HIPHOP chemogenomics database
YJL093C / TOK1 
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YJL093C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.127 | 1.36E-13 | YPR054W | SMK1 | hom | Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p |
| 0.106 | 9.09E-10 | YPR058W | YMC1 | hom | Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication |
| 0.100 | 6.06E-9 | YHR146W | CRP1 | hom | Protein that binds to cruciform DNA structures |
| 0.099 | 7.96E-9 | YGR242W_d | YGR242W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C |
| 0.097 | 1.85E-8 | YKL027W | YKL027W | hom | Protein of unknown function, localized to the mitochondrial outer membrane |
| 0.095 | 4.11E-8 | YNL120C_d | YNL120C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene |
| 0.094 | 4.16E-8 | YLR050C_p | YLR050C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene |
| 0.092 | 9.73E-8 | YPL182C_d | YPL182C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W |
| 0.087 | 4.24E-7 | YOR264W | DSE3 | hom | Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.086 | 5.63E-7 | YGR266W | YGR266W | hom | Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress |
| 0.085 | 7.34E-7 | YDR459C | PFA5 | hom | Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain |
| 0.083 | 1.60E-6 | YOR105W_p | YOR105W_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
| 0.083 | 1.66E-6 | YLR080W | EMP46 | hom | Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport |
| 0.081 | 2.92E-6 | YNL009W | IDP3 | hom | Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication |
| 0.081 | 2.94E-6 | YJR002W | MPP10 | het | Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p |