E-5 ID:SGTC_1717|Compound:st033143|FD-Score:4.57|P-value:5.76E-6 ID:SGTC_1750|Compound:st081859|FD-Score:7.87|P-value:1.92E-14 ID:SGTC_1778|Compound:st046819|FD-Score:4.52|P-value:7.17E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.78|P-value:1.46E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.57|P-value:5.72E-6 ID:SGTC_1837|Compound:st055472|FD-Score:5.14|P-value:4.10E-7 ID:SGTC_1893|Compound:st059353|FD-Score:-3.67|P-value:1.88E-4 ID:SGTC_1907|Compound:st060210|FD-Score:5.49|P-value:6.75E-8 ID:SGTC_1934|Compound:st074720|FD-Score:4.93|P-value:1.10E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.45|P-value:4.66E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.92|P-value:8.68E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.51|P-value:3.86E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.93|P-value:8.35E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.22|P-value:2.60E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.46|P-value:4.53E-4 ID:SGTC_2137|Compound:5261020|FD-Score:7.32|P-value:1.02E-12 ID:SGTC_2254|Compound:7938975|FD-Score:5.54|P-value:5.22E-8 ID:SGTC_2319|Compound:6033012|FD-Score:-4.68|P-value:3.00E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.36|P-value:6.46E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-4.97|P-value:7.66E-7 ID:SGTC_2324|Compound:6149169|FD-Score:3.27|P-value:8.61E-4 ID:SGTC_2332|Compound:7982454|FD-Score:6.00|P-value:4.22E-9 ID:SGTC_2444|Compound:5485484|FD-Score:5.95|P-value:5.45E-9 ID:SGTC_2463|Compound:5473429|FD-Score:4.43|P-value:1.06E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.25|P-value:9.35E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.26|P-value:8.84E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.98|P-value:6.66E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.51|P-value:7.70E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.49|P-value:4.07E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.89|P-value:9.68E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.43|P-value:5.08E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.72|P-value:2.95E-6 ID:SGTC_3149|Compound:9097855|FD-Score:3.44|P-value:4.96E-4 ID:SGTC_3211|Compound:9128781|FD-Score:10.40|P-value:5.93E-24 ID:SGTC_5|Compound:0352-0601|FD-Score:5.91|P-value:7.11E-9 ID:SGTC_8|Compound:0354-0001|FD-Score:3.91|P-value:8.80E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.87|P-value:1.46E-6 ID:SGTC_13|Compound:0199-0087|FD-Score:3.62|P-value:2.59E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.28|P-value:2.00E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:14.30|P-value:2.67E-43 ID:SGTC_85|Compound:0868-0259|FD-Score:4.52|P-value:7.36E-6 ID:SGTC_101|Compound:0490-5701|FD-Score:3.49|P-value:4.16E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:4.31|P-value:1.76E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:6.11|P-value:2.17E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:5.57|P-value:4.35E-8 ID:SGTC_180|Compound:1486-1293|FD-Score:8.05|P-value:5.04E-15 ID:SGTC_205|Compound:1486-1330|FD-Score:6.92|P-value:1.45E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:4.00|P-value:6.34E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:5.47|P-value:7.59E-8 ID:SGTC_305|Compound:1682-2595|FD-Score:4.19|P-value:2.89E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:5.22|P-value:2.66E-7 ID:SGTC_349|Compound:k015-0014|FD-Score:5.81|P-value:1.22E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:3.42|P-value:5.20E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:2.91E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.86|P-value:9.34E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.27|P-value:2.09E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.47|P-value:4.46E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.89|P-value:9.57E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.79|P-value:2.13E-6 ID:SGTC_786|Compound:4544-0069|FD-Score:4.00|P-value:6.22E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:5.77|P-value:1.54E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:6.26|P-value:8.97E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:5.27|P-value:2.09E-7 ID:SGTC_826|Compound:1683-5028|FD-Score:3.23|P-value:9.98E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.99|P-value:6.64E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:3.30|P-value:7.93E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.37|P-value:6.18E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:8.06|P-value:4.91E-15 ID:SGTC_1081|Compound:sertraline|FD-Score:4.39|P-value:1.25E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:3.89|P-value:9.43E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.55|P-value:3.30E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.61|P-value:2.68E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:5.01|P-value:7.74E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.06|P-value:3.03E-9 ID:SGTC_1197|Compound:1601-0112|FD-Score:-5.33|P-value:1.27E-7 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.10|P-value:4.23E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.28|P-value:8.50E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.25|P-value:1.97E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.84|P-value:1.16E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.50|P-value:6.56E-8 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.90|P-value:1.65E-11 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.29|P-value:8.13E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.31|P-value:7.54E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.48|P-value:8.49E-6 ID:SGTC_1445|Compound:4239-0156|FD-Score:5.12|P-value:4.42E-7 ID:SGTC_1673|Compound:st016611|FD-Score:10.40|P-value:7.17E-24 ID:SGTC_1699|Compound:st031318|FD-Score:3.52|P-value:3.68E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.32|P-value:7.46E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.12|P-value:3.96E-5 ID:SGTC_1717|Compound:st033143|FD-Score:4.57|P-value:5.76E-6 ID:SGTC_1750|Compound:st081859|FD-Score:7.87|P-value:1.92E-14 ID:SGTC_1778|Compound:st046819|FD-Score:4.52|P-value:7.17E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.78|P-value:1.46E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.57|P-value:5.72E-6 ID:SGTC_1837|Compound:st055472|FD-Score:5.14|P-value:4.10E-7 ID:SGTC_1893|Compound:st059353|FD-Score:-3.67|P-value:1.88E-4 ID:SGTC_1907|Compound:st060210|FD-Score:5.49|P-value:6.75E-8 ID:SGTC_1934|Compound:st074720|FD-Score:4.93|P-value:1.10E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.45|P-value:4.66E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.92|P-value:8.68E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.51|P-value:3.86E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.93|P-value:8.35E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.22|P-value:2.60E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.46|P-value:4.53E-4 ID:SGTC_2137|Compound:5261020|FD-Score:7.32|P-value:1.02E-12 ID:SGTC_2254|Compound:7938975|FD-Score:5.54|P-value:5.22E-8 ID:SGTC_2319|Compound:6033012|FD-Score:-4.68|P-value:3.00E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.36|P-value:6.46E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-4.97|P-value:7.66E-7 ID:SGTC_2324|Compound:6149169|FD-Score:3.27|P-value:8.61E-4 ID:SGTC_2332|Compound:7982454|FD-Score:6.00|P-value:4.22E-9 ID:SGTC_2444|Compound:5485484|FD-Score:5.95|P-value:5.45E-9 ID:SGTC_2463|Compound:5473429|FD-Score:4.43|P-value:1.06E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.25|P-value:9.35E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.26|P-value:8.84E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.98|P-value:6.66E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.51|P-value:7.70E-6 ID:SGTC_2924|Compound:9010168|FD-Score:3.49|P-value:4.07E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.89|P-value:9.68E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.43|P-value:5.08E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.72|P-value:2.95E-6 ID:SGTC_3149|Compound:9097855|FD-Score:3.44|P-value:4.96E-4 ID:SGTC_3211|Compound:9128781|FD-Score:10.40|P-value:5.93E-24

Top fitness defect scores for YJL088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_54 0159-0055 14.30 9.0 µM 2.67E-43 ERG2 5 1.28E-46
2 SGTC_3211 9128781 10.40 49.5 µM 5.93E-24 5 9.50E-26
3 SGTC_1673 st016611 10.40 27.3 µM 7.17E-24 6 1.17E-25
4 SGTC_1011 4112-3381 8.06 17.4 µM 4.91E-15 7 3.97E-16
5 SGTC_180 1486-1293 8.05 102.8 µM 5.04E-15 15 4.09E-16
6 SGTC_1750 st081859 7.87 2.4 µM 1.92E-14 endomembrane recycling 70 1.73E-15
7 SGTC_2137 5261020 7.32 140.0 µM 1.02E-12 8 1.26E-13
8 SGTC_205 1486-1330 6.92 71.9 µM 1.45E-11 4 2.20E-12
9 SGTC_1304 1165-0502 6.90 251.0 µM 1.65E-11 22 2.54E-12
10 SGTC_811 0416-0114 6.26 265.0 µM 8.97E-10 2 1.89E-10
11 SGTC_161 4065-0411 6.11 162.2 µM 2.17E-9 26 4.91E-10
12 SGTC_1194 1488-0194 6.06 225.0 µM 3.03E-9 5 7.01E-10
13 SGTC_2332 7982454 6.00 138.9 µM 4.22E-9 17 1.00E-9
14 SGTC_2444 5485484 5.95 36.4 µM 5.45E-9 8 1.32E-9
15 SGTC_5 0352-0601 5.91 109.9 µM 7.11E-9 ERG2 3 1.76E-9
16 SGTC_349 k015-0014 5.81 24.0 µM 1.22E-8 3 3.15E-9
17 SGTC_793 0488-0545 5.77 106.0 µM 1.54E-8 4 4.05E-9
18 SGTC_176 1486-1328 5.57 72.8 µM 4.35E-8 26 1.24E-8
19 SGTC_2254 7938975 5.54 95.2 µM 5.22E-8 24 1.51E-8
20 SGTC_1263 0774-1208 5.50 64.8 µM 6.56E-8 13 1.93E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.303 3.76E-72 YOL058W ARG1 hom Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.287 1.21E-64 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.233 1.20E-42 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.226 4.76E-40 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.197 1.59E-30 YOR130C ORT1 hom Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
0.191 9.24E-29 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.169 9.77E-23 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.162 3.78E-21 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.160 9.76E-21 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.154 3.41E-19 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.145 3.88E-17 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.141 1.77E-16 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.141 2.39E-16 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.138 8.83E-16 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.130 4.14E-14 YJR109C CPA2 hom Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor