HIPHOP chemogenomics database
YJL090C / DPB11 
DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YJL090C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.121 | 1.61E-12 | YJL102W | MEF2 | hom | Mitochondrial elongation factor involved in translational elongation |
| 0.109 | 2.47E-10 | YIL078W | THS1 | het | Threonyl-tRNA synthetase, essential cytoplasmic protein |
| 0.106 | 8.48E-10 | YPR033C | HTS1 | het | Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome |
| 0.104 | 1.58E-9 | YML065W | ORC1 | het | Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity |
| 0.098 | 1.23E-8 | YOR277C_d | YOR277C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 |
| 0.095 | 3.70E-8 | YNL271C | BNI1 | hom | Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 |
| 0.089 | 2.68E-7 | YNL188W | KAR1 | het | Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p |
| 0.086 | 5.63E-7 | YLL011W | SOF1 | het | Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p |
| 0.084 | 1.23E-6 | YER048W-A | ISD11 | het | Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis |
| 0.082 | 1.81E-6 | YGR172C | YIP1 | het | Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 |
| 0.082 | 2.09E-6 | YGR245C | SDA1 | het | Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis |
| 0.082 | 2.41E-6 | YMR088C | VBA1 | hom | Permease of basic amino acids in the vacuolar membrane |
| 0.078 | 5.70E-6 | YOL096C | COQ3 | hom | O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein |
| 0.078 | 6.47E-6 | YGL074C_d | YGL074C_d | het | Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor |
| 0.077 | 8.49E-6 | YML046W | PRP39 | het | U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats |